Novi vs SynergyRx: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher & Publisher

Reviewed & updated September 3, 2026 · Cites primary sources (FDA, NEJM, CMS) · Not medical advice

54 providers verified independently·Independent research·How we rank →

Short answer: Novi scores higher on our rubric, 7.8/10 against 7.6/10. Full reasoning, pricing and the cases where the other one wins are below.

Visit SynergyRx - from $199/mo →or find your match

Novi beats SynergyRx overall, scoring 7.8/10 vs 7.6/10. Published pricing is not a like-for-like monthly comparison: Novi is from $88/mo; SynergyRx is from $199/mo. Choose Novi for cash-pay patients who want compounded semaglutide or tirzepatide at a low monthly rate and can accept a three-month commitment charged upfront. Choose SynergyRx for needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included.

A side-by-side look at Novi and SynergyRx to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Higher Rated

Novi

#8 of 54

7.8/10

Telehealth platform for compounded semaglutide and tirzepatide that also lists brand-name Mounjaro, Ozempic, Wegovy and Zepbound in stock from $1500. Pricing is published per billing cycle on the product pages: compounded semaglutide at $149 for one month, $130 for three, $129 for six and $88 for twelve; compounded tirzepatide at $179, $149, $133 and $129 across the same cycles. The monthly price covers the consultation, medication, supplies, shipping and unlimited physician messaging, and it does not change with the dose. The homepage advertises "Cancel anytime", but the terms of service require a minimum three-month commitment charged upfront and called non-refundable.

Visit Novi

SynergyRx

#15 of 54

7.6/10

Bundled GLP-1 program covering the consult, medication and shipping in one monthly price, with round-the-clock support and needle-free tablet options.

Visit SynergyRx

Feature	Novi	SynergyRx
Why each one	One of the cheapest published compounded rates in the category, $88/mo for semaglutide and $129/mo for tirzepatide on a twelve-month cycle, on a site that also stocks brand-name Mounjaro, Ozempic, Wegovy and Zepbound from $1500. The price is real. So is the three-month commitment charged upfront that the homepage does not mention.	Oral dissolving tablets for BOTH semaglutide AND tirzepatide, serving needle-phobic patients who want injectable-level results without injections.
Our Score	7.8/10	7.6/10
Headline Price	from $88/mo	from $199/mo
Medication Type	Both	Both
Insurance Accepted	No	No
Best For	Cash-pay patients who want compounded semaglutide or tirzepatide at a low monthly rate and can accept a three-month commitment charged upfront	Needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included
Watch out for	The homepage advertises "Cancel anytime" and "No monthly membership", but the terms of service require a minimum three-month commitment with all three months charged at purchase and called non-refundable	The Casper, WY address in its terms is a suite mailbox rather than a clinic, and the brand has no Trustpilot profile, so there is little independent feedback to weigh against its own testimonials.
Ranking	#8	#15
Get started	Visit Novi	Visit SynergyRx

Pros & Cons Compared

Novi

Pros

+Compounded and brand-name GLP-1s in one catalogue: compounded semaglutide and tirzepatide with published rates, plus Mounjaro, Ozempic, Wegovy and Zepbound listed in stock from $1500
+Serves all 50 states and Washington DC, with a short video or audio visit required only in Kansas, Louisiana, Mississippi, New Mexico and West Virginia
+Per cycle prices are printed on the product pages instead of hidden behind the quiz: compounded semaglutide at $149 for one month, $130 for three, $129 for six and $88 for twelve
+Unlimited physician messaging, follow-ups and dose adjustments through the online portal, with consultation, supplies and shipping included in the monthly price and the same price at every dose
+Free 2-day shipping; Novi markets compounded semaglutide and tirzepatide, which are not FDA-approved brands or generics and are not established as equivalent to Wegovy, Ozempic, Mounjaro, or Zepbound
+On-time refills shipped every 28 days after a short check-in, with free discreet delivery quoted at two to three business days on the product pages

Cons

−The homepage advertises "Cancel anytime" and "No monthly membership", but the terms of service require a minimum three-month commitment with all three months charged at purchase and called non-refundable
−The only address Novi shows is a Sheridan, Wyoming mailing suite used by large numbers of registered LLCs, the terms name Novi International LLC in one place and Novi Health LLC in the arbitration clause, and no founding year is shown on its terms, privacy or FAQ pages (rendered check 2026-09-03)
−The cheapest advertised rates need the longest billing cycle: compounded semaglutide is $88/mo on the twelve-month cycle but $149/mo on the one-month cycle, and compounded tirzepatide runs $129/mo to $179/mo the same way
−The refund policy says Novi is "unable to accept returns", while the product pages advertise a Progress Promise full refund and point to the terms of service for the details; "Progress Promise" is not shown anywhere on that terms page (rendered check 2026-09-03)
−Lab requirements before prescribing are not disclosed on public pages, unclear whether baseline bloodwork is required
−The headline price on the homepage changes with screen width, $133/mo on a desktop and $99/mo on a phone at the same address, and it sits beside a countdown that restarts on every page load

SynergyRx

Pros

+Oral dissolving tablets for BOTH semaglutide AND tirzepatide, one of the few platforms with needle-free tirzepatide
+Free expedited shipping included with all orders
+24/7 support with unlimited messaging, no per-visit fees for follow-up questions or dose adjustments
+Both compounded and brand-name options available (Ozempic, Wegovy, Mounjaro)

Cons

−The Casper, WY address in its terms is a suite mailbox rather than a clinic, and the brand has no Trustpilot profile, so there is little independent feedback to weigh against its own testimonials.
−Brand-name pricing ($499-947/mo) is very high compared to direct manufacturer programs like LillyDirect. Use SynergyRx for its compounded oral tablets; source brand-name directly if that's what you need.
−Founding date and ownership are not shown on the site's contact, about, terms or FAQ pages (rendered check 2026-09-03); the terms disclose only a Delaware corporation. The terms also name Usable Health, PC as the medical group while the FAQ names Lion MD.

Our Verdict

Novi edges out SynergyRx with a score of 7.8/10 vs 7.6/10. Published pricing is not a like-for-like monthly comparison: Novi is from $88/mo; SynergyRx is from $199/mo.