Oak Longevity vs Yucca Health: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

53 providers verified independently·Independent research·How we rank →

Visit Yucca Health - our pick of these two→or find your match

Yucca Health beats Oak Longevity overall, scoring 7.7/10 vs 7.5/10. Oak Longevity is more affordable at $133/mo vs $146/mo. Choose Oak Longevity for budget-conscious users who want one of the cheapest compound. Choose Yucca Health for people who'll commit to a 6-month plan for $146/mo, want nam.

A side-by-side look at Oak Longevity and Yucca Health to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Oak Longevity

#25 of 53

7.5/10

Telehealth platform offering compounded semaglutide and tirzepatide at the lower end of market pricing, alongside an oral Wegovy option, brand-name FDA-approved GLP-1s, and a longevity stack (NAD+, Glutathione, Sermorelin, Tesamorelin). Distinctive non-subscription billing, patients pay each month manually rather than auto-renew.

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Higher Rated

Yucca Health

#17 of 53

7.7/10

Online weight-loss program by Yucca Health, Inc. (Beverly Hills, CA). Two named board-certified doctors, Dr. Michael Wasef MD and Dr. Andrew Sakla DO, handle prescribing. 20,000+ patients, 4.6 stars across 1,065 verified Trustpilot reviews. Starts at $146/mo for compounded semaglutide (custom-made version, not the FDA-approved brand) on the 6-month plan. Buy-now-pay-later via Klarna, Affirm, or Afterpay spreads the upfront commitment.

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Feature	Oak Longevity	Yucca Health
Our Score	7.5/10	7.7/10
Starting Price	$133/mo	$146/mo
Medication Type	Both	Compounded
Insurance Accepted	No	No
Best For	Budget-conscious users who want one of the cheapest compounded GLP-1 entries plus a no-subscription billing model and a longevity-stack add-on (NAD+, Sermorelin)	People who'll commit to a 6-month plan for $146/mo, want named doctors on record, and like buy-now-pay-later flexibility (Klarna/Affirm/Afterpay)
Watch out for	Brand-name pricing ($1,200-$1,500/mo) is significantly above market, NovoCare sells Wegovy direct at $349/mo and LillyDirect has Zepbound at $299/mo. Use Oak for its compounded tiers and buy brand-name direct	Compounded-only, no FDA-approved Wegovy, Zepbound, Ozempic, or Mounjaro.
Ranking	#25	#17
Get started	Visit Oak Longevity	Visit Yucca Health

Pros & Cons Compared

Oak Longevity

Pros

+$133/mo for compounded semaglutide is among the cheapest entries on the market, Sesame Care ($99) is lower, but Oak undercuts most mid-tier platforms
+No-subscription model, patients are not auto-charged each month, choose to renew manually. Reduces unwanted recurring charges
+Compounded tirzepatide at $199/mo is competitively priced for a GLP-1+GIP dual agonist
+Broadest medication mix on the platform: compounded sema + tirz, oral Wegovy, brand Wegovy/Ozempic/Zepbound/Mounjaro, plus longevity peptides (NAD+, Glutathione, Sermorelin, Tesamorelin)
+Money-back guarantee if not approved by physician, useful safety net for borderline-eligibility patients
+Free shipping and free health coaching included in every program

Cons

−Brand-name pricing ($1,200-$1,500/mo) is significantly above market, NovoCare sells Wegovy direct at $349/mo and LillyDirect has Zepbound at $299/mo. Use Oak for its compounded tiers and buy brand-name direct
−No published lab panels and no specialty (obesity medicine) physicians disclosed, clinical oversight is lighter than lab-driven platforms
−The 'up to 50% cheaper than competitors' marketing claim is unverified and inconsistent, judge Oak on its posted prices, which are genuinely low, not on the slogan
−The longevity add-ons (NAD+, Sermorelin, Tesamorelin) have limited clinical evidence for weight loss specifically, if weight loss is the goal, the GLP-1 alone does the work and the stack is optional
−Newer brand without disclosed company history, founding date, or executive team on landing pages
−Three-month plans are billed upfront, start on the 1-month plan if you're testing the platform, then bundle once it fits

Yucca Health

Pros

+Two named board-certified doctors (Dr. Michael Wasef MD and Dr. Andrew Sakla DO), most compounded GLP-1 providers don't publicly name their prescribers.
+4.6 stars across 1,065 verified Trustpilot reviews, 84% give 5 stars. Top complimented theme: customer service.
+Cheap if you commit: $146/mo for compounded semaglutide on the 6-month plan.
+Buy-now-pay-later through Klarna, Affirm, and Afterpay, unusual flexibility in this category, useful for spreading the 6-month upfront cost.
+24-hour async approval, no live video visit required. Faster onboarding than competitors that need a scheduled call.
+UPS 2-Day Air shipping included. Onboarding call from a real human (multiple Trustpilot reviewers name 'Hazel' and 'Johann' from the team).
+Replies to 100% of negative Trustpilot reviews, usually within 48 hours.

Cons

−Compounded-only, no FDA-approved Wegovy, Zepbound, Ozempic, or Mounjaro.
−The $146/mo price requires a 6-month upfront commitment (month-to-month is meaningfully more expensive). The Klarna/Affirm/Afterpay financing exists to spread exactly that upfront cost.
−No live tele-visit option, only async review. Faster, but less depth if you have a complex health history and want a provider you can talk to.
−Pharmacy partner not named publicly. Yucca says 'U.S. licensed pharmacies' but doesn't disclose which one.
−Founders and detailed company history not on the site.
−Refund policy is mentioned but not detailed publicly, get the cancellation terms in writing before paying for the 6-month plan.

Our Verdict

Yucca Health edges out Oak Longevity with a score of 7.7/10 vs 7.5/10. If budget is your priority, Oak Longevity starts at $133/mo compared to Yucca Health's $146/mo. Oak Longevity offers both brand-name and compounded medications, giving you more flexibility. Choose Oak Longevity if you want: budget-conscious users who want one of the cheapest compounded glp-1 entries plus a no-subscription billing model and a longevity-stack add-on (nad+, sermorelin). Choose Yucca Health if you want: people who'll commit to a 6-month plan for $146/mo, want named doctors on record, and like buy-now-pay-later flexibility (klarna/affirm/afterpay).

Still undecided? Editor's Featured Pick

TrimRx

$149/mo · 7.8/10 · Compounded

If neither Oak Longevity nor Yucca Health feels like the right fit, our featured pick across all 53 GLP-1 telehealth providers is TrimRx. It is not the highest-scored provider in our full rankings. We feature it for its low-friction value: a flat $149/mo that stays the same at every dose.

Visit TrimRx→Read our full TrimRx review