Calibrate vs Yucca Health: Which GLP-1 Provider Is Better?
By Iacob Pastina, Independent Researcher
Calibrate and Yucca Health are tied at 7.7/10. Yucca Health is more affordable at $146/mo vs $199/mo. Choose Calibrate for users who want a physician-led metabolic health program with. Choose Yucca Health for cash-pay patients who want a quick 24-hour async approval fo.
A side-by-side comparison of Calibrate and Yucca Health covering pricing, scores, medication types, insurance, and more to help you decide.
Calibrate
#21 of 46Metabolic health company offering a physician-led GLP-1 program restructured in 2026: $199/mo with a 3-month minimum commitment (no more $1,649 one-time enrollment fee). Includes nutrition coaching, labs, a smart scale, and a 10%+ weight-loss guarantee with 50% money-back.
Visit CalibrateYucca Health
#19 of 46Telehealth platform for compounded semaglutide+ and tirzepatide+ with disclosed board-certified prescribers (Dr. Michael Wasef MD and Dr. Andrew Sakla DO), 24-hour asynchronous provider review, UPS 2-Day Air shipping, and integrated buy-now-pay-later financing through Klarna, Affirm, and Afterpay. Pricing is plan-length-tiered: 6-month plan starts at $146/mo for compounded semaglutide and $258/mo for compounded tirzepatide, with monthly pricing higher.
Visit Yucca Health| Feature | Calibrate | Yucca Health |
|---|---|---|
| Our Score | 7.7/10 | 7.7/10 |
| Starting Price | $199/mo | $146/mo |
| Medication Type | Both | Compounded |
| Insurance Accepted | Yes | No |
| Best For | Users who want a physician-led metabolic health program with a 3-month commitment and a weight-loss guarantee | Cash-pay patients who want a quick 24-hour async approval for compounded semaglutide or tirzepatide with disclosed prescribing physicians, UPS 2-Day shipping, and Klarna/Affirm/Afterpay buy-now-pay-later options on longer commitments |
| Ranking | #21 | #19 |
Pros & Cons Compared
Calibrate
Pros
- +2026 pricing rewrite — flat $199/mo with 3-month commitment ($597 upfront), then month-to-month. The old $1,649 one-time enrollment fee was removed.
- +Board-certified physicians with metabolic health specialization lead treatment
- +10%+ body-weight-loss guarantee with 50% money-back if not met
- +Includes labs, nutrition coaching, personalized smart scale, and sleep/exercise support
Cons
- −$597 upfront (3-month commitment) is a meaningful barrier vs. month-to-month competitors
- −Medication cost is separate and varies significantly by payer route
- −Fewer medications in the menu than marketplaces like Sesame Care or Ro
- −Onboarding still takes 2-3 weeks to complete baseline labs and treatment plan
Yucca Health
Pros
- +Two named board-certified prescribers publicly disclosed (Dr. Michael Wasef MD and Dr. Andrew Sakla DO) — rare for the compounded-only tier
- +$146/mo entry price for compounded semaglutide on the 6-month plan is competitive with GobyMeds, Strut, and Mochi at the cheaper end of the market
- +Klarna, Affirm, and Afterpay buy-now-pay-later financing on the 6-month commitments — unique among compounded-only telehealth and useful for spreading the upfront cost
- +24-hour asynchronous provider approval (no live tele-visit required) for users who want fast onboarding without scheduling friction
- +UPS 2-Day Air shipping with secure patient portal, 24/7 support team availability, and welcome onboarding call with a representative
- +Trustpilot 4.4-star rating across 1,000+ reviews and 4.8-star Google rating signal real-world adoption (20,000+ patients reported, 1,000+ enrollments in last 7 days per their site)
Cons
- −Compounded-only — no FDA-approved Wegovy, Zepbound, Ozempic, Mounjaro, or Foundayo; no oral semaglutide tablet or sublingual format
- −Best pricing requires 6-month commitment (BNPL helps but the discount tier is locked to longer plans — month-to-month is materially higher)
- −No live tele-visit option in the standard intake — purely asynchronous review, which trades clinical depth for speed
- −Founding year, corporate headquarters city, and compounding pharmacy partner names are not publicly disclosed
- −B12 supplementation is not part of the standard formulation (some competitors like PeterMD include it; Yucca markets the products as 'Semaglutide+' and 'Tirzepatide+' but does not specify what the '+' represents)
- −Refund policy referenced on the site but not detailed in public-facing terms — verify before paying for the 6-month plan
Our Verdict
Calibrate and Yucca Health are closely matched with identical scores of 7.7/10. If budget is your priority, Yucca Health starts at $146/mo compared to Calibrate's $199/mo. Calibrate accepts insurance, which can significantly reduce your out-of-pocket costs. Calibrate offers both brand-name and compounded medications, giving you more flexibility. Choose Calibrate if you want: users who want a physician-led metabolic health program with a 3-month commitment and a weight-loss guarantee. Choose Yucca Health if you want: cash-pay patients who want a quick 24-hour async approval for compounded semaglutide or tirzepatide with disclosed prescribing physicians, ups 2-day shipping, and klarna/affirm/afterpay buy-now-pay-later options on longer commitments.