Calibrate vs Enhance MD: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

52 providers verified independently·Independent research·How we rank →

Visit Enhance MD - our pick of these two→or find your match

Enhance MD beats Calibrate overall, scoring 7.8/10 vs 7.7/10. Calibrate is more affordable at $199/mo vs $212/mo. Choose Calibrate for users who want a physician-led metabolic health program with. Choose Enhance MD for budget-conscious users interested in combination therapies.

A side-by-side look at Calibrate and Enhance MD to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Calibrate

#19 of 52

7.7/10

Metabolic health company offering a physician-led GLP-1 program restructured in 2026: $199/mo with a 3-month minimum commitment (no more $1,649 one-time enrollment fee). Includes nutrition coaching, labs, a smart scale, and a 10%+ weight-loss guarantee with 50% money-back.

Visit Calibrate

Higher Rated

Enhance MD

#16 of 52

7.8/10

Affordable telehealth provider offering both compounded and brand-name GLP-1 medications with combination therapy options.

Visit Enhance MD

Feature	Calibrate	Enhance MD
Our Score	7.7/10	7.8/10
Starting Price	$199/mo	$212/mo
Medication Type	Both	Both
Insurance Accepted	Yes	No
Best For	Users who want a physician-led metabolic health program with a 3-month commitment and a weight-loss guarantee	Budget-conscious users interested in combination therapies
Ranking	#19	#16
Get started	Visit Calibrate	Visit Enhance MD

Pros & Cons Compared

Calibrate

Pros

+2026 pricing rewrite, flat $199/mo with 3-month commitment ($597 upfront), then month-to-month. The old $1,649 one-time enrollment fee was removed.
+Board-certified physicians with metabolic health specialization lead treatment
+10%+ body-weight-loss guarantee with 50% money-back if not met
+Includes labs, nutrition coaching, personalized smart scale, and sleep/exercise support

Cons

−$597 upfront (3-month commitment) is a meaningful barrier vs. month-to-month competitors
−Medication cost is separate and varies significantly by payer route
−Fewer medications in the menu than larger marketplaces like Ro or Found
−Onboarding still takes 2-3 weeks to complete baseline labs and treatment plan

Enhance MD

Pros

+GLP-1 from $49 your first month, then $212/mo, with access to both brand-name and compounded; wafers as low as $84/mo on the 6-month plan
+Offers combination therapies (GLP-1 + B12, GLP-1 + NAD+) for patients wanting enhanced protocols
+Quick asynchronous consultations, most patients approved within 24 hours without video calls
+Flexible dosing: can start at lower doses than standard protocols for sensitive patients

Cons

−Check-ins are patient-initiated rather than scheduled; portal requests are usually answered within 24 hours, but you drive the cadence
−No insurance billing, and customer support runs business days only, no weekends

Our Verdict

Enhance MD edges out Calibrate with a score of 7.8/10 vs 7.7/10. If budget is your priority, Calibrate starts at $199/mo compared to Enhance MD's $212/mo. Calibrate accepts insurance, which can significantly reduce your out-of-pocket costs. Choose Calibrate if you want: users who want a physician-led metabolic health program with a 3-month commitment and a weight-loss guarantee. Choose Enhance MD if you want: budget-conscious users interested in combination therapies.

Still undecided? Editor's Featured Pick

Yucca Health

$146/mo · 7.7/10 · Compounded

If neither Calibrate nor Enhance MD feels like the right fit, our featured pick across all 52 GLP-1 telehealth providers is Yucca Health. It is not the highest-scored provider in our full rankings. We feature it for its low-friction value: a flat $146/mo that stays the same at every dose.

Visit Yucca Health→Read our full Yucca Health review