MyStart Health vs Yucca Health: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

49 providers verified independently·Independent research·How we rank →

MyStart Health and Yucca Health are tied at 7.7/10. Yucca Health is more affordable at $146/mo vs $299/mo. Choose MyStart Health for users who value a money-back weight-loss guarantee and price. Choose Yucca Health for people who'll commit to a 6-month plan for $146/mo, want nam.

A side-by-side comparison of MyStart Health and Yucca Health covering pricing, scores, medication types, insurance, and more to help you decide.

MyStart Health

#23 of 49

7.7/10

GLP-1 provider offering a unique money-back guarantee and price-lock protection for long-term cost certainty.

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Yucca Health

#19 of 49

7.7/10

Online weight-loss program by Yucca Health, Inc. (Beverly Hills, CA). Two named board-certified doctors — Dr. Michael Wasef MD and Dr. Andrew Sakla DO — handle prescribing. 20,000+ patients, 4.6 stars across 1,065 verified Trustpilot reviews. Starts at $146/mo for compounded semaglutide (custom-made version, not the FDA-approved brand) on the 6-month plan. Buy-now-pay-later via Klarna, Affirm, or Afterpay spreads the upfront commitment.

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Feature	MyStart Health	Yucca Health
Our Score	7.7/10	7.7/10
Starting Price	$299/mo	$146/mo
Medication Type	Compounded	Compounded
Insurance Accepted	No	No
Best For	Users who value a money-back weight-loss guarantee and price-lock protection	People who'll commit to a 6-month plan for $146/mo, want named doctors on record, and like buy-now-pay-later flexibility (Klarna/Affirm/Afterpay)
Ranking	#23	#19

Pros & Cons Compared

MyStart Health

Pros

+Price Lock Guarantee ensures your monthly rate never increases even as your GLP-1 dose escalates — a genuine differentiator
+Access to 600+ board-certified doctors with unlimited clinician messaging at no additional cost
+Competitive pricing at $149-$179/mo for compounded semaglutide with free shipping included
+HSA/FSA eligible — can use pre-tax health savings to pay for treatment

Cons

−Cash-pay only — no insurance accepted, which limits options for patients with GLP-1 coverage
−Only available in select states — not all 50, and the exact state list isn't published
−Compounded medications only — no brand-name GLP-1 options available

Yucca Health

Pros

+Two named board-certified doctors (Dr. Michael Wasef MD and Dr. Andrew Sakla DO) — most compounded GLP-1 providers don't publicly name their prescribers.
+4.6 stars across 1,065 verified Trustpilot reviews — 84% give 5 stars. Top complimented theme: customer service.
+Cheap if you commit: $146/mo for compounded semaglutide on the 6-month plan.
+Buy-now-pay-later through Klarna, Affirm, and Afterpay — unusual flexibility in this category, useful for spreading the 6-month upfront cost.
+24-hour async approval — no live video visit required. Faster onboarding than competitors that need a scheduled call.
+UPS 2-Day Air shipping included. Onboarding call from a real human (multiple Trustpilot reviewers name 'Hazel' and 'Johann' from the team).
+Replies to 100% of negative Trustpilot reviews, usually within 48 hours.

Cons

−Compounded-only — no FDA-approved Wegovy, Zepbound, Ozempic, or Mounjaro.
−The $146/mo price requires a 6-month upfront commitment. Month-to-month is meaningfully more expensive.
−No live tele-visit option — only async review. Faster, but less depth if you have a complex health history.
−Pharmacy partner not named publicly. Yucca says 'U.S. licensed pharmacies' but doesn't disclose which one.
−Founders and detailed company history not on the site.
−Refund policy is mentioned but not detailed publicly — verify the cancellation terms before paying for the 6-month plan.

Our Verdict

MyStart Health and Yucca Health are closely matched with identical scores of 7.7/10. If budget is your priority, Yucca Health starts at $146/mo compared to MyStart Health's $299/mo. Choose MyStart Health if you want: users who value a money-back weight-loss guarantee and price-lock protection. Choose Yucca Health if you want: people who'll commit to a 6-month plan for $146/mo, want named doctors on record, and like buy-now-pay-later flexibility (klarna/affirm/afterpay).

Still undecided? Editor's #1 Overall Pick

Embody

$299/mo · 7.3/10 · Compounded

If neither MyStart Health nor Yucca Health feels like the right fit, our overall #1 pick across all 49 GLP-1 telehealth providers is Embody — strongest balance of clinical oversight, transparent pricing, and verified availability.

Visit Embody→Read our full Embody review