MyStart Health vs Yucca Health: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

53 providers verified independently·Independent research·How we rank →

Visit MyStart Health - our pick of these two→or find your match

MyStart Health and Yucca Health are tied at 7.7/10. Yucca Health is more affordable at $146/mo vs $299/mo. Choose MyStart Health for users who want a monthly price that stays locked as their do. Choose Yucca Health for people who'll commit to a 6-month plan for $146/mo, want nam.

A side-by-side look at MyStart Health and Yucca Health to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

MyStart Health

#21 of 53

7.7/10

GLP-1 provider offering a unique money-back guarantee and price-lock protection for long-term cost certainty.

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Yucca Health

#17 of 53

7.7/10

Online weight-loss program by Yucca Health, Inc. (Beverly Hills, CA). Two named board-certified doctors, Dr. Michael Wasef MD and Dr. Andrew Sakla DO, handle prescribing. 20,000+ patients, 4.6 stars across 1,065 verified Trustpilot reviews. Starts at $146/mo for compounded semaglutide (custom-made version, not the FDA-approved brand) on the 6-month plan. Buy-now-pay-later via Klarna, Affirm, or Afterpay spreads the upfront commitment.

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Feature	MyStart Health	Yucca Health
Our Score	7.7/10	7.7/10
Starting Price	$299/mo	$146/mo
Medication Type	Compounded	Compounded
Insurance Accepted	No	No
Best For	Users who want a monthly price that stays locked as their dose increases, backed by a money-back weight-loss guarantee	People who'll commit to a 6-month plan for $146/mo, want named doctors on record, and like buy-now-pay-later flexibility (Klarna/Affirm/Afterpay)
Watch out for	Cash-pay only, no insurance accepted. If your plan covers GLP-1s, price that route first; HSA/FSA cards do work here	Compounded-only, no FDA-approved Wegovy, Zepbound, Ozempic, or Mounjaro.
Ranking	#21	#17
Get started	Visit MyStart Health	Visit Yucca Health

Pros & Cons Compared

MyStart Health

Pros

+Price Lock Guarantee ensures your monthly rate never increases even as your GLP-1 dose escalates, a genuine differentiator
+Competitive pricing at $149-$179/mo for compounded semaglutide with free shipping included
+Access to 600+ board-certified doctors with unlimited clinician messaging at no additional cost
+HSA/FSA eligible, can use pre-tax health savings to pay for treatment

Cons

−Cash-pay only, no insurance accepted. If your plan covers GLP-1s, price that route first; HSA/FSA cards do work here
−Select states only, not all 50, and the exact list isn't published. Confirm your state during the intake quiz before paying
−Compounded medications only, no brand-name GLP-1 option on the menu

Yucca Health

Pros

+Two named board-certified doctors (Dr. Michael Wasef MD and Dr. Andrew Sakla DO), most compounded GLP-1 providers don't publicly name their prescribers.
+4.6 stars across 1,065 verified Trustpilot reviews, 84% give 5 stars. Top complimented theme: customer service.
+Cheap if you commit: $146/mo for compounded semaglutide on the 6-month plan.
+Buy-now-pay-later through Klarna, Affirm, and Afterpay, unusual flexibility in this category, useful for spreading the 6-month upfront cost.
+24-hour async approval, no live video visit required. Faster onboarding than competitors that need a scheduled call.
+UPS 2-Day Air shipping included. Onboarding call from a real human (multiple Trustpilot reviewers name 'Hazel' and 'Johann' from the team).
+Replies to 100% of negative Trustpilot reviews, usually within 48 hours.

Cons

−Compounded-only, no FDA-approved Wegovy, Zepbound, Ozempic, or Mounjaro.
−The $146/mo price requires a 6-month upfront commitment (month-to-month is meaningfully more expensive). The Klarna/Affirm/Afterpay financing exists to spread exactly that upfront cost.
−No live tele-visit option, only async review. Faster, but less depth if you have a complex health history and want a provider you can talk to.
−Pharmacy partner not named publicly. Yucca says 'U.S. licensed pharmacies' but doesn't disclose which one.
−Founders and detailed company history not on the site.
−Refund policy is mentioned but not detailed publicly, get the cancellation terms in writing before paying for the 6-month plan.

Our Verdict

MyStart Health and Yucca Health are closely matched with identical scores of 7.7/10. If budget is your priority, Yucca Health starts at $146/mo compared to MyStart Health's $299/mo. Choose MyStart Health if you want: users who want a monthly price that stays locked as their dose increases, backed by a money-back weight-loss guarantee. Choose Yucca Health if you want: people who'll commit to a 6-month plan for $146/mo, want named doctors on record, and like buy-now-pay-later flexibility (klarna/affirm/afterpay).

Still undecided? Editor's Featured Pick

TrimRx

$149/mo · 7.8/10 · Compounded

If neither MyStart Health nor Yucca Health feels like the right fit, our featured pick across all 53 GLP-1 telehealth providers is TrimRx. It is not the highest-scored provider in our full rankings. We feature it for its low-friction value: a flat $149/mo that stays the same at every dose.

Visit TrimRx→Read our full TrimRx review