MyStart Health vs Willow: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher & Publisher

Reviewed & updated August 14, 2026 · Cites primary sources (FDA, NEJM, CMS) · Not medical advice

54 providers verified independently·Independent research·How we rank →

Short answer: MyStart Health scores higher on our rubric, 7.7/10 against 7.5/10. Full reasoning, pricing and the cases where the other one wins are below.

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MyStart Health beats Willow overall, scoring 7.7/10 vs 7.5/10. Choose MyStart Health for users who want a monthly price that stays locked as their dose increases, backed by a money-back weight-loss guarantee. Choose Willow for users who want comprehensive clinical support with flexibility between injectable and oral compounded semaglutide routes.

A side-by-side look at MyStart Health and Willow to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Higher Rated

MyStart Health

#17 of 54

7.7/10

GLP-1 provider offering a unique money-back guarantee and price-lock protection for long-term cost certainty.

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Willow

#20 of 54

7.5/10

Personalized GLP-1 weight loss with ongoing clinical support. Compounded semaglutide and tirzepatide only, Willow explicitly does not prescribe brand-name Wegovy or Zepbound. Added oral compounded semaglutide tablets as a non-injectable option.

Visit Willow

Feature	MyStart Health	Willow
Why each one	Price Lock Guarantee ensures your monthly rate never increases even as your dose escalates, plus access to 600+ board-certified doctors.	One of the few compounded-only platforms offering both injectable and daily oral semaglutide tablets, useful for users who want a non-injectable option without leaving the GLP-1 compounded category.
Our Score	7.7/10	7.5/10
Headline Price	from $299/mo	from $299/mo
Medication Type	Compounded	Compounded
Insurance Accepted	No	No
Best For	Users who want a monthly price that stays locked as their dose increases, backed by a money-back weight-loss guarantee	Users who want comprehensive clinical support with flexibility between injectable and oral compounded semaglutide routes
Watch out for	Cash-pay only, no insurance accepted. If your plan covers GLP-1s, price that route first; HSA/FSA cards do work here	Compounded-only, no brand-name Wegovy or Zepbound through the platform
Ranking	#17	#20
Get started	Visit MyStart Health	Visit Willow

Pros & Cons Compared

MyStart Health

Pros

+Price Lock Guarantee ensures your monthly rate never increases even as your GLP-1 dose escalates, a genuine differentiator
+Competitive pricing at $149-$179/mo for compounded semaglutide with free shipping included
+Access to 600+ board-certified doctors with unlimited clinician messaging at no additional cost
+HSA/FSA eligible, can use pre-tax health savings to pay for treatment

Cons

−Cash-pay only, no insurance accepted. If your plan covers GLP-1s, price that route first; HSA/FSA cards do work here
−Select states only, not all 50, and the exact list isn't published. Confirm your state during the intake quiz before paying
−Compounded medications only, no brand-name GLP-1 option on the menu

Willow

Pros

+Includes monthly provider check-ins and dose adjustments at no extra cost
+Offers both injectable AND oral compounded semaglutide, one of few platforms with a daily oral tablet option
+$299/mo all-in for compounded semaglutide with monthly provider support
+90%+ patient retention rate after 3 months per their published outcomes data

Cons

−Compounded-only, no brand-name Wegovy or Zepbound through the platform
−Tirzepatide pricing reaches $499-$524 at higher doses, starting dose is $399/mo
−Cash-pay only, no insurance billing, though they provide superbills for FSA/HSA
−Founded in 2024, less track record than Ro or Hims, though growth has been fast

Our Verdict

MyStart Health edges out Willow with a score of 7.7/10 vs 7.5/10.

Cheapest complete recurring price in our index

Trimi Health

$175/mo month-to-month, from $99 on a plan · 4.2/10 · Compounded

Both MyStart Health and Willow start above the cheapest complete recurring program we track. Across all 54 providers in our index, the lowest price with affirmative medication, consultation, and shipping inclusion is Trimi Health at $175/mo. It scores 4.2/10 and is not the highest-scored provider in our full rankings, so this is a cost floor rather than a recommendation. Worth knowing before you decide.