SynergyRx vs Yucca Health: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

49 providers verified independently·Independent research·How we rank →

Yucca Health beats SynergyRx overall, scoring 7.7/10 vs 7.6/10. Yucca Health is more affordable at $146/mo vs $199/mo. Choose SynergyRx for users who want predictable bundled pricing with 24/7 support. Choose Yucca Health for people who'll commit to a 6-month plan for $146/mo, want nam.

A side-by-side comparison of SynergyRx and Yucca Health covering pricing, scores, medication types, insurance, and more to help you decide.

SynergyRx

#24 of 49

7.6/10

Bundled GLP-1 program with predictable pricing and round-the-clock support access for peace of mind.

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Higher Rated

Yucca Health

#19 of 49

7.7/10

Online weight-loss program by Yucca Health, Inc. (Beverly Hills, CA). Two named board-certified doctors — Dr. Michael Wasef MD and Dr. Andrew Sakla DO — handle prescribing. 20,000+ patients, 4.6 stars across 1,065 verified Trustpilot reviews. Starts at $146/mo for compounded semaglutide (custom-made version, not the FDA-approved brand) on the 6-month plan. Buy-now-pay-later via Klarna, Affirm, or Afterpay spreads the upfront commitment.

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Feature	SynergyRx	Yucca Health
Our Score	7.6/10	7.7/10
Starting Price	$199/mo	$146/mo
Medication Type	Both	Compounded
Insurance Accepted	No	No
Best For	Users who want predictable bundled pricing with 24/7 support access	People who'll commit to a 6-month plan for $146/mo, want named doctors on record, and like buy-now-pay-later flexibility (Klarna/Affirm/Afterpay)
Ranking	#24	#19

Pros & Cons Compared

SynergyRx

Pros

+Oral dissolving tablets for BOTH semaglutide AND tirzepatide — one of the few platforms with needle-free tirzepatide
+Free expedited shipping included with all orders
+24/7 support with unlimited messaging — no per-visit fees for follow-up questions or dose adjustments
+Both compounded and brand-name options available (Ozempic, Wegovy, Mounjaro)

Cons

−Casper, WY registration address and limited independent reviews raise legitimacy questions
−Brand-name pricing ($499-947/mo) is very high compared to direct manufacturer programs like LillyDirect
−Company history, founding date, and ownership structure are not publicly disclosed

Yucca Health

Pros

+Two named board-certified doctors (Dr. Michael Wasef MD and Dr. Andrew Sakla DO) — most compounded GLP-1 providers don't publicly name their prescribers.
+4.6 stars across 1,065 verified Trustpilot reviews — 84% give 5 stars. Top complimented theme: customer service.
+Cheap if you commit: $146/mo for compounded semaglutide on the 6-month plan.
+Buy-now-pay-later through Klarna, Affirm, and Afterpay — unusual flexibility in this category, useful for spreading the 6-month upfront cost.
+24-hour async approval — no live video visit required. Faster onboarding than competitors that need a scheduled call.
+UPS 2-Day Air shipping included. Onboarding call from a real human (multiple Trustpilot reviewers name 'Hazel' and 'Johann' from the team).
+Replies to 100% of negative Trustpilot reviews, usually within 48 hours.

Cons

−Compounded-only — no FDA-approved Wegovy, Zepbound, Ozempic, or Mounjaro.
−The $146/mo price requires a 6-month upfront commitment. Month-to-month is meaningfully more expensive.
−No live tele-visit option — only async review. Faster, but less depth if you have a complex health history.
−Pharmacy partner not named publicly. Yucca says 'U.S. licensed pharmacies' but doesn't disclose which one.
−Founders and detailed company history not on the site.
−Refund policy is mentioned but not detailed publicly — verify the cancellation terms before paying for the 6-month plan.

Our Verdict

Yucca Health edges out SynergyRx with a score of 7.7/10 vs 7.6/10. If budget is your priority, Yucca Health starts at $146/mo compared to SynergyRx's $199/mo. SynergyRx offers both brand-name and compounded medications, giving you more flexibility. Choose SynergyRx if you want: users who want predictable bundled pricing with 24/7 support access. Choose Yucca Health if you want: people who'll commit to a 6-month plan for $146/mo, want named doctors on record, and like buy-now-pay-later flexibility (klarna/affirm/afterpay).

Still undecided? Editor's #1 Overall Pick

Embody

$299/mo · 7.3/10 · Compounded

If neither SynergyRx nor Yucca Health feels like the right fit, our overall #1 pick across all 49 GLP-1 telehealth providers is Embody — strongest balance of clinical oversight, transparent pricing, and verified availability.

Visit Embody→Read our full Embody review