SynergyRx vs Yucca Health: Which GLP-1 Provider Is Better?
By Iacob Pastina, Independent Researcher
Yucca Health beats SynergyRx overall, scoring 7.7/10 vs 7.6/10. Yucca Health is more affordable at $146/mo vs $199/mo. Choose SynergyRx for needle-phobic users who want oral dissolving tablets for sem. Choose Yucca Health for people who'll commit to a 6-month plan for $146/mo, want nam.
A side-by-side look at SynergyRx and Yucca Health to help you decide. We compare them on:
- •Starting price per month
- •Our overall score, out of 10
- •Medication type, brand-name or compounded
- •Whether they accept insurance
- •Who each one is best for
SynergyRx
#22 of 53Bundled GLP-1 program with predictable pricing and round-the-clock support access for peace of mind.
Visit SynergyRxYucca Health
#17 of 53Online weight-loss program by Yucca Health, Inc. (Beverly Hills, CA). Two named board-certified doctors, Dr. Michael Wasef MD and Dr. Andrew Sakla DO, handle prescribing. 20,000+ patients, 4.6 stars across 1,065 verified Trustpilot reviews. Starts at $146/mo for compounded semaglutide (custom-made version, not the FDA-approved brand) on the 6-month plan. Buy-now-pay-later via Klarna, Affirm, or Afterpay spreads the upfront commitment.
Visit Yucca Health| Feature | SynergyRx | Yucca Health |
|---|---|---|
| Our Score | 7.6/10 | 7.7/10 |
| Starting Price | $199/mo | $146/mo |
| Medication Type | Both | Compounded |
| Insurance Accepted | No | No |
| Best For | Needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included | People who'll commit to a 6-month plan for $146/mo, want named doctors on record, and like buy-now-pay-later flexibility (Klarna/Affirm/Afterpay) |
| Watch out for | Registered at a Casper, WY address with limited independent reviews. Verify pharmacy partners and provider credentials before enrolling. | Compounded-only, no FDA-approved Wegovy, Zepbound, Ozempic, or Mounjaro. |
| Ranking | #22 | #17 |
| Get started | Visit SynergyRx | Visit Yucca Health |
Pros & Cons Compared
SynergyRx
Pros
- +Oral dissolving tablets for BOTH semaglutide AND tirzepatide, one of the few platforms with needle-free tirzepatide
- +Free expedited shipping included with all orders
- +24/7 support with unlimited messaging, no per-visit fees for follow-up questions or dose adjustments
- +Both compounded and brand-name options available (Ozempic, Wegovy, Mounjaro)
Cons
- −Registered at a Casper, WY address with limited independent reviews. Verify pharmacy partners and provider credentials before enrolling.
- −Brand-name pricing ($499-947/mo) is very high compared to direct manufacturer programs like LillyDirect. Use SynergyRx for its compounded oral tablets; source brand-name directly if that's what you need.
- −Company history, founding date, and ownership structure are not publicly disclosed. Ask support for pharmacy and prescriber details upfront.
Yucca Health
Pros
- +Two named board-certified doctors (Dr. Michael Wasef MD and Dr. Andrew Sakla DO), most compounded GLP-1 providers don't publicly name their prescribers.
- +4.6 stars across 1,065 verified Trustpilot reviews, 84% give 5 stars. Top complimented theme: customer service.
- +Cheap if you commit: $146/mo for compounded semaglutide on the 6-month plan.
- +Buy-now-pay-later through Klarna, Affirm, and Afterpay, unusual flexibility in this category, useful for spreading the 6-month upfront cost.
- +24-hour async approval, no live video visit required. Faster onboarding than competitors that need a scheduled call.
- +UPS 2-Day Air shipping included. Onboarding call from a real human (multiple Trustpilot reviewers name 'Hazel' and 'Johann' from the team).
- +Replies to 100% of negative Trustpilot reviews, usually within 48 hours.
Cons
- −Compounded-only, no FDA-approved Wegovy, Zepbound, Ozempic, or Mounjaro.
- −The $146/mo price requires a 6-month upfront commitment (month-to-month is meaningfully more expensive). The Klarna/Affirm/Afterpay financing exists to spread exactly that upfront cost.
- −No live tele-visit option, only async review. Faster, but less depth if you have a complex health history and want a provider you can talk to.
- −Pharmacy partner not named publicly. Yucca says 'U.S. licensed pharmacies' but doesn't disclose which one.
- −Founders and detailed company history not on the site.
- −Refund policy is mentioned but not detailed publicly, get the cancellation terms in writing before paying for the 6-month plan.
Our Verdict
Yucca Health edges out SynergyRx with a score of 7.7/10 vs 7.6/10. If budget is your priority, Yucca Health starts at $146/mo compared to SynergyRx's $199/mo. SynergyRx offers both brand-name and compounded medications, giving you more flexibility. Choose SynergyRx if you want: needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included. Choose Yucca Health if you want: people who'll commit to a 6-month plan for $146/mo, want named doctors on record, and like buy-now-pay-later flexibility (klarna/affirm/afterpay).
Still undecided? Editor's Featured Pick
TrimRx
$149/mo · 7.8/10 · Compounded
If neither SynergyRx nor Yucca Health feels like the right fit, our featured pick across all 53 GLP-1 telehealth providers is TrimRx. It is not the highest-scored provider in our full rankings. We feature it for its low-friction value: a flat $149/mo that stays the same at every dose.
Read Full Reviews
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