Visit Enhance MDResearched against FDA labeling, published clinical-trial data (STEP-1 / SURMOUNT-1), and Enhance MD's live pages, not a paid placement.
Enhance MD GLP-1 Review
Affordable telehealth provider offering both compounded and brand-name GLP-1 medications with combination therapy options.
Enhance MD is the smart budget choice for self-directed users who know what they want. Full verdict ↓
Clinical evidence: 20.9% average body-weight reduction at 72 weeks in SURMOUNT-1 (NEJM, 2022). Individual results vary; compounded GLP-1s are not FDA-approved.
Summarize this article with
Enhance MD scores 7.8/10 in our independent review, starting at $212/mo for brand-name and compounded GLP-1 medications. Enhance MD is the budget pick for access to both medication types: GLP-1 at $49 your first month, then $212/mo, with wafers from $84/mo on the 6-month plan. Trustpilot rates it 4.
What makes it different: The most affordable platform offering both medication types plus unique combination therapies (GLP-1 + B12, GLP-1 + NAD+) that no other major provider offers at this price.
At a glance
- Budget-conscious users who still want medication variety
- Experienced GLP-1 users transferring from another provider
- Those interested in combination therapies (B12, NAD+ add-ons)
- First-time GLP-1 users who want structured clinical support
- Those who need weekend customer support
- Patients who prefer scheduled check-ins over self-directed care
Enhance MD Pros and Cons
What We Like
- +GLP-1 from $49 your first month, then $212/mo, with access to both brand-name and compounded; wafers as low as $84/mo on the 6-month plan
- +Offers combination therapies (GLP-1 + B12, GLP-1 + NAD+) for patients wanting enhanced protocols
- +Quick asynchronous consultations, most patients approved within 24 hours without video calls
- +Flexible dosing: can start at lower doses than standard protocols for sensitive patients
What Could Be Better
- −Check-ins are patient-initiated rather than scheduled; portal requests are usually answered within 24 hours, but you drive the cadence
- −No insurance billing, and customer support runs business days only, no weekends
What it costs
Headline pricing, full-year math, and how Enhance MD compares to the closest alternatives.
Quick facts
All pricing tiers
Compounded Semaglutide (first month)
$49/moIntroductory first-month rate for compounded semaglutide
Compounded Semaglutide (ongoing)
$212/moStandard monthly rate for compounded semaglutide with async consultations and free shipping
Compounded Tirzepatide (first month)
$99/moIntroductory first-month rate for compounded tirzepatide
Compounded Tirzepatide (ongoing)
$280/moStandard monthly rate for compounded tirzepatide
Elite Bundle (sema + tirz)
$322/moCombined semaglutide + tirzepatide bundle, $189 first month
Microdose Tirzepatide
$169/moLow-dose compounded tirzepatide for sensitive users or maintenance
NAD+ Therapy (subcutaneous)
$169/moNAD+ injection therapy, separate product line, not a GLP-1
Brand-Name GLP-1
$299/moFDA-approved Wegovy or Zepbound with basic clinical support
Cancellation policy: Cancel anytime, no commitment
What third-party review aggregators say about Enhance MD. Cards show the verified primary metric only, “Not found” means no public profile surfaced in our verification pass.
Enhance.MD carries a solid 4.1/5 TrustScore on Trustpilot (rated "Great") with generally positive feedback on flat pricing, nurse-practitioner access and easy onboarding. The recurring criticisms are medication delays/cancellations without clear explanation, shipments arriving from different pharmacies, and inconsistent potency/efficacy of the compounded formulation between months.
Reddit: Positive results reported (one user cited 98 lbs lost in 15 months) but recurring complaint that the compounded GLP-1 formulation feels less potent some months.
Trustpilot: Verified June 19, 2026, external-reviews verification pass.
Online Questionnaire
Complete a health assessment in about 10 minutes. Choose your preferred medication type and any combination therapy add-ons you're interested in.
Async Provider Approval
A provider reviews your assessment asynchronously, no video call needed. Most patients are approved within 24 hours.
Self-Directed Treatment
Medication ships free. You manage your treatment through the portal, reaching out to your provider when you need dose adjustments or have questions.
Medications available
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Visit Enhance MDSix trust signals, how we checked them, and what's been updated since the last review.
What the doctors say about GLP-1 medications
Independent, sourced clinical context on the medication class, not a comment on this provider.
“Thanks to the latest advancements in obesity management medications, more physicians and patients are witnessing significant weight reduction beyond what they have seen before. The SURMOUNT-5 head-to-head results demonstrated tirzepatide led to greater weight reduction compared to semaglutide, providing further evidence to support tirzepatide as an effective option for obesity.”
“Patients on both medications experienced substantial weight loss, and we observed no difference in the risk of gastrointestinal adverse events. In addition to effectiveness, factors like medication availability and insurance coverage will likely play a role in deciding which medication to initiate.”
Quotes are general medical commentary about GLP-1 medications, independently sourced and not solicited by GLP-1 Picks. They are not an endorsement of any provider, our provider scores are set solely by our published methodology.
Common questions
Questions readers ask about Enhance MD, similar providers to compare, and quick tools.
Frequently Asked Questions
What are the combination therapy options?+
Why is it so much cheaper than other platforms?+
Can I switch from compounded to brand-name?+
How do dose adjustments work without scheduled check-ins?+
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