Calibrate vs MyStart Health: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

48 providers verified independently·Independent research·How we rank →

Calibrate and MyStart Health are tied at 7.7/10. Calibrate is more affordable at $199/mo vs $299/mo. Choose Calibrate for users who want a physician-led metabolic health program with. Choose MyStart Health for users who value a money-back weight-loss guarantee and price.

A side-by-side comparison of Calibrate and MyStart Health covering pricing, scores, medication types, insurance, and more to help you decide.

Calibrate

#21 of 48

7.7/10

Metabolic health company offering a physician-led GLP-1 program restructured in 2026: $199/mo with a 3-month minimum commitment (no more $1,649 one-time enrollment fee). Includes nutrition coaching, labs, a smart scale, and a 10%+ weight-loss guarantee with 50% money-back.

Visit Calibrate

MyStart Health

#23 of 48

7.7/10

GLP-1 provider offering a unique money-back guarantee and price-lock protection for long-term cost certainty.

Visit MyStart Health

Feature	Calibrate	MyStart Health
Our Score	7.7/10	7.7/10
Starting Price	$199/mo	$299/mo
Medication Type	Both	Compounded
Insurance Accepted	Yes	No
Best For	Users who want a physician-led metabolic health program with a 3-month commitment and a weight-loss guarantee	Users who value a money-back weight-loss guarantee and price-lock protection
Ranking	#21	#23

Pros & Cons Compared

Calibrate

Pros

+2026 pricing rewrite — flat $199/mo with 3-month commitment ($597 upfront), then month-to-month. The old $1,649 one-time enrollment fee was removed.
+Board-certified physicians with metabolic health specialization lead treatment
+10%+ body-weight-loss guarantee with 50% money-back if not met
+Includes labs, nutrition coaching, personalized smart scale, and sleep/exercise support

Cons

−$597 upfront (3-month commitment) is a meaningful barrier vs. month-to-month competitors
−Medication cost is separate and varies significantly by payer route
−Fewer medications in the menu than larger marketplaces like Ro or Found
−Onboarding still takes 2-3 weeks to complete baseline labs and treatment plan

MyStart Health

Pros

+Price Lock Guarantee ensures your monthly rate never increases even as your GLP-1 dose escalates — a genuine differentiator
+Access to 600+ board-certified doctors with unlimited clinician messaging at no additional cost
+Competitive pricing at $149-$179/mo for compounded semaglutide with free shipping included
+HSA/FSA eligible — can use pre-tax health savings to pay for treatment

Cons

−Cash-pay only — no insurance accepted, which limits options for patients with GLP-1 coverage
−Only available in select states — not all 50, and the exact state list isn't published
−Compounded medications only — no brand-name GLP-1 options available

Our Verdict

Calibrate and MyStart Health are closely matched with identical scores of 7.7/10. If budget is your priority, Calibrate starts at $199/mo compared to MyStart Health's $299/mo. Calibrate accepts insurance, which can significantly reduce your out-of-pocket costs. Calibrate offers both brand-name and compounded medications, giving you more flexibility. Choose Calibrate if you want: users who want a physician-led metabolic health program with a 3-month commitment and a weight-loss guarantee. Choose MyStart Health if you want: users who value a money-back weight-loss guarantee and price-lock protection.

Still undecided? Editor's #1 Overall Pick

Embody

$299/mo · 7.3/10 · Compounded

If neither Calibrate nor MyStart Health feels like the right fit, our overall #1 pick across all 48 GLP-1 telehealth providers is Embody — strongest balance of clinical oversight, transparent pricing, and verified availability.

Visit Embody→Read our full Embody review