Enhance MD vs MyStart Health: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher & Publisher

Reviewed & updated August 14, 2026 · Cites primary sources (FDA, NEJM, CMS) · Not medical advice

54 providers verified independently·Independent research·How we rank →

Short answer: Enhance MD scores higher on our rubric, 7.8/10 against 7.7/10. Full reasoning, pricing and the cases where the other one wins are below.

Visit Enhance MD - our pick of these two →or find your match

Enhance MD beats MyStart Health overall, scoring 7.8/10 vs 7.7/10. Published pricing is not a like-for-like monthly comparison: Enhance MD is from $212/mo; MyStart Health is from $299/mo. Choose Enhance MD for budget-conscious users interested in combination therapies. Choose MyStart Health for users who want a monthly price that stays locked as their dose increases, backed by a money-back weight-loss guarantee.

A side-by-side look at Enhance MD and MyStart Health to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Higher Rated

Enhance MD

#13 of 54

7.8/10

Affordable telehealth provider offering both compounded and brand-name GLP-1 medications with combination therapy options.

Visit Enhance MD

MyStart Health

#17 of 54

7.7/10

GLP-1 provider offering a unique money-back guarantee and price-lock protection for long-term cost certainty.

Visit MyStart Health

Feature	Enhance MD	MyStart Health
Why each one	The most affordable platform offering both medication types plus unique combination therapies (GLP-1 + B12, GLP-1 + NAD+) that no other major provider offers at this price.	Price Lock Guarantee ensures your monthly rate never increases even as your dose escalates, plus access to 600+ board-certified doctors.
Our Score	7.8/10	7.7/10
Headline Price	from $212/mo	from $299/mo
Medication Type	Both	Compounded
Insurance Accepted	No	No
Best For	Budget-conscious users interested in combination therapies	Users who want a monthly price that stays locked as their dose increases, backed by a money-back weight-loss guarantee
Watch out for	Check-ins are patient-initiated rather than scheduled; portal requests are usually answered within 24 hours, but you drive the cadence	Cash-pay only, no insurance accepted. If your plan covers GLP-1s, price that route first; HSA/FSA cards do work here
Ranking	#13	#17
Get started	Visit Enhance MD	Visit MyStart Health

Pros & Cons Compared

Enhance MD

Pros

+GLP-1 from $49 your first month, then $212/mo, with access to both brand-name and compounded; wafers as low as $84/mo on the 6-month plan
+Offers combination therapies (GLP-1 + B12, GLP-1 + NAD+) for patients wanting enhanced protocols
+Quick asynchronous consultations, most patients approved within 24 hours without video calls
+Flexible dosing: can start at lower doses than standard protocols for sensitive patients

Cons

−Check-ins are patient-initiated rather than scheduled; portal requests are usually answered within 24 hours, but you drive the cadence
−No insurance billing, and customer support runs business days only, no weekends

MyStart Health

Pros

+Price Lock Guarantee ensures your monthly rate never increases even as your GLP-1 dose escalates, a genuine differentiator
+Competitive pricing at $149-$179/mo for compounded semaglutide with free shipping included
+Access to 600+ board-certified doctors with unlimited clinician messaging at no additional cost
+HSA/FSA eligible, can use pre-tax health savings to pay for treatment

Cons

−Cash-pay only, no insurance accepted. If your plan covers GLP-1s, price that route first; HSA/FSA cards do work here
−Select states only, not all 50, and the exact list isn't published. Confirm your state during the intake quiz before paying
−Compounded medications only, no brand-name GLP-1 option on the menu

Our Verdict

Enhance MD edges out MyStart Health with a score of 7.8/10 vs 7.7/10. Published pricing is not a like-for-like monthly comparison: Enhance MD is from $212/mo; MyStart Health is from $299/mo. Enhance MD offers both brand-name and compounded medications, giving you more flexibility.