Calibrate vs TrimRx: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

52 providers verified independently·Independent research·How we rank →

Visit TrimRx - our pick of these two→or find your match

TrimRx beats Calibrate overall, scoring 7.8/10 vs 7.7/10. TrimRx is more affordable at $149/mo vs $199/mo. Choose Calibrate for users who want a physician-led metabolic health program with. Choose TrimRx for users who want affordable compounded semaglutide at one flat.

A side-by-side look at Calibrate and TrimRx to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Calibrate

#19 of 52

7.7/10

Metabolic health company offering a physician-led GLP-1 program restructured in 2026: $199/mo with a 3-month minimum commitment (no more $1,649 one-time enrollment fee). Includes nutrition coaching, labs, a smart scale, and a 10%+ weight-loss guarantee with 50% money-back.

Visit Calibrate

Higher Rated

TrimRx

#11 of 52

7.8/10

Budget-friendly compounded GLP-1 provider with straightforward pricing and a focus on accessibility.

Visit TrimRx

Feature	Calibrate	TrimRx
Our Score	7.7/10	7.8/10
Starting Price	$199/mo	$149/mo
Medication Type	Both	Compounded
Insurance Accepted	Yes	No
Best For	Users who want a physician-led metabolic health program with a 3-month commitment and a weight-loss guarantee	Users who want affordable compounded semaglutide at one flat, all-inclusive price
Ranking	#19	#11
Get started	Visit Calibrate	Visit TrimRx

Pros & Cons Compared

Calibrate

Pros

+2026 pricing rewrite, flat $199/mo with 3-month commitment ($597 upfront), then month-to-month. The old $1,649 one-time enrollment fee was removed.
+Board-certified physicians with metabolic health specialization lead treatment
+10%+ body-weight-loss guarantee with 50% money-back if not met
+Includes labs, nutrition coaching, personalized smart scale, and sleep/exercise support

Cons

−$597 upfront (3-month commitment) is a meaningful barrier vs. month-to-month competitors
−Medication cost is separate and varies significantly by payer route
−Fewer medications in the menu than larger marketplaces like Ro or Found
−Onboarding still takes 2-3 weeks to complete baseline labs and treatment plan

TrimRx

Pros

+$149/mo all-inclusive for compounded semaglutide, one of the lowest prices for a full-service program
+Onboarding takes under 15 minutes with same-day provider review for most applications
+Free medication replacement if your shipment is lost or damaged in transit

Cons

−Compounded semaglutide is the only medication, no tirzepatide and no brand-name options. Pick TrimRx only if you already know semaglutide is your drug.
−No insurance billing and no superbill for out-of-network reimbursement, so treat the $149/mo as a pure cash-pay price

Our Verdict

TrimRx edges out Calibrate with a score of 7.8/10 vs 7.7/10. If budget is your priority, TrimRx starts at $149/mo compared to Calibrate's $199/mo. Calibrate accepts insurance, which can significantly reduce your out-of-pocket costs. Calibrate offers both brand-name and compounded medications, giving you more flexibility. Choose Calibrate if you want: users who want a physician-led metabolic health program with a 3-month commitment and a weight-loss guarantee. Choose TrimRx if you want: users who want affordable compounded semaglutide at one flat, all-inclusive price.

Still undecided? Editor's Featured Pick

Yucca Health

$146/mo · 7.7/10 · Compounded

If neither Calibrate nor TrimRx feels like the right fit, our featured pick across all 52 GLP-1 telehealth providers is Yucca Health. It is not the highest-scored provider in our full rankings. We feature it for its low-friction value: a flat $146/mo that stays the same at every dose.

Visit Yucca Health→Read our full Yucca Health review