Enhance MD vs Yucca Health: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

49 providers verified independently·Independent research·How we rank →

Enhance MD beats Yucca Health overall, scoring 7.8/10 vs 7.7/10. Yucca Health is more affordable at $146/mo vs $212/mo. Choose Enhance MD for budget-conscious users interested in combination therapies. Choose Yucca Health for people who'll commit to a 6-month plan for $146/mo, want nam.

A side-by-side comparison of Enhance MD and Yucca Health covering pricing, scores, medication types, insurance, and more to help you decide.

Higher Rated

Enhance MD

#18 of 49

7.8/10

Affordable telehealth provider offering both compounded and brand-name GLP-1 medications with combination therapy options.

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Yucca Health

#19 of 49

7.7/10

Online weight-loss program by Yucca Health, Inc. (Beverly Hills, CA). Two named board-certified doctors — Dr. Michael Wasef MD and Dr. Andrew Sakla DO — handle prescribing. 20,000+ patients, 4.6 stars across 1,065 verified Trustpilot reviews. Starts at $146/mo for compounded semaglutide (custom-made version, not the FDA-approved brand) on the 6-month plan. Buy-now-pay-later via Klarna, Affirm, or Afterpay spreads the upfront commitment.

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Feature	Enhance MD	Yucca Health
Our Score	7.8/10	7.7/10
Starting Price	$212/mo	$146/mo
Medication Type	Both	Compounded
Insurance Accepted	No	No
Best For	Budget-conscious users interested in combination therapies	People who'll commit to a 6-month plan for $146/mo, want named doctors on record, and like buy-now-pay-later flexibility (Klarna/Affirm/Afterpay)
Ranking	#18	#19

Pros & Cons Compared

Enhance MD

Pros

+$115/mo starting price with access to both brand-name and compounded — rare at this price point
+Offers combination therapies (GLP-1 + B12, GLP-1 + NAD+) for patients wanting enhanced protocols
+Quick asynchronous consultations — most patients approved within 24 hours without video calls
+Flexible dosing: can start at lower doses than standard protocols for sensitive patients

Cons

−Lighter clinical support than higher-priced platforms — check-ins are patient-initiated, not scheduled
−No insurance billing and limited customer support hours (business days only, no weekends)

Yucca Health

Pros

+Two named board-certified doctors (Dr. Michael Wasef MD and Dr. Andrew Sakla DO) — most compounded GLP-1 providers don't publicly name their prescribers.
+4.6 stars across 1,065 verified Trustpilot reviews — 84% give 5 stars. Top complimented theme: customer service.
+Cheap if you commit: $146/mo for compounded semaglutide on the 6-month plan.
+Buy-now-pay-later through Klarna, Affirm, and Afterpay — unusual flexibility in this category, useful for spreading the 6-month upfront cost.
+24-hour async approval — no live video visit required. Faster onboarding than competitors that need a scheduled call.
+UPS 2-Day Air shipping included. Onboarding call from a real human (multiple Trustpilot reviewers name 'Hazel' and 'Johann' from the team).
+Replies to 100% of negative Trustpilot reviews, usually within 48 hours.

Cons

−Compounded-only — no FDA-approved Wegovy, Zepbound, Ozempic, or Mounjaro.
−The $146/mo price requires a 6-month upfront commitment. Month-to-month is meaningfully more expensive.
−No live tele-visit option — only async review. Faster, but less depth if you have a complex health history.
−Pharmacy partner not named publicly. Yucca says 'U.S. licensed pharmacies' but doesn't disclose which one.
−Founders and detailed company history not on the site.
−Refund policy is mentioned but not detailed publicly — verify the cancellation terms before paying for the 6-month plan.

Our Verdict

Enhance MD edges out Yucca Health with a score of 7.8/10 vs 7.7/10. If budget is your priority, Yucca Health starts at $146/mo compared to Enhance MD's $212/mo. Enhance MD offers both brand-name and compounded medications, giving you more flexibility. Choose Enhance MD if you want: budget-conscious users interested in combination therapies. Choose Yucca Health if you want: people who'll commit to a 6-month plan for $146/mo, want named doctors on record, and like buy-now-pay-later flexibility (klarna/affirm/afterpay).

Still undecided? Editor's #1 Overall Pick

Embody

$299/mo · 7.3/10 · Compounded

If neither Enhance MD nor Yucca Health feels like the right fit, our overall #1 pick across all 49 GLP-1 telehealth providers is Embody — strongest balance of clinical oversight, transparent pricing, and verified availability.

Visit Embody→Read our full Embody review