MyStart Health vs Sesame Care: Which GLP-1 Provider Is Better?
Short answer: Sesame Care scores higher on our rubric, 7.9/10 against 5.7/10. Full reasoning, pricing and the cases where the other one wins are below.
Sesame Care beats MyStart Health overall, scoring 7.9/10 vs 5.7/10. Published pricing is not a like-for-like monthly comparison: MyStart Health is from $299/mo; Sesame Care is published $99/mo; total not verified. Choose MyStart Health for users who want a monthly price that stays locked as their dose increases, and who can live with a policy that refunds nothing once medication ships. Choose Sesame Care for users who want cheap fda-approved brand-name glp-1 access ($149-349/mo wegovy and zepbound via success by sesame), or insured patients who just need a prescriber.
A side-by-side look at MyStart Health and Sesame Care to help you decide. We compare them on:
- •Starting price per month
- •Our overall score, out of 10
- •Medication type, brand-name or compounded
- •Whether they accept insurance
- •Who each one is best for
MyStart Health
#43 of 54GLP-1 provider whose Price Lock Guarantee holds your monthly rate flat as your dose escalates, on an all-inclusive program that starts at $299 a month on its homepage FAQ.
Visit MyStart HealthSesame Care
#5 of 54Telehealth marketplace with two routes to a GLP-1 prescription: one-off video visits that start at $34 on the homepage, and the Success by Sesame subscription, which the weight loss program page prices at $59/mo on a 12-month commitment or $99 billed every 28 days with no commitment. It coordinates FDA-approved brand-name medication only, including Foundayo (orforglipron), the Wegovy pen and pill, and Zepbound. Medication is billed separately.
Visit Sesame Care| Feature | MyStart Health | Sesame Care |
|---|---|---|
| Why each one | Price Lock Guarantee ensures your monthly rate never increases even as your dose escalates, plus access to 600+ board-certified doctors. | The broadest FDA-approved brand-name GLP-1 menu among low-cost telehealth options, Wegovy pen and pill, Zepbound, Ozempic, Mounjaro, Rybelsus, and Foundayo, coordinated through the Success by Sesame membership at $59/mo on a 12-month commitment plus medication. |
| Our Score | 5.7/10 | 7.9/10 |
| Headline Price | from $299/mo | published $99/mo; total not verified |
| Medication Type | Compounded | Brand |
| Insurance Accepted | No | Yes |
| Best For | Users who want a monthly price that stays locked as their dose increases, and who can live with a policy that refunds nothing once medication ships | Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber |
| Watch out for | FDA warning letter 714755, issued September 9, 2025 to MyStart Health LLC, found the claims about compounded semaglutide on mystarthealth.com false or misleading under sections 502(a) and 502(bb) of the Food, Drug, and Cosmetic Act. It concerns marketing, not an allegation that the medication was unsafe, and no public close-out letter had been posted as of September 4, 2026 | Sesame runs three separate routes under one brand: the Success by Sesame weight loss subscription, EverydayRx for diabetes, and one-off visits from $34. Check which one you are signing up for before you pay. |
| Ranking | #43 | #5 |
| Get started | Visit MyStart Health | Visit Sesame Care |
Pros & Cons Compared
MyStart Health
Pros
- +Price Lock Guarantee ensures your monthly rate never increases even as your GLP-1 dose escalates, a genuine differentiator
- +All-inclusive $299 a month on the homepage FAQ, covering physician evaluations, unlimited clinician access, medication, blood work and shipping, with no membership fee on top
- +Access to 600+ board-certified doctors with unlimited clinician messaging at no additional cost
- +You are not charged if you do not qualify: the homepage FAQ promises a full refund within 24 to 48 hours if a doctor finds you ineligible, and a free video appointment in that case
Cons
- −FDA warning letter 714755, issued September 9, 2025 to MyStart Health LLC, found the claims about compounded semaglutide on mystarthealth.com false or misleading under sections 502(a) and 502(bb) of the Food, Drug, and Cosmetic Act. It concerns marketing, not an allegation that the medication was unsafe, and no public close-out letter had been posted as of September 4, 2026
- −Cash-pay only, no insurance accepted, and the only payment method the site names is a credit card. If your plan covers GLP-1s, price that route first
- −Nothing is refundable once your medication ships, including if you are dissatisfied or hit side effects, and returned medication is never accepted (refund policy effective December 1, 2025)
- −Compounded medications only, no brand-name GLP-1 option on the menu
Sesame Care
Pros
- +Success by Sesame is $59/mo on the 12-month commitment and includes provider visits, unlimited messaging and provider choice; lab work is covered only at Quest Diagnostics and not in AZ, HI, ND, NJ, NY, OK, RI, SD or WY, where lab fees are extra; medication is separate
- +Brand-name cash pricing is competitive, Wegovy pen $199 intro / $349 ongoing, Zepbound vial $299, Wegovy pill $149
- +Foundayo (Lilly's FDA-approved oral GLP-1) available as of April 2026 at $149/mo
- +The pay-per-visit route is still there, with visits starting at $34, for users who just need a prescriber
Cons
- −Sesame runs three separate routes under one brand: the Success by Sesame weight loss subscription, EverydayRx for diabetes, and one-off visits from $34. Check which one you are signing up for before you pay.
- −The $59/mo Success by Sesame rate applies only on a 12-month commitment. The 3-month plan works out near $79/mo and the 6-month near $69/mo from the savings the FAQ publishes, and the no-commitment plan is $99 billed every 28 days, which is 13 charges a year.
- −There is no compounded option. Sesame states that compounded semaglutide is not currently available through it, so every route here is brand-name and the medication is billed on top of the program fee.
- −A marketplace rather than a concierge, expect less hand-holding than dedicated subscription platforms
Our Verdict
Sesame Care edges out MyStart Health with a score of 7.9/10 vs 5.7/10. Published pricing is not a like-for-like monthly comparison: MyStart Health is from $299/mo; Sesame Care is published $99/mo; total not verified. Sesame Care accepts insurance, which can significantly reduce your out-of-pocket costs.
Read Full Reviews
Related comparisons
More head-to-head comparisons involving MyStart Health and Sesame Care.
Not comparing, just asking? Quick answers to the most-asked GLP-1 questions →
- Compare MyStart Health and Zealthyfrom $286/mo
- Compare MyStart Health and Sprout Health$110/mo flat
- Compare MyStart Health and Fridaysfrom $117/mo
- Compare Sesame Care and MangoRxfrom $299/mo
- Compare Sesame Care and Breeze Medsfrom $199/mo
- Compare Sesame Care and Shedfrom $159/mo
Not sure which one is right for you?
Answer a few quick questions and we'll match you to the best GLP-1 provider for your needs. Or keep exploring below.
Still working out whether either one is above board? We check that separately: is MyStart Health legit and is Sesame Care legit, with the verification evidence behind each answer.
Our pick of these two: Sesame Care · 7.9/10