MyStart Health vs Sesame Care: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher & Publisher

Reviewed & updated August 14, 2026 · Cites primary sources (FDA, NEJM, CMS) · Not medical advice

54 providers verified independently·Independent research·How we rank →

Short answer: Sesame Care scores higher on our rubric, 7.9/10 against 7.7/10. Full reasoning, pricing and the cases where the other one wins are below.

Visit Sesame Care - our pick of these two →or find your match

Sesame Care beats MyStart Health overall, scoring 7.9/10 vs 7.7/10. Published pricing is not a like-for-like monthly comparison: MyStart Health is from $299/mo; Sesame Care is published $99/mo; total not verified. Choose MyStart Health for users who want a monthly price that stays locked as their dose increases, backed by a money-back weight-loss guarantee. Choose Sesame Care for users who want cheap fda-approved brand-name glp-1 access ($149-349/mo wegovy and zepbound via success by sesame), or insured patients who just need a prescriber.

A side-by-side look at MyStart Health and Sesame Care to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

MyStart Health

#17 of 54

7.7/10

GLP-1 provider offering a unique money-back guarantee and price-lock protection for long-term cost certainty.

Visit MyStart Health

Higher Rated

Sesame Care

#5 of 54

7.9/10

Telehealth marketplace offering both a low-cost consultation model ($25/visit) and the new Success by Sesame membership program ($59/mo on 3/6/12-month plans), which coordinates access to FDA-approved brand-name GLP-1 medications including Foundayo (orforglipron), Wegovy pen and pill, and Zepbound. Medication is billed separately.

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Feature	MyStart Health	Sesame Care
Why each one	Price Lock Guarantee ensures your monthly rate never increases even as your dose escalates, plus access to 600+ board-certified doctors.	The broadest FDA-approved brand-name GLP-1 menu among low-cost telehealth options, Wegovy pen and pill, Zepbound, Ozempic, Mounjaro, Rybelsus, and Foundayo, coordinated through the new Success by Sesame membership at $59/mo plus medication.
Our Score	7.7/10	7.9/10
Headline Price	from $299/mo	published $99/mo; total not verified
Medication Type	Compounded	Both
Insurance Accepted	No	Yes
Best For	Users who want a monthly price that stays locked as their dose increases, backed by a money-back weight-loss guarantee	Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber
Watch out for	Cash-pay only, no insurance accepted. If your plan covers GLP-1s, price that route first; HSA/FSA cards do work here	Two distinct products (pay-per-visit vs the Success membership) sit side by side, so decide which you're buying before checkout
Ranking	#17	#5
Get started	Visit MyStart Health	Visit Sesame Care

Pros & Cons Compared

MyStart Health

Pros

+Price Lock Guarantee ensures your monthly rate never increases even as your GLP-1 dose escalates, a genuine differentiator
+Competitive pricing at $149-$179/mo for compounded semaglutide with free shipping included
+Access to 600+ board-certified doctors with unlimited clinician messaging at no additional cost
+HSA/FSA eligible, can use pre-tax health savings to pay for treatment

Cons

−Cash-pay only, no insurance accepted. If your plan covers GLP-1s, price that route first; HSA/FSA cards do work here
−Select states only, not all 50, and the exact list isn't published. Confirm your state during the intake quiz before paying
−Compounded medications only, no brand-name GLP-1 option on the menu

Sesame Care

Pros

+Success by Sesame program launched 2026, $59/mo on a 3/6/12-month plan, includes labs, unlimited messaging, and provider choice; medication is separate
+Brand-name cash pricing is competitive, Wegovy pen $199 intro / $349 ongoing, Zepbound vial $299, Wegovy pill $149
+Foundayo (Lilly's FDA-approved oral GLP-1) available as of April 2026 at $149/mo
+Original pay-per-visit model still available at $25/consultation for users who just need a prescriber

Cons

−Two distinct products (pay-per-visit vs the Success membership) sit side by side, so decide which you're buying before checkout
−The $59/mo Success by Sesame rate requires a 3-month minimum commitment; month-to-month is available at $99/mo if you don't want to commit
−Compounded meds are de-emphasized in the current marketing, the platform now leads with FDA-approved brand-name paths
−A marketplace rather than a concierge, expect less hand-holding than dedicated subscription platforms

Our Verdict

Sesame Care edges out MyStart Health with a score of 7.9/10 vs 7.7/10. Published pricing is not a like-for-like monthly comparison: MyStart Health is from $299/mo; Sesame Care is published $99/mo; total not verified. Sesame Care accepts insurance, which can significantly reduce your out-of-pocket costs. Sesame Care offers both brand-name and compounded medications, giving you more flexibility.