Direct Meds GLP-1 vs Sesame Care: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

48 providers verified independently·Independent research·How we rank →

Direct Meds GLP-1 and Sesame Care are tied at 7.9/10. Sesame Care is more affordable at $99/mo vs $297/mo. Choose Direct Meds GLP-1 for users wanting simple, all-inclusive pricing without insuranc. Choose Sesame Care for users who want cheap fda-approved brand-name glp-1 access ($.

A side-by-side comparison of Direct Meds GLP-1 and Sesame Care covering pricing, scores, medication types, insurance, and more to help you decide.

Direct Meds GLP-1

#13 of 48

7.9/10

Straightforward compounded GLP-1 program with transparent all-inclusive pricing and no hidden fees.

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Sesame Care

#10 of 48

7.9/10

Telehealth marketplace offering both a low-cost consultation model ($25/visit) and the new Success by Sesame membership program ($59/mo on 3/6/12-month plans) that bundles FDA-approved brand-name GLP-1 medications — including Foundayo (orforglipron), Wegovy pen and pill, and Zepbound.

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Feature	Direct Meds GLP-1	Sesame Care
Our Score	7.9/10	7.9/10
Starting Price	$297/mo	$99/mo
Medication Type	Compounded	Both
Insurance Accepted	No	Yes
Best For	Users wanting simple, all-inclusive pricing without insurance	Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber
Ranking	#13	#10

Pros & Cons Compared

Direct Meds GLP-1

Pros

+True all-inclusive pricing — $280/mo covers medication, consultations, shipping, and pharmacy fees with no add-ons
+Clear dose-based pricing published on their site — no surprise cost increases when titrating up
+Fast pharmacy fulfillment: most orders ship within 48 hours of provider approval
+Responsive customer support with live chat available during business hours

Cons

−Compounded medications only — cannot prescribe brand-name Wegovy, Zepbound, or Ozempic
−At $280/mo for compounded-only, it's pricier than competitors like Henry Meds ($199) or TrimRx ($179)

Sesame Care

Pros

+Success by Sesame program launched 2026 — $59/mo on a 3/6/12-month plan, bundles labs, unlimited messaging, and provider choice
+Brand-name cash pricing is competitive — Wegovy pen $199 intro / $349 ongoing, Zepbound vial $299, Wegovy pill $149
+Foundayo (Lilly's FDA-approved oral GLP-1) available as of April 2026 at $149/mo
+Original pay-per-visit model still available at $25/consultation for users who just need a prescriber

Cons

−Membership model adds complexity — two distinct products (pay-per-visit vs Success membership) can be confusing
−Success by Sesame requires a 3-month minimum commitment to hit the $59/mo rate
−Compounded meds are de-emphasized on the current marketing — focus has shifted to FDA-approved brand-name paths
−Less hand-holding than dedicated subscription platforms like Willow or Eden Health

Our Verdict

Direct Meds GLP-1 and Sesame Care are closely matched with identical scores of 7.9/10. If budget is your priority, Sesame Care starts at $99/mo compared to Direct Meds GLP-1's $297/mo. Sesame Care accepts insurance, which can significantly reduce your out-of-pocket costs. Sesame Care offers both brand-name and compounded medications, giving you more flexibility. Choose Direct Meds GLP-1 if you want: users wanting simple, all-inclusive pricing without insurance. Choose Sesame Care if you want: users who want cheap fda-approved brand-name glp-1 access ($149-349/mo wegovy and zepbound via success by sesame), or insured patients who just need a prescriber.

Still undecided? Editor's #1 Overall Pick

Eden Health GLP-1

$249/mo · 8.9/10 · Both

If neither Direct Meds GLP-1 nor Sesame Care feels like the right fit, our overall #1 pick across all 48 GLP-1 telehealth providers is Eden Health GLP-1 — strongest balance of clinical oversight, transparent pricing, and verified availability.

Visit Eden Health GLP-1→Read our full Eden Health GLP-1 review