Direct Meds GLP-1 vs Sesame Care: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

52 providers verified independently·Independent research·How we rank →

Direct Meds GLP-1 and Sesame Care are tied at 7.9/10. Sesame Care is more affordable at $99/mo vs $297/mo. Choose Direct Meds GLP-1 for users wanting simple, all-inclusive pricing without insuranc. Choose Sesame Care for users who want cheap fda-approved brand-name glp-1 access ($.

A side-by-side look at Direct Meds GLP-1 and Sesame Care to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Direct Meds GLP-1

#10 of 52

7.9/10

Straightforward compounded GLP-1 program with transparent all-inclusive pricing and no hidden fees.

Visit Direct Meds GLP-1

Sesame Care

#7 of 52

7.9/10

Telehealth marketplace offering both a low-cost consultation model ($25/visit) and the new Success by Sesame membership program ($59/mo on 3/6/12-month plans) that bundles FDA-approved brand-name GLP-1 medications, including Foundayo (orforglipron), Wegovy pen and pill, and Zepbound.

Visit Sesame Care

Feature	Direct Meds GLP-1	Sesame Care
Our Score	7.9/10	7.9/10
Starting Price	$297/mo	$99/mo
Medication Type	Compounded	Both
Insurance Accepted	No	Yes
Best For	Users wanting simple, all-inclusive pricing without insurance	Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber
Ranking	#10	#7
Get started	Visit Direct Meds GLP-1	Visit Sesame Care

Pros & Cons Compared

Direct Meds GLP-1

Pros

+True all-inclusive pricing, $280/mo covers medication, consultations, shipping, and pharmacy fees with no add-ons
+Clear dose-based pricing published on their site, no surprise cost increases when titrating up
+Fast pharmacy fulfillment: most orders ship within 48 hours of provider approval
+Responsive customer support with live chat available during business hours

Cons

−Compounded medications only, no brand-name Wegovy, Zepbound, or Ozempic on the menu
−The $280/mo flat rate sits above Henry Meds ($199) and TrimRx ($149); Direct Meds' own sublingual drops at $179 are the budget path if the premium stings

Sesame Care

Pros

+Success by Sesame program launched 2026, $59/mo on a 3/6/12-month plan, bundles labs, unlimited messaging, and provider choice
+Brand-name cash pricing is competitive, Wegovy pen $199 intro / $349 ongoing, Zepbound vial $299, Wegovy pill $149
+Foundayo (Lilly's FDA-approved oral GLP-1) available as of April 2026 at $149/mo
+Original pay-per-visit model still available at $25/consultation for users who just need a prescriber

Cons

−Two distinct products (pay-per-visit vs the Success membership) sit side by side, so decide which you're buying before checkout
−The $59/mo Success by Sesame rate requires a 3-month minimum commitment; month-to-month is available at $99/mo if you don't want to commit
−Compounded meds are de-emphasized in the current marketing, the platform now leads with FDA-approved brand-name paths
−A marketplace rather than a concierge, expect less hand-holding than dedicated subscription platforms

Our Verdict

Direct Meds GLP-1 and Sesame Care are closely matched with identical scores of 7.9/10. If budget is your priority, Sesame Care starts at $99/mo compared to Direct Meds GLP-1's $297/mo. Sesame Care accepts insurance, which can significantly reduce your out-of-pocket costs. Sesame Care offers both brand-name and compounded medications, giving you more flexibility. Choose Direct Meds GLP-1 if you want: users wanting simple, all-inclusive pricing without insurance. Choose Sesame Care if you want: users who want cheap fda-approved brand-name glp-1 access ($149-349/mo wegovy and zepbound via success by sesame), or insured patients who just need a prescriber.

Still undecided? Editor's Featured Pick

Yucca Health

$146/mo · 7.7/10 · Compounded

If neither Direct Meds GLP-1 nor Sesame Care feels like the right fit, our featured pick across all 52 GLP-1 telehealth providers is Yucca Health. It is not the highest-scored provider in our full rankings. We feature it for its low-friction value: a flat $146/mo that stays the same at every dose.

Visit Yucca Health→Read our full Yucca Health review