Direct Meds GLP-1 vs Enhance MD: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

48 providers verified independently·Independent research·How we rank →

Direct Meds GLP-1 beats Enhance MD overall, scoring 7.9/10 vs 7.8/10. Enhance MD is more affordable at $212/mo vs $297/mo. Choose Direct Meds GLP-1 for users wanting simple, all-inclusive pricing without insuranc. Choose Enhance MD for budget-conscious users interested in combination therapies.

A side-by-side comparison of Direct Meds GLP-1 and Enhance MD covering pricing, scores, medication types, insurance, and more to help you decide.

Higher Rated

Direct Meds GLP-1

#13 of 48

7.9/10

Straightforward compounded GLP-1 program with transparent all-inclusive pricing and no hidden fees.

Visit Direct Meds GLP-1

Enhance MD

#18 of 48

7.8/10

Affordable telehealth provider offering both compounded and brand-name GLP-1 medications with combination therapy options.

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Feature	Direct Meds GLP-1	Enhance MD
Our Score	7.9/10	7.8/10
Starting Price	$297/mo	$212/mo
Medication Type	Compounded	Both
Insurance Accepted	No	No
Best For	Users wanting simple, all-inclusive pricing without insurance	Budget-conscious users interested in combination therapies
Ranking	#13	#18

Pros & Cons Compared

Direct Meds GLP-1

Pros

+True all-inclusive pricing — $280/mo covers medication, consultations, shipping, and pharmacy fees with no add-ons
+Clear dose-based pricing published on their site — no surprise cost increases when titrating up
+Fast pharmacy fulfillment: most orders ship within 48 hours of provider approval
+Responsive customer support with live chat available during business hours

Cons

−Compounded medications only — cannot prescribe brand-name Wegovy, Zepbound, or Ozempic
−At $280/mo for compounded-only, it's pricier than competitors like Henry Meds ($199) or TrimRx ($179)

Enhance MD

Pros

+$115/mo starting price with access to both brand-name and compounded — rare at this price point
+Offers combination therapies (GLP-1 + B12, GLP-1 + NAD+) for patients wanting enhanced protocols
+Quick asynchronous consultations — most patients approved within 24 hours without video calls
+Flexible dosing: can start at lower doses than standard protocols for sensitive patients

Cons

−Lighter clinical support than higher-priced platforms — check-ins are patient-initiated, not scheduled
−No insurance billing and limited customer support hours (business days only, no weekends)

Our Verdict

Direct Meds GLP-1 edges out Enhance MD with a score of 7.9/10 vs 7.8/10. If budget is your priority, Enhance MD starts at $212/mo compared to Direct Meds GLP-1's $297/mo. Enhance MD offers both brand-name and compounded medications, giving you more flexibility. Choose Direct Meds GLP-1 if you want: users wanting simple, all-inclusive pricing without insurance. Choose Enhance MD if you want: budget-conscious users interested in combination therapies.

Still undecided? Editor's #1 Overall Pick

Eden Health GLP-1

$249/mo · 8.9/10 · Both

If neither Direct Meds GLP-1 nor Enhance MD feels like the right fit, our overall #1 pick across all 48 GLP-1 telehealth providers is Eden Health GLP-1 — strongest balance of clinical oversight, transparent pricing, and verified availability.

Visit Eden Health GLP-1→Read our full Eden Health GLP-1 review