Direct Meds GLP-1 vs Enhance MD: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

52 providers verified independently·Independent research·How we rank →

Direct Meds GLP-1 beats Enhance MD overall, scoring 7.9/10 vs 7.8/10. Enhance MD is more affordable at $212/mo vs $297/mo. Choose Direct Meds GLP-1 for users wanting simple, all-inclusive pricing without insuranc. Choose Enhance MD for budget-conscious users interested in combination therapies.

A side-by-side look at Direct Meds GLP-1 and Enhance MD to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Higher Rated

Direct Meds GLP-1

#10 of 52

7.9/10

Straightforward compounded GLP-1 program with transparent all-inclusive pricing and no hidden fees.

Visit Direct Meds GLP-1

Enhance MD

#16 of 52

7.8/10

Affordable telehealth provider offering both compounded and brand-name GLP-1 medications with combination therapy options.

Visit Enhance MD

Feature	Direct Meds GLP-1	Enhance MD
Our Score	7.9/10	7.8/10
Starting Price	$297/mo	$212/mo
Medication Type	Compounded	Both
Insurance Accepted	No	No
Best For	Users wanting simple, all-inclusive pricing without insurance	Budget-conscious users interested in combination therapies
Ranking	#10	#16
Get started	Visit Direct Meds GLP-1	Visit Enhance MD

Pros & Cons Compared

Direct Meds GLP-1

Pros

+True all-inclusive pricing, $280/mo covers medication, consultations, shipping, and pharmacy fees with no add-ons
+Clear dose-based pricing published on their site, no surprise cost increases when titrating up
+Fast pharmacy fulfillment: most orders ship within 48 hours of provider approval
+Responsive customer support with live chat available during business hours

Cons

−Compounded medications only, no brand-name Wegovy, Zepbound, or Ozempic on the menu
−The $280/mo flat rate sits above Henry Meds ($199) and TrimRx ($149); Direct Meds' own sublingual drops at $179 are the budget path if the premium stings

Enhance MD

Pros

+GLP-1 from $49 your first month, then $212/mo, with access to both brand-name and compounded; wafers as low as $84/mo on the 6-month plan
+Offers combination therapies (GLP-1 + B12, GLP-1 + NAD+) for patients wanting enhanced protocols
+Quick asynchronous consultations, most patients approved within 24 hours without video calls
+Flexible dosing: can start at lower doses than standard protocols for sensitive patients

Cons

−Check-ins are patient-initiated rather than scheduled; portal requests are usually answered within 24 hours, but you drive the cadence
−No insurance billing, and customer support runs business days only, no weekends

Our Verdict

Direct Meds GLP-1 edges out Enhance MD with a score of 7.9/10 vs 7.8/10. If budget is your priority, Enhance MD starts at $212/mo compared to Direct Meds GLP-1's $297/mo. Enhance MD offers both brand-name and compounded medications, giving you more flexibility. Choose Direct Meds GLP-1 if you want: users wanting simple, all-inclusive pricing without insurance. Choose Enhance MD if you want: budget-conscious users interested in combination therapies.

Still undecided? Editor's Featured Pick

Yucca Health

$146/mo · 7.7/10 · Compounded

If neither Direct Meds GLP-1 nor Enhance MD feels like the right fit, our featured pick across all 52 GLP-1 telehealth providers is Yucca Health. It is not the highest-scored provider in our full rankings. We feature it for its low-friction value: a flat $146/mo that stays the same at every dose.

Visit Yucca Health→Read our full Yucca Health review