Direct Meds GLP-1 vs Enhance MD: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher & Publisher

Reviewed & updated August 14, 2026 · Cites primary sources (FDA, NEJM, CMS) · Not medical advice

54 providers verified independently·Independent research·How we rank →

Short answer: Direct Meds GLP-1 scores higher on our rubric, 7.9/10 against 7.8/10. Full reasoning, pricing and the cases where the other one wins are below.

Visit Direct Meds GLP-1 - our pick of these two →or find your match

Direct Meds GLP-1 beats Enhance MD overall, scoring 7.9/10 vs 7.8/10. Published pricing is not a like-for-like monthly comparison: Direct Meds GLP-1 is from $297/mo; Enhance MD is from $212/mo. Choose Direct Meds GLP-1 for users who value published format-specific pricing and can independently monitor billing and cancellation. Choose Enhance MD for budget-conscious users interested in combination therapies.

A side-by-side look at Direct Meds GLP-1 and Enhance MD to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Higher Rated

Direct Meds GLP-1

#8 of 54

7.9/10

Compounded GLP-1 program with published format-specific prices, offset by a sharply negative BBB complaint record around billing, cancellation, and fulfillment.

Visit Direct Meds GLP-1

Enhance MD

#13 of 54

7.8/10

Affordable telehealth provider offering both compounded and brand-name GLP-1 medications with combination therapy options.

Visit Enhance MD

Feature	Direct Meds GLP-1	Enhance MD
Why each one	Thorough clinical consultations focused on medical-grade patient experience rather than quick-turnaround prescribing.	The most affordable platform offering both medication types plus unique combination therapies (GLP-1 + B12, GLP-1 + NAD+) that no other major provider offers at this price.
Our Score	7.9/10	7.8/10
Headline Price	from $297/mo	from $212/mo
Medication Type	Compounded	Both
Insurance Accepted	No	No
Best For	Users who value published format-specific pricing and can independently monitor billing and cancellation	Budget-conscious users interested in combination therapies
Watch out for	Compounded medications only, no brand-name Wegovy, Zepbound, or Ozempic on the menu	Check-ins are patient-initiated rather than scheduled; portal requests are usually answered within 24 hours, but you drive the cadence
Ranking	#8	#13
Get started	Visit Direct Meds GLP-1	Visit Enhance MD

Pros & Cons Compared

Direct Meds GLP-1

Pros

+The published $297/mo compounded semaglutide injection tier includes medication, consultations, shipping, and pharmacy fees
+Format-specific prices are published on the site, which makes the advertised medication and service bundle easier to compare
+Fast pharmacy fulfillment: most orders ship within 48 hours of provider approval
+Responsive customer support with live chat available during business hours

Cons

−Compounded medications only, no brand-name Wegovy, Zepbound, or Ozempic on the menu
−The $297/mo injectable semaglutide rate sits above Henry Meds ($199) and TrimRx (starting at $179); Direct Meds' own sublingual semaglutide drops at $179 are the budget path if the premium stings
−BBB shows 248 complaints and roughly 1.1/5 customer-review stars, with recurring reports of unauthorized charges, cancellation difficulty, billing confusion, and unfulfilled or delayed orders

Enhance MD

Pros

+GLP-1 from $49 your first month, then $212/mo, with access to both brand-name and compounded; wafers as low as $84/mo on the 6-month plan
+Offers combination therapies (GLP-1 + B12, GLP-1 + NAD+) for patients wanting enhanced protocols
+Quick asynchronous consultations, most patients approved within 24 hours without video calls
+Flexible dosing: can start at lower doses than standard protocols for sensitive patients

Cons

−Check-ins are patient-initiated rather than scheduled; portal requests are usually answered within 24 hours, but you drive the cadence
−No insurance billing, and customer support runs business days only, no weekends

Our Verdict

Direct Meds GLP-1 edges out Enhance MD with a score of 7.9/10 vs 7.8/10. Published pricing is not a like-for-like monthly comparison: Direct Meds GLP-1 is from $297/mo; Enhance MD is from $212/mo. Enhance MD offers both brand-name and compounded medications, giving you more flexibility.