#surmount-5

1 article tagged #surmount-5.

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Editorial still-life illustrating a comparison of Wegovy and Zepbound for weight loss

Analysis ComparisonsJuly 7, 2026• 14 min read

Wegovy vs Zepbound (June 2026): SURMOUNT-5 Head-to-Head, Wegovy HD, & Cost Comparison

Updated August 2026: SURMOUNT-5 head-to-head trial (NEJM): Zepbound 20.2% vs Wegovy 13.7% weight loss at 72 weeks. Wegovy HD (7.2mg, FDA-approved March 2026) closes the gap at 20.7%. NovoCare lists the Wegovy pen at $199/mo for the first two low-dose fills, then $349/mo at standard strengths ($399 for HD) and pill from $149/mo, prescription required and dose-dependent; LillyDirect lists Zepbound from $299/mo with higher-dose pricing. Both may be as low as $25/mo for eligible commercially insured patients using a savings card.

#surmount-5

Wegovy vs Zepbound (June 2026): SURMOUNT-5 Head-to-Head, Wegovy HD, & Cost Comparison

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Yucca Health