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Zepbound Side Effects (2026): Nausea 29%, Diarrhea 23%, Vomiting 13% — Full Guide with SURMOUNT Trial Data
GuideSide Effects & SafetyApril 20, 2026• 10 min read

Zepbound Side Effects (2026): Nausea 29%, Diarrhea 23%, Vomiting 13% — Full Guide with SURMOUNT Trial Data

Verified April 2026: Zepbound (tirzepatide) side effects from the SURMOUNT clinical trials — nausea affects 24-29% of patients (vs 8% placebo), diarrhea 19-23%, vomiting 8-13%. Only 4.3% discontinued at the highest dose. GI symptoms peak during dose escalation and resolve within 4-8 weeks for most patients. Full breakdown by dose, timeline, management strategies, and when to call your doctor.

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