Direct Meds GLP-1 vs Willow: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

52 providers verified independently·Independent research·How we rank →

Direct Meds GLP-1 beats Willow overall, scoring 7.9/10 vs 7.5/10. Direct Meds GLP-1 is more affordable at $297/mo vs $299/mo. Choose Direct Meds GLP-1 for users wanting simple, all-inclusive pricing without insuranc. Choose Willow for users who want comprehensive clinical support with flexibili.

A side-by-side look at Direct Meds GLP-1 and Willow to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Higher Rated

Direct Meds GLP-1

#10 of 52

7.9/10

Straightforward compounded GLP-1 program with transparent all-inclusive pricing and no hidden fees.

Visit Direct Meds GLP-1

Willow

#24 of 52

7.5/10

Personalized GLP-1 weight loss with ongoing clinical support. Compounded semaglutide and tirzepatide only, Willow explicitly does not prescribe brand-name Wegovy or Zepbound. Added oral compounded semaglutide tablets as a non-injectable option.

Visit Willow

Feature	Direct Meds GLP-1	Willow
Our Score	7.9/10	7.5/10
Starting Price	$297/mo	$299/mo
Medication Type	Compounded	Compounded
Insurance Accepted	No	No
Best For	Users wanting simple, all-inclusive pricing without insurance	Users who want comprehensive clinical support with flexibility between injectable and oral compounded semaglutide routes
Ranking	#10	#24
Get started	Visit Direct Meds GLP-1	Visit Willow

Pros & Cons Compared

Direct Meds GLP-1

Pros

+True all-inclusive pricing, $280/mo covers medication, consultations, shipping, and pharmacy fees with no add-ons
+Clear dose-based pricing published on their site, no surprise cost increases when titrating up
+Fast pharmacy fulfillment: most orders ship within 48 hours of provider approval
+Responsive customer support with live chat available during business hours

Cons

−Compounded medications only, no brand-name Wegovy, Zepbound, or Ozempic on the menu
−The $280/mo flat rate sits above Henry Meds ($199) and TrimRx ($149); Direct Meds' own sublingual drops at $179 are the budget path if the premium stings

Willow

Pros

+Includes monthly provider check-ins and dose adjustments at no extra cost
+Offers both injectable AND oral compounded semaglutide, one of few platforms with a daily oral tablet option
+$299/mo all-in for compounded semaglutide with monthly provider support
+90%+ patient retention rate after 3 months per their published outcomes data

Cons

−Compounded-only, no brand-name Wegovy or Zepbound through the platform
−Tirzepatide pricing reaches $499-$524 at higher doses, starting dose is $399/mo
−Cash-pay only, no insurance billing, though they provide superbills for FSA/HSA
−Founded in 2024, less track record than Ro or Hims, though growth has been fast

Our Verdict

Direct Meds GLP-1 edges out Willow with a score of 7.9/10 vs 7.5/10. If budget is your priority, Direct Meds GLP-1 starts at $297/mo compared to Willow's $299/mo. Choose Direct Meds GLP-1 if you want: users wanting simple, all-inclusive pricing without insurance. Choose Willow if you want: users who want comprehensive clinical support with flexibility between injectable and oral compounded semaglutide routes.

Still undecided? Editor's Featured Pick

Yucca Health

$146/mo · 7.7/10 · Compounded

If neither Direct Meds GLP-1 nor Willow feels like the right fit, our featured pick across all 52 GLP-1 telehealth providers is Yucca Health. It is not the highest-scored provider in our full rankings. We feature it for its low-friction value: a flat $146/mo that stays the same at every dose.

Visit Yucca Health→Read our full Yucca Health review