Direct Meds GLP-1 vs Willow: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

48 providers verified independently·Independent research·How we rank →

Willow beats Direct Meds GLP-1 overall, scoring 8.2/10 vs 7.9/10. Direct Meds GLP-1 is more affordable at $297/mo vs $299/mo. Choose Direct Meds GLP-1 for users wanting simple, all-inclusive pricing without insuranc. Choose Willow for users who want comprehensive clinical support with flexibili.

A side-by-side comparison of Direct Meds GLP-1 and Willow covering pricing, scores, medication types, insurance, and more to help you decide.

Direct Meds GLP-1

#13 of 48

7.9/10

Straightforward compounded GLP-1 program with transparent all-inclusive pricing and no hidden fees.

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Higher Rated

Willow

#8 of 48

8.2/10

Personalized GLP-1 weight loss with ongoing clinical support. Compounded semaglutide and tirzepatide only — Willow explicitly does not prescribe brand-name Wegovy or Zepbound. Added oral compounded semaglutide tablets as a non-injectable option.

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Feature	Direct Meds GLP-1	Willow
Our Score	7.9/10	8.2/10
Starting Price	$297/mo	$299/mo
Medication Type	Compounded	Compounded
Insurance Accepted	No	No
Best For	Users wanting simple, all-inclusive pricing without insurance	Users who want comprehensive clinical support with flexibility between injectable and oral compounded semaglutide routes
Ranking	#13	#8

Pros & Cons Compared

Direct Meds GLP-1

Pros

+True all-inclusive pricing — $280/mo covers medication, consultations, shipping, and pharmacy fees with no add-ons
+Clear dose-based pricing published on their site — no surprise cost increases when titrating up
+Fast pharmacy fulfillment: most orders ship within 48 hours of provider approval
+Responsive customer support with live chat available during business hours

Cons

−Compounded medications only — cannot prescribe brand-name Wegovy, Zepbound, or Ozempic
−At $280/mo for compounded-only, it's pricier than competitors like Henry Meds ($199) or TrimRx ($179)

Willow

Pros

+Includes monthly provider check-ins and dose adjustments at no extra cost
+Offers both injectable AND oral compounded semaglutide — one of few platforms with a daily oral tablet option
+$299/mo all-in for compounded semaglutide with monthly provider support
+90%+ patient retention rate after 3 months per their published outcomes data

Cons

−Compounded-only — no brand-name Wegovy or Zepbound through the platform
−Tirzepatide pricing reaches $499-$524 at higher doses — starting dose is $399/mo
−Cash-pay only — no insurance billing, though they provide superbills for FSA/HSA
−Founded in 2024 — less track record than Ro or Hims, though growth has been fast

Our Verdict

Willow edges out Direct Meds GLP-1 with a score of 8.2/10 vs 7.9/10. If budget is your priority, Direct Meds GLP-1 starts at $297/mo compared to Willow's $299/mo. Choose Direct Meds GLP-1 if you want: users wanting simple, all-inclusive pricing without insurance. Choose Willow if you want: users who want comprehensive clinical support with flexibility between injectable and oral compounded semaglutide routes.

Still undecided? Editor's #1 Overall Pick

Eden Health GLP-1

$249/mo · 8.9/10 · Both

If neither Direct Meds GLP-1 nor Willow feels like the right fit, our overall #1 pick across all 48 GLP-1 telehealth providers is Eden Health GLP-1 — strongest balance of clinical oversight, transparent pricing, and verified availability.

Visit Eden Health GLP-1→Read our full Eden Health GLP-1 review