$212/4 weeks equivalent at Enhance MD
48-week prepay · checked Aug 28
Check price for Enhance MDOn Enhance MD's site · partner link
Comparison · updated October 16, 2026
Enhance MD vs SynergyRx: Enhance MD for compounded medication only, SynergyRx for brand-name or compounded options
Enhance MD and SynergyRx differ in what you pay and which medicines they list. Compounded medicines are not FDA-approved.
These two prices are different kinds of bill, so read the line under each price before you compare them.
Enhance MD pays us a commission when you join through our links. SynergyRx does not. That never changes a score, an order or a fact on this page. How we make money
Which should you choose, Enhance MD or SynergyRx?
Short answer: Choose SynergyRx if you want brand-name medicine as an option. If that doesn't matter to you, compare their plans below.
Enhance MD is best for
Cash-pay shoppers who want the monthly price to stay flat as the dose goes up, and who will do a lab draw and a video visit to get it.
Choose SynergyRx if
- you want brand-name medicine as an option
- you want a pill or another option without needles
The available assessments do not establish a score winner, so choose by the medicine, total cost and care you need.
By Iacob Pastina, Independent Researcher & Publisher
Reviewed & updated · Cites primary sources (FDA, NEJM, CMS) · Not medical advice
Enhance MD vs SynergyRx side by side
| Enhance MD | SynergyRx | |
|---|---|---|
| Price | $212/4 weeks equivalentPrepaid 48-week plan; confirm the full upfront charge | from $199/mo |
| Medicine | Compounded only | Brand-name and compounded |
| Needle-free option | Not listed | Yes, a pill or other oral form |
| Insurance | BothNo insurance listed | |
| Consultation | BothIncluded | |
| Shipping | Free | Free expedited |
| Where it ships | 40 states plus DC: AK, AZ, CA, CO, CT, DC, DE, FL, IA, ID, IL, IN, KS, KY, MA, MD, ME, MI, MN, MT, NC, NE, NH, NJ, NM, NV, NY, OH, OK, OR, PA, RI, SD, TX, UT, VA, VT, WA, WI, WV, WY | Availability depends on the patient's state, the service and clinician eligibility under the terms reviewed October 8, 2026; no all-state GLP-1 service list was verified |
| Trustpilot | 4.0 / 5 across 162 reviews | Not tracked |
| BBB rating | A+ (not accredited) | Not tracked |
| Our score | 9.4/10 Excellent | 6.2/10 Fair |
| Assessment limits | Checked Oct 16, 2026; some details not published. | Checked Oct 16, 2026; few independent reviews yet. |
What Enhance MD and SynergyRx plans cost
Enhance MD
A compounded GLP-1 program with published lab work and a scheduled video visit before prescribing. Core and Advanced are separate molecule options; Elite combines semaglutide and tirzepatide in one formulation. Four-week billing and prepaid 12-, 24- and 48-week plans are not calendar-month or calendar-year prices.
- Microdose Tirzepatide$169/4 weeks1 mg a week of compounded tirzepatide, capped rather than increased. $169 per four-week equivalent on the 12-month plan billed every 48 weeks, $179 on the 6-month plan billed every 24 weeks and $189 on the 3-month plan billed every 12 weeks. Medication ships every 12 weeks. The page showed no price for the 1-month option.
- Compounded Semaglutide (12-month plan)$212/4 weeksAdvertised four-week equivalent; prepaid every 48 weeks, not a calendar year
- Compounded Semaglutide (6-month plan)$224/4 weeksAdvertised four-week equivalent; prepaid every 24 weeks, not calendar months
All 11 Enhance MD plans
- Compounded Semaglutide (3-month plan)$237/4 weeksAdvertised four-week equivalent; prepaid every 12 weeks, not calendar months
- Compounded Semaglutide (month-to-month)$249/4 weeksBilled every 4 weeks
- Compounded Tirzepatide (12-month)$280/4 weeks$280 advertised four-week-equivalent rate on the 12-month plan, billed every 48 weeks; confirm the full upfront total before paying.
- Compounded Tirzepatide (6-month)$296/4 weeks$296 advertised four-week-equivalent rate on the 6-month plan, billed every 24 weeks; confirm the full upfront total before paying.
- Compounded Tirzepatide (3-month)$313/4 weeks$313 advertised four-week-equivalent rate on the 3-month plan, billed every 12 weeks; confirm the full upfront total before paying.
- Compounded Tirzepatide (month-to-month)$329/4 weeks$329 billed every 4 weeks on the shortest plan, before any eligible first-order discount.
- Elite Bundle (sema + tirz)$322A compounded formulation containing semaglutide and tirzepatide together; historical $189 introductory price requires confirmation of the current plan and charge
- NAD+ Therapy (subcutaneous)$169NAD+ injection therapy, separate product line, not a GLP-1
How Enhance MD bills
$212 advertised four-week equivalent on the prepaid 48-week plan, not a calendar-year subscription; shortest plan is $249 billed every 4 weeks
We checked Enhance MD's prices on August 28, 2026.
SynergyRx
Offers oral dissolving tablets for semaglutide and tirzepatide alongside injectable options. Discuss the specific formulation and its supporting evidence with your prescriber rather than assuming the same results across routes.
- Compounded Semaglutide (injection)$199Injectable format, listed as starting at $199 on the products page
- Compounded Semaglutide (oral dissolving tablet)$299Needle-free tablet, listed as starting at $299 on the products page
- Compounded Tirzepatide (injection)$349Injectable format, listed as starting at $349 on the products page
All 6 SynergyRx plans
- Compounded Tirzepatide (oral dissolving tablet)$399Needle-free tablet, listed as starting at $399 on the products page
- Brand-Name Ozempic$499FDA-approved Ozempic with clinical support
- Brand-Name Wegovy/Mounjaro$947FDA-approved brand-name with full clinical support
How SynergyRx bills
The $199 is the lowest compounded semaglutide injection price on its products page; the oral dissolving tablet is $299. A $100 welcome credit is advertised as applied at checkout with no code needed
We checked SynergyRx's prices on September 3, 2026.
What to watch for with Enhance MD and SynergyRx
Enhance MD
- The $212 headline is a four-week equivalent on a prepaid 48-week plan, not a calendar-year price. The shortest plan costs $249 every four weeks on the GLP-1 Core pricing page (verified 2026-09-03)
- Compounded only. Every GLP-1 product page states the formulation is not FDA-approved and is compounded under federal Section 503A guidelines, and no brand-name product is sold
Enhance MD's strengths, cautions and terms
Strengths
- Same price at every dose, so titrating up does not raise the monthly bill. GLP-1 Core is $212 per four-week equivalent on the prepaid 48-week plan and $249 every four weeks on the shortest plan (verified 2026-09-03)
- The monthly price covers lab work, the video visit with a provider, medication from a partner pharmacy and 2-day shipping, with no separate consultation fee
- Support is staffed seven days a week, Monday to Friday 8:00 AM to 8:00 PM EDT and Saturday to Sunday 9:00 AM to 5:00 PM EDT, by phone and email
- Four compounded GLP-1 options including a capped 1 mg microdosing tirzepatide plan from $169 per four weeks on the 48-week plan, plus a full refund of the initial payment if a provider finds you ineligible during onboarding
More to watch for
- Not nationwide. The FAQ lists 40 states plus DC and leaves out Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, North Dakota, South Carolina and Tennessee
- Cash pay with no same-day start: a Quest Diagnostics blood draw and a scheduled video visit both come before a prescription, and no insurance option is shown on the site's pricing, FAQ or terms pages (rendered check 2026-09-03)
- Medicines listed
- Semaglutide (compounded, sold as GLP-1 Core)
- Tirzepatide (compounded, sold as GLP-1 Advanced)
- Semaglutide and tirzepatide in one formulation (compounded, sold as GLP-1 Elite)
- Tirzepatide, 1mg microdosing plan (compounded)
- NAD+ injections (separate anti-aging product, not a GLP-1)
- NAD+ wafers (separate anti-aging product, not a GLP-1)
- Insurance
- No insurance support listed
- Consultation
- Included
- Shipping
- Free
- States
- 40 states plus DC: AK, AZ, CA, CO, CT, DC, DE, FL, IA, ID, IL, IN, KS, KY, MA, MD, ME, MI, MN, MT, NC, NE, NH, NJ, NM, NV, NY, OH, OK, OR, PA, RI, SD, TX, UT, VA, VT, WA, WI, WV, WY. Not available in AL, AR, GA, HI, LA, MO, MS, ND, SC, TN. The FAQ says the company is licensed in all 50 states but that it is launching in the listed states only (verified 2026-09-03)
- Cancellation
- The FAQ says you can pause or cancel your subscription at any time by contacting support, and that membership otherwise renews every 28 days. The 3, 6 and 12-month plans bill every 12, 24 and 48 weeks rather than monthly. Prescription products cannot be returned, and the only refund promised is 100% of the initial payment if a provider finds you ineligible during onboarding (verified 2026-09-03)
SynergyRx
- The terms publish a Casper, WY address. The October 8, 2026 source check did not confirm a Trustpilot profile on its exact domain; that does not establish that no profile or reviews exist.
- Historical brand-name prices were $499-947/mo. Compare the same medication, dose, eligibility and complete charge with the relevant manufacturer's program; a compounded tablet is not an FDA-approved brand equivalent.
SynergyRx's strengths, cautions and terms
Strengths
- Oral dissolving tablets for BOTH semaglutide AND tirzepatide, one of the few platforms with needle-free tirzepatide
- Free expedited shipping included with all orders
- 24/7 support with unlimited messaging, no per-visit fees for follow-up questions or dose adjustments
- Both compounded and brand-name options available (Ozempic, Wegovy, Mounjaro)
More to watch for
- Founding date and ownership are not shown on the site's contact, about, terms or FAQ pages (rendered check 2026-09-03); the terms disclose only a Delaware corporation. The terms also name Usable Health, PC as the medical group while the FAQ names Lion MD.
- Medicines listed
- Semaglutide (compounded, injectable and oral dissolving tablet)
- Tirzepatide (compounded, injectable and oral dissolving tablet)
- Ozempic (brand-name)
- Wegovy (brand-name)
- Mounjaro (brand-name)
- Insurance
- No insurance support listed
- Consultation
- Included
- Shipping
- Free expedited
- States
- Availability depends on the patient's state, the service and clinician eligibility under the terms reviewed October 8, 2026; no all-state GLP-1 service list was verified. Confirm your state before paying.
- Cancellation
- All sales final. The terms say medical consult fees are not eligible for a refund and prescription products cannot be returned, and no cancellation or auto-renewal clause appears in them, yet the about page still shows a Money Back Guarantee badge with no terms attached.
Compounded medicines are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality before they are sold. Read the FDA's explanation of the risks.
Enhance MD vs SynergyRx: common questions
Is Enhance MD or SynergyRx cheaper?
At least one headline price is a starting, introductory, prepaid or partial figure, so neither is simply cheaper.
- Enhance MD$212/4 weeks equivalentprepaid 48-week plan; confirm the full upfront charge
- SynergyRxfrom $199/mostarting price
Which is better, Enhance MD or SynergyRx?
Neither wins outright on our scores, so the better one is the one that fits your medicine, budget and care needs.
Enhance MD lists compounded medication only, and SynergyRx lists brand-name and compounded medication.
Do Enhance MD and SynergyRx offer brand-name medication?
Enhance MD lists compounded medication only, and SynergyRx lists brand-name and compounded medication.
Compounded medications are not FDA-approved. Your prescriber decides which medicine suits you.
Do Enhance MD and SynergyRx take insurance?
Neither Enhance MD nor SynergyRx lists insurance support.
Where these facts come from
Enhance MD:prices checked August 28, 2026, score evidence assessed October 16, 2026.Read our Enhance MD review
SynergyRx:prices checked September 3, 2026, score evidence assessed October 16, 2026.SynergyRx pricing and sources
We score on a published methodology, and partnership never changes a score or a fact here.
What should you compare next?
- Compare semaglutide providers and pricesMove from this head-to-head to the broader semaglutide market without confusing compounded products with FDA-approved brands.
- Compare tirzepatide providers and pricesReview provider options, price units and treatment context across the wider tirzepatide market.
Both Enhance MD and SynergyRx start above the cheapest complete recurring program we track. Across all 38 providers in our index, the lowest price that includes the medicine, consultation and shipping is Eden Health GLP-1 at $99/mo, checked August 28, 2026. This is a price fact, not a treatment recommendation. Compare every program by its complete price
Before you sign up, read our trust check: is Enhance MD legit.
Enhance MD reviewSynergyRx prices and sourcesAll comparisonsFind your match