Enhance MD vs SynergyRx: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher & Publisher

Reviewed & updated August 14, 2026 · Cites primary sources (FDA, NEJM, CMS) · Not medical advice

54 providers verified independently·Independent research·How we rank →

Short answer: Enhance MD scores higher on our rubric, 7.8/10 against 7.6/10. Full reasoning, pricing and the cases where the other one wins are below.

Visit Enhance MD - our pick of these two →or find your match

Enhance MD beats SynergyRx overall, scoring 7.8/10 vs 7.6/10. Published pricing is not a like-for-like monthly comparison: Enhance MD is from $212/mo; SynergyRx is from $199/mo. Choose Enhance MD for budget-conscious users interested in combination therapies. Choose SynergyRx for needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included.

A side-by-side look at Enhance MD and SynergyRx to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Higher Rated

Enhance MD

#13 of 54

7.8/10

Affordable telehealth provider offering both compounded and brand-name GLP-1 medications with combination therapy options.

Visit Enhance MD

SynergyRx

#18 of 54

7.6/10

Bundled GLP-1 program with predictable pricing and round-the-clock support access for peace of mind.

Visit SynergyRx

Feature	Enhance MD	SynergyRx
Why each one	The most affordable platform offering both medication types plus unique combination therapies (GLP-1 + B12, GLP-1 + NAD+) that no other major provider offers at this price.	Oral dissolving tablets for BOTH semaglutide AND tirzepatide, serving needle-phobic patients who want injectable-level results without injections.
Our Score	7.8/10	7.6/10
Headline Price	from $212/mo	from $199/mo
Medication Type	Both	Both
Insurance Accepted	No	No
Best For	Budget-conscious users interested in combination therapies	Needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included
Watch out for	Check-ins are patient-initiated rather than scheduled; portal requests are usually answered within 24 hours, but you drive the cadence	Registered at a Casper, WY address with limited independent reviews. Verify pharmacy partners and provider credentials before enrolling.
Ranking	#13	#18
Get started	Visit Enhance MD	Visit SynergyRx

Pros & Cons Compared

Enhance MD

Pros

+GLP-1 from $49 your first month, then $212/mo, with access to both brand-name and compounded; wafers as low as $84/mo on the 6-month plan
+Offers combination therapies (GLP-1 + B12, GLP-1 + NAD+) for patients wanting enhanced protocols
+Quick asynchronous consultations, most patients approved within 24 hours without video calls
+Flexible dosing: can start at lower doses than standard protocols for sensitive patients

Cons

−Check-ins are patient-initiated rather than scheduled; portal requests are usually answered within 24 hours, but you drive the cadence
−No insurance billing, and customer support runs business days only, no weekends

SynergyRx

Pros

+Oral dissolving tablets for BOTH semaglutide AND tirzepatide, one of the few platforms with needle-free tirzepatide
+Free expedited shipping included with all orders
+24/7 support with unlimited messaging, no per-visit fees for follow-up questions or dose adjustments
+Both compounded and brand-name options available (Ozempic, Wegovy, Mounjaro)

Cons

−Registered at a Casper, WY address with limited independent reviews. Verify pharmacy partners and provider credentials before enrolling.
−Brand-name pricing ($499-947/mo) is very high compared to direct manufacturer programs like LillyDirect. Use SynergyRx for its compounded oral tablets; source brand-name directly if that's what you need.
−Company history, founding date, and ownership structure are not publicly disclosed. Ask support for pharmacy and prescriber details upfront.

Our Verdict

Enhance MD edges out SynergyRx with a score of 7.8/10 vs 7.6/10. Published pricing is not a like-for-like monthly comparison: Enhance MD is from $212/mo; SynergyRx is from $199/mo.