Fridays vs SynergyRx: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

52 providers verified independently·Independent research·How we rank →

Fridays beats SynergyRx overall, scoring 8.7/10 vs 7.6/10. SynergyRx is more affordable at $199/mo vs $249/mo. Choose Fridays for users who want a holistic program with coaching, nutrition s. Choose SynergyRx for needle-phobic users who want oral dissolving tablets for sem.

A side-by-side look at Fridays and SynergyRx to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Higher Rated

Fridays

#2 of 52

8.7/10

Holistic weight loss program combining GLP-1 medications with lifestyle coaching, nutrition guidance, and ongoing support.

Visit Fridays

SynergyRx

#22 of 52

7.6/10

Bundled GLP-1 program with predictable pricing and round-the-clock support access for peace of mind.

Visit SynergyRx

Feature	Fridays	SynergyRx
Our Score	8.7/10	7.6/10
Starting Price	$249/mo	$199/mo
Medication Type	Both	Both
Insurance Accepted	Yes	No
Best For	Users who want a holistic program with coaching, nutrition support, and flexible pricing	Needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included
Ranking	#2	#22
Get started	Visit Fridays	Visit SynergyRx

Pros & Cons Compared

Fridays

Pros

+One of the few platforms that bills insurance directly, can reduce out-of-pocket to $25-50/mo with coverage
+Includes 1-on-1 nutrition coaching and weekly check-ins, not just medication prescriptions
+Offers brand-name Wegovy/Zepbound and compounded options, switches based on insurance formulary
+Flexible plans: medication-only ($249/mo) or full coaching program ($299/mo)

Cons

−The coaching-heavy model adds complexity, three different plan tiers with different inclusions
−Without insurance, $249/mo for medication-only is above average for what you get clinically

SynergyRx

Pros

+Oral dissolving tablets for BOTH semaglutide AND tirzepatide, one of the few platforms with needle-free tirzepatide
+Free expedited shipping included with all orders
+24/7 support with unlimited messaging, no per-visit fees for follow-up questions or dose adjustments
+Both compounded and brand-name options available (Ozempic, Wegovy, Mounjaro)

Cons

−Registered at a Casper, WY address with limited independent reviews. Verify pharmacy partners and provider credentials before enrolling.
−Brand-name pricing ($499-947/mo) is very high compared to direct manufacturer programs like LillyDirect. Use SynergyRx for its compounded oral tablets; source brand-name directly if that's what you need.
−Company history, founding date, and ownership structure are not publicly disclosed. Ask support for pharmacy and prescriber details upfront.

Our Verdict

Fridays edges out SynergyRx with a score of 8.7/10 vs 7.6/10. If budget is your priority, SynergyRx starts at $199/mo compared to Fridays's $249/mo. Fridays accepts insurance, which can significantly reduce your out-of-pocket costs. Choose Fridays if you want: users who want a holistic program with coaching, nutrition support, and flexible pricing. Choose SynergyRx if you want: needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included.

Still undecided? Editor's Featured Pick

Yucca Health

$146/mo · 7.7/10 · Compounded

If neither Fridays nor SynergyRx feels like the right fit, our featured pick across all 52 GLP-1 telehealth providers is Yucca Health. It is not the highest-scored provider in our full rankings. We feature it for its low-friction value: a flat $146/mo that stays the same at every dose.

Visit Yucca Health→Read our full Yucca Health review