Sesame Care vs SynergyRx: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher & Publisher

Reviewed & updated August 14, 2026 · Cites primary sources (FDA, NEJM, CMS) · Not medical advice

54 providers verified independently·Independent research·How we rank →

Short answer: Sesame Care scores higher on our rubric, 7.9/10 against 7.6/10. Full reasoning, pricing and the cases where the other one wins are below.

Visit Sesame Care - our pick of these two →or find your match

Sesame Care beats SynergyRx overall, scoring 7.9/10 vs 7.6/10. Published pricing is not a like-for-like monthly comparison: Sesame Care is published $99/mo; total not verified; SynergyRx is from $199/mo. Choose Sesame Care for users who want cheap fda-approved brand-name glp-1 access ($149-349/mo wegovy and zepbound via success by sesame), or insured patients who just need a prescriber. Choose SynergyRx for needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included.

A side-by-side look at Sesame Care and SynergyRx to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Higher Rated

Sesame Care

#5 of 54

7.9/10

Telehealth marketplace offering both a low-cost consultation model ($25/visit) and the new Success by Sesame membership program ($59/mo on 3/6/12-month plans), which coordinates access to FDA-approved brand-name GLP-1 medications including Foundayo (orforglipron), Wegovy pen and pill, and Zepbound. Medication is billed separately.

Visit Sesame Care

SynergyRx

#18 of 54

7.6/10

Bundled GLP-1 program with predictable pricing and round-the-clock support access for peace of mind.

Visit SynergyRx

Feature	Sesame Care	SynergyRx
Why each one	The broadest FDA-approved brand-name GLP-1 menu among low-cost telehealth options, Wegovy pen and pill, Zepbound, Ozempic, Mounjaro, Rybelsus, and Foundayo, coordinated through the new Success by Sesame membership at $59/mo plus medication.	Oral dissolving tablets for BOTH semaglutide AND tirzepatide, serving needle-phobic patients who want injectable-level results without injections.
Our Score	7.9/10	7.6/10
Headline Price	published $99/mo; total not verified	from $199/mo
Medication Type	Both	Both
Insurance Accepted	Yes	No
Best For	Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber	Needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included
Watch out for	Two distinct products (pay-per-visit vs the Success membership) sit side by side, so decide which you're buying before checkout	Registered at a Casper, WY address with limited independent reviews. Verify pharmacy partners and provider credentials before enrolling.
Ranking	#5	#18
Get started	Visit Sesame Care	Visit SynergyRx

Pros & Cons Compared

Sesame Care

Pros

+Success by Sesame program launched 2026, $59/mo on a 3/6/12-month plan, includes labs, unlimited messaging, and provider choice; medication is separate
+Brand-name cash pricing is competitive, Wegovy pen $199 intro / $349 ongoing, Zepbound vial $299, Wegovy pill $149
+Foundayo (Lilly's FDA-approved oral GLP-1) available as of April 2026 at $149/mo
+Original pay-per-visit model still available at $25/consultation for users who just need a prescriber

Cons

−Two distinct products (pay-per-visit vs the Success membership) sit side by side, so decide which you're buying before checkout
−The $59/mo Success by Sesame rate requires a 3-month minimum commitment; month-to-month is available at $99/mo if you don't want to commit
−Compounded meds are de-emphasized in the current marketing, the platform now leads with FDA-approved brand-name paths
−A marketplace rather than a concierge, expect less hand-holding than dedicated subscription platforms

SynergyRx

Pros

+Oral dissolving tablets for BOTH semaglutide AND tirzepatide, one of the few platforms with needle-free tirzepatide
+Free expedited shipping included with all orders
+24/7 support with unlimited messaging, no per-visit fees for follow-up questions or dose adjustments
+Both compounded and brand-name options available (Ozempic, Wegovy, Mounjaro)

Cons

−Registered at a Casper, WY address with limited independent reviews. Verify pharmacy partners and provider credentials before enrolling.
−Brand-name pricing ($499-947/mo) is very high compared to direct manufacturer programs like LillyDirect. Use SynergyRx for its compounded oral tablets; source brand-name directly if that's what you need.
−Company history, founding date, and ownership structure are not publicly disclosed. Ask support for pharmacy and prescriber details upfront.

Our Verdict

Sesame Care edges out SynergyRx with a score of 7.9/10 vs 7.6/10. Published pricing is not a like-for-like monthly comparison: Sesame Care is published $99/mo; total not verified; SynergyRx is from $199/mo. Sesame Care accepts insurance, which can significantly reduce your out-of-pocket costs.