Independent provider comparison
Updated September 21, 2026
Sesame Care vs SynergyRx: Which GLP-1 provider is better?
A side-by-side look at total cost, medication format, care, commitment and the situations where each option makes more sense.
The decision
Which should you choose, Sesame Care or SynergyRx?
Short answer: Sesame Care scores higher on our published rubric, 7.9/10 against 7.6/10. Published pricing is not a like-for-like monthly comparison: Sesame Care is published $99/mo; total not verified; SynergyRx is from $199/mo.
Consider Sesame Care if
Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber.
Consider SynergyRx if
Needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included.
Scores follow our published methodology. Partnership status does not change the score or the factual comparison.
Cost
First charge, renewal and commitment
Treatment
Medication, form and approval status
Care
Clinical review and ongoing support
Terms
Cancellation and material cautions
Sesame Care
#3 of 36Best for users who want cheap fda-approved brand-name glp-1 access ($149-349/mo wegovy and zepbound via success by sesame), or insured patients who just need a prescriber.
Visit Sesame Care
SynergyRx
#9 of 36Best for needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included.
View SynergyRx termsSide by side
Sesame Care vs SynergyRx at a glance
Compare the price unit as well as the number. A medication-only price, prepaid monthly equivalent and complete recurring program are not the same thing.
| Feature | Sesame Care | SynergyRx |
|---|---|---|
| Why each one | The broadest FDA-approved brand-name GLP-1 menu among low-cost telehealth options, Wegovy pen and pill, Zepbound, Ozempic, Mounjaro, Rybelsus, and Foundayo, coordinated through the Success by Sesame membership at $59/mo on a 12-month commitment plus medication. | Offers oral dissolving tablets for semaglutide and tirzepatide alongside injectable options. Discuss the specific formulation and its supporting evidence with your prescriber rather than assuming the same results across routes. |
| Our Score | 7.9/10 | 7.6/10 |
| Headline Price | published $99/mo; total not verified | from $199/mo |
| Medication Type | Brand | Both |
| Insurance Accepted | Yes | No |
| Best For | Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber | Needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included |
| Watch out for | Sesame runs three separate routes under one brand: the Success by Sesame weight loss subscription, EverydayRx for diabetes, and one-off visits from $34. Check which one you are signing up for before you pay. | The Casper, WY address in its terms is a suite mailbox rather than a clinic, and the brand has no Trustpilot profile, so there is little independent feedback to weigh against its own testimonials. |
| Ranking | #3 | #9 |
| Get started | Visit Sesame Care | View SynergyRx terms |
Trade-offs
Strengths and cautions compared
Sesame Care
Pros
- +Success by Sesame is $59/mo on the 12-month commitment and includes provider visits, unlimited messaging and provider choice; lab work is covered only at Quest Diagnostics and not in AZ, HI, ND, NJ, NY, OK, RI, SD or WY, where lab fees are extra; medication is separate
- +Brand-name cash pricing is competitive, Wegovy pen $199 intro / $349 ongoing, Zepbound vial $299, Wegovy pill $149
- +Foundayo (Lilly's FDA-approved oral GLP-1) available as of April 2026 at $149/mo
1 more documented strengths
- +The pay-per-visit route is still there, with visits starting at $34, for users who just need a prescriber
Cons
- −Sesame runs three separate routes under one brand: the Success by Sesame weight loss subscription, EverydayRx for diabetes, and one-off visits from $34. Check which one you are signing up for before you pay.
- −The $59/mo Success by Sesame rate applies only on a 12-month commitment. The 3-month plan works out near $79/mo and the 6-month near $69/mo from the savings the FAQ publishes, and the no-commitment plan is $99 billed every 28 days, which is 13 charges a year.
- −There is no compounded option. Sesame states that compounded semaglutide is not currently available through it, so every route here is brand-name and the medication is billed on top of the program fee.
1 more documented cautions
- −A marketplace rather than a concierge, expect less hand-holding than dedicated subscription platforms
SynergyRx
Pros
- +Oral dissolving tablets for BOTH semaglutide AND tirzepatide, one of the few platforms with needle-free tirzepatide
- +Free expedited shipping included with all orders
- +24/7 support with unlimited messaging, no per-visit fees for follow-up questions or dose adjustments
1 more documented strengths
- +Both compounded and brand-name options available (Ozempic, Wegovy, Mounjaro)
Cons
- −The Casper, WY address in its terms is a suite mailbox rather than a clinic, and the brand has no Trustpilot profile, so there is little independent feedback to weigh against its own testimonials.
- −Brand-name pricing ($499-947/mo) is very high compared to direct manufacturer programs like LillyDirect. Use SynergyRx for its compounded oral tablets; source brand-name directly if that's what you need.
- −Founding date and ownership are not shown on the site's contact, about, terms or FAQ pages (rendered check 2026-09-03); the terms disclose only a Delaware corporation. The terms also name Usable Health, PC as the medical group while the FAQ names Lion MD.
Our Verdict
Sesame Care edges out SynergyRx with a score of 7.9/10 vs 7.6/10. Published pricing is not a like-for-like monthly comparison: Sesame Care is published $99/mo; total not verified; SynergyRx is from $199/mo. Sesame Care accepts insurance, which can significantly reduce your out-of-pocket costs. SynergyRx offers both brand-name and compounded medications, giving you more flexibility.
Keep narrowing the decision
What should you compare next?
Use the unresolved part of this choice, not a generic related article. These guides own the broader medication, coverage or complete-cost question.
- Pill decisionCompare Wegovy pill prices and accessUse the dedicated guide for dose-specific costs, required memberships and which providers currently list the FDA-approved pill.Continue
- Coverage decisionCheck your GLP-1 insurance pathLook up plan-specific coverage questions before treating a cash price or an insurance route as your final out-of-pocket cost.Continue
- Cost decisionCompare complete recurring program costsSee which prices include medication, clinical care and shipping, and which headline amounts require another fee or commitment.Continue
Reviews and pricing sources
Related comparisons
More head-to-head comparisons involving Sesame Care and SynergyRx.
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- Compare SynergyRx and Bodybuilding Health+$179/mo month-to-month
Not sure which one is right for you?
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Still working out whether either one is above board? We check that separately: is Sesame Care legit, with the verification evidence behind each answer.
Our pick of these two: Sesame Care · 7.9/10