Sesame Care vs SynergyRx: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

48 providers verified independently·Independent research·How we rank →

Sesame Care beats SynergyRx overall, scoring 7.9/10 vs 7.6/10. Sesame Care is more affordable at $99/mo vs $199/mo. Choose Sesame Care for users who want cheap fda-approved brand-name glp-1 access ($. Choose SynergyRx for users who want predictable bundled pricing with 24/7 support.

A side-by-side comparison of Sesame Care and SynergyRx covering pricing, scores, medication types, insurance, and more to help you decide.

Higher Rated

Sesame Care

#10 of 48

7.9/10

Telehealth marketplace offering both a low-cost consultation model ($25/visit) and the new Success by Sesame membership program ($59/mo on 3/6/12-month plans) that bundles FDA-approved brand-name GLP-1 medications — including Foundayo (orforglipron), Wegovy pen and pill, and Zepbound.

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SynergyRx

#24 of 48

7.6/10

Bundled GLP-1 program with predictable pricing and round-the-clock support access for peace of mind.

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Feature	Sesame Care	SynergyRx
Our Score	7.9/10	7.6/10
Starting Price	$99/mo	$199/mo
Medication Type	Both	Both
Insurance Accepted	Yes	No
Best For	Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber	Users who want predictable bundled pricing with 24/7 support access
Ranking	#10	#24

Pros & Cons Compared

Sesame Care

Pros

+Success by Sesame program launched 2026 — $59/mo on a 3/6/12-month plan, bundles labs, unlimited messaging, and provider choice
+Brand-name cash pricing is competitive — Wegovy pen $199 intro / $349 ongoing, Zepbound vial $299, Wegovy pill $149
+Foundayo (Lilly's FDA-approved oral GLP-1) available as of April 2026 at $149/mo
+Original pay-per-visit model still available at $25/consultation for users who just need a prescriber

Cons

−Membership model adds complexity — two distinct products (pay-per-visit vs Success membership) can be confusing
−Success by Sesame requires a 3-month minimum commitment to hit the $59/mo rate
−Compounded meds are de-emphasized on the current marketing — focus has shifted to FDA-approved brand-name paths
−Less hand-holding than dedicated subscription platforms like Willow or Eden Health

SynergyRx

Pros

+Oral dissolving tablets for BOTH semaglutide AND tirzepatide — one of the few platforms with needle-free tirzepatide
+Free expedited shipping included with all orders
+24/7 support with unlimited messaging — no per-visit fees for follow-up questions or dose adjustments
+Both compounded and brand-name options available (Ozempic, Wegovy, Mounjaro)

Cons

−Casper, WY registration address and limited independent reviews raise legitimacy questions
−Brand-name pricing ($499-947/mo) is very high compared to direct manufacturer programs like LillyDirect
−Company history, founding date, and ownership structure are not publicly disclosed

Our Verdict

Sesame Care edges out SynergyRx with a score of 7.9/10 vs 7.6/10. If budget is your priority, Sesame Care starts at $99/mo compared to SynergyRx's $199/mo. Sesame Care accepts insurance, which can significantly reduce your out-of-pocket costs. Choose Sesame Care if you want: users who want cheap fda-approved brand-name glp-1 access ($149-349/mo wegovy and zepbound via success by sesame), or insured patients who just need a prescriber. Choose SynergyRx if you want: users who want predictable bundled pricing with 24/7 support access.

Still undecided? Editor's #1 Overall Pick

Eden Health GLP-1

$249/mo · 8.9/10 · Both

If neither Sesame Care nor SynergyRx feels like the right fit, our overall #1 pick across all 48 GLP-1 telehealth providers is Eden Health GLP-1 — strongest balance of clinical oversight, transparent pricing, and verified availability.

Visit Eden Health GLP-1→Read our full Eden Health GLP-1 review