Independent provider comparison
Updated October 9, 2026
Sesame Care vs SynergyRx: Costs, care and treatment fit
A side-by-side look at total cost, medication format, care, commitment and the situations where each option makes more sense.
The decision
Which should you choose, Sesame Care or SynergyRx?
Short answer: The available assessments do not establish a score winner. Compare medication, full cost, care and commitment to decide which fits your needs. Published pricing is not a like-for-like monthly comparison: Sesame Care is $99/mo; program fee + medication; confirm monthly vs 28-day billing; SynergyRx is from $199/mo.
Consider Sesame Care if
Users who want provider choice and brand-name GLP-1 options, with medication billed separately and insurance assistance when applicable.
Consider SynergyRx if
Needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included.
Read each assessment label below: missing evidence is not evidence of poor care. Partnership status does not change the score or the factual comparison.
Sesame Care
Legacy assessmentThis score comes from an earlier or incomplete assessment. It does not establish that this program is better or worse than another.
Best for users who want provider choice and brand-name glp-1 options, with medication billed separately and insurance assistance when applicable.
Visit Sesame Care
SynergyRx
Assessment limitedThis published score has not been reconciled with its recorded evidence. A direct numerical comparison may mislead.
Best for needle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included.
View SynergyRx termsSide by side
Sesame Care vs SynergyRx at a glance
Compare the price unit as well as the number. A medication-only price, prepaid monthly equivalent and complete recurring program are not the same thing.
| Feature | Sesame Care | SynergyRx |
|---|---|---|
Why each oneSesame CareProvider choice, ongoing video care and medication prior-authorization help, with a separately priced brand-name GLP-1 menu and $59/mo advertised care on an annual commitment. SynergyRxOffers oral dissolving tablets for semaglutide and tirzepatide alongside injectable options. Discuss the specific formulation and its supporting evidence with your prescriber rather than assuming the same results across routes. | ||
| Published Assessment | 7.9/10 Legacy assessment | 7.6/10 Assessment limited |
Assessment limitsSesame CareThis score comes from an earlier or incomplete assessment. It does not establish that this program is better or worse than another. SynergyRxThis published score has not been reconciled with its recorded evidence. A direct numerical comparison may mislead. | ||
| Headline Price | $99/mo; program fee + medication; confirm monthly vs 28-day billing | from $199/mo |
| Medication Type | Brand | Both |
| Insurance Accepted | Yes | No |
Best ForSesame CareUsers who want provider choice and brand-name GLP-1 options, with medication billed separately and insurance assistance when applicable SynergyRxNeedle-phobic users who want oral dissolving tablets for semaglutide or tirzepatide, with 24/7 support included | ||
Watch out forSesame CareSesame runs three separate routes under one brand: the Success by Sesame weight loss subscription, EverydayRx for diabetes, and one-off visits from $34. Check which one you are signing up for before you pay. SynergyRxThe terms publish a Casper, WY address. The exact-domain Trustpilot profile could not be verified in the October 8, 2026 source check; that does not establish that no profile or reviews exist. | ||
| Get started | Visit Sesame Care | View SynergyRx terms |
Trade-offs
Strengths and cautions compared
Sesame Care
Pros
- +Success by Sesame is $59/mo on the 12-month commitment and includes provider visits, unlimited messaging and provider choice; lab work is covered only at Quest Diagnostics and not in AZ, HI, ND, NJ, NY, OK, RI, SD or WY, where lab fees are extra; medication is separate
- +Published medication-only offers include eligible Wegovy pen starter doses at $199 for two months, then $349; the Wegovy pill and Zepbound KwikPen have dose-specific prices
- +Listed oral brands include Wegovy and Foundayo, with medication starting at $149 for eligible doses; the care fee is separate
1 more documented strengths
- +Provider choice, ongoing video visits, messaging and app tools for weight, dose and side-effect tracking are described in the program
Cons
- −Sesame runs three separate routes under one brand: the Success by Sesame weight loss subscription, EverydayRx for diabetes, and one-off visits from $34. Check which one you are signing up for before you pay.
- −The $59/mo Success by Sesame rate applies only on a 12-month commitment. The 3-month plan works out near $79/mo and the 6-month near $69/mo from the savings the FAQ publishes. For the $99 no-commitment plan, one FAQ says monthly and another says every 28 days. Confirm the interval and number of charges before budgeting for a year.
- −Sesame says compounded semaglutide is not currently available. Its published GLP-1 menu is brand-name; medication is billed on top of the program or visit fee.
1 more documented cautions
- −Providers can set higher fees than the advertised program rate. Confirm the selected clinician's price and support arrangements before enrolling
SynergyRx
Pros
- +Oral dissolving tablets for BOTH semaglutide AND tirzepatide, one of the few platforms with needle-free tirzepatide
- +Free expedited shipping included with all orders
- +24/7 support with unlimited messaging, no per-visit fees for follow-up questions or dose adjustments
1 more documented strengths
- +Both compounded and brand-name options available (Ozempic, Wegovy, Mounjaro)
Cons
- −The terms publish a Casper, WY address. The exact-domain Trustpilot profile could not be verified in the October 8, 2026 source check; that does not establish that no profile or reviews exist.
- −Historical brand-name prices were $499-947/mo. Compare the same medication, dose, eligibility and complete charge with the relevant manufacturer's program; a compounded tablet is not an FDA-approved brand equivalent.
- −Founding date and ownership are not shown on the site's contact, about, terms or FAQ pages (rendered check 2026-09-03); the terms disclose only a Delaware corporation. The terms also name Usable Health, PC as the medical group while the FAQ names Lion MD.
Our Verdict
The available assessments do not establish a score winner between Sesame Care and SynergyRx. Compare the medication, full cost, care and commitment that fit your needs. An incomplete assessment is not evidence of poor care. Published pricing is not a like-for-like monthly comparison: Sesame Care is $99/mo; program fee + medication; confirm monthly vs 28-day billing; SynergyRx is from $199/mo. Sesame Care lists insurance support. Confirm coverage for your exact plan and prescription, including any separate program fees. SynergyRx lists brand-name and compounded options. Check the exact product, availability and payment terms; these are not interchangeable treatments.
Keep narrowing the decision
What should you compare next?
Use the unresolved part of this choice, not a generic related article. These guides own the broader medication, coverage or complete-cost question.
- Pill decisionCompare Wegovy pill prices and accessUse the dedicated guide for dose-specific costs, required memberships and which providers currently list the FDA-approved pill.Continue
- Coverage decisionCheck your GLP-1 insurance pathLook up plan-specific coverage questions before treating a cash price or an insurance route as your final out-of-pocket cost.Continue
- Cost decisionCompare complete recurring program costsSee which prices include medication, clinical care and shipping, and which headline amounts require another fee or commitment.Continue
Try Sesame Care
Headline price: $99/mo; program fee + medication; confirm monthly vs 28-day billing
Visit Sesame CareReviews and pricing sources
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Still working out whether either one is above board? We check that separately: is Sesame Care legit, with the verification evidence behind each answer.