Sesame Care vs TMates: Which GLP-1 Provider Is Better?
By Iacob Pastina, Independent Researcher
Sesame Care beats TMates overall, scoring 7.9/10 vs 7.8/10. Sesame Care is more affordable at $99/mo vs $158/mo. Choose Sesame Care for users who want cheap fda-approved brand-name glp-1 access ($. Choose TMates for users who want commitment-discount pricing on compounded glp.
A side-by-side look at Sesame Care and TMates to help you decide. We compare them on:
- •Starting price per month
- •Our overall score, out of 10
- •Medication type, brand-name or compounded
- •Whether they accept insurance
- •Who each one is best for
Sesame Care
#7 of 52Telehealth marketplace offering both a low-cost consultation model ($25/visit) and the new Success by Sesame membership program ($59/mo on 3/6/12-month plans) that bundles FDA-approved brand-name GLP-1 medications, including Foundayo (orforglipron), Wegovy pen and pill, and Zepbound.
Visit Sesame CareTMates
#14 of 52Telemedicine platform offering two distinct archetypes: compounded semaglutide and tirzepatide with medication included (commitment pricing $158-$249/mo), and a clinical-service-only path to brand-name Wegovy/Zepbound at $99/mo where the prescription is sent to the patient's pharmacy. Phentermine also available. 2026 expansion added brand-name FDA-approved options.
Visit TMates| Feature | Sesame Care | TMates |
|---|---|---|
| Our Score | 7.9/10 | 7.8/10 |
| Starting Price | $99/mo | $158/mo |
| Medication Type | Both | Both |
| Insurance Accepted | Yes | Yes |
| Best For | Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber | Users who want commitment-discount pricing on compounded GLP-1s ($158-$249/mo, medication included) or a $99/mo clinical path to brand Wegovy or Zepbound filled at their own pharmacy |
| Ranking | #7 | #14 |
| Get started | Visit Sesame Care | Visit TMates |
Pros & Cons Compared
Sesame Care
Pros
- +Success by Sesame program launched 2026, $59/mo on a 3/6/12-month plan, bundles labs, unlimited messaging, and provider choice
- +Brand-name cash pricing is competitive, Wegovy pen $199 intro / $349 ongoing, Zepbound vial $299, Wegovy pill $149
- +Foundayo (Lilly's FDA-approved oral GLP-1) available as of April 2026 at $149/mo
- +Original pay-per-visit model still available at $25/consultation for users who just need a prescriber
Cons
- −Two distinct products (pay-per-visit vs the Success membership) sit side by side, so decide which you're buying before checkout
- −The $59/mo Success by Sesame rate requires a 3-month minimum commitment; month-to-month is available at $99/mo if you don't want to commit
- −Compounded meds are de-emphasized in the current marketing, the platform now leads with FDA-approved brand-name paths
- −A marketplace rather than a concierge, expect less hand-holding than dedicated subscription platforms
TMates
Pros
- +Clinical-service-only path to brand Wegovy and Zepbound at $99/mo, prescription goes to patient's pharmacy (you fill separately using insurance or cash)
- +Steep multi-month commitment discounts on compounded sema, $158/mo on 12-month plan ($1,900 upfront) vs $249/mo month-to-month
- +Same price at all dose levels for compounded, no cost escalation as you titrate up
- +Phentermine available at $149/mo for patients who benefit from a different appetite-suppressant approach
Cons
- −The $99/mo Wegovy/Zepbound tier is the clinical service only. Medication is billed separately at your pharmacy (can be $1,000+/mo cash without insurance). Choose this tier when your insurance covers the drug itself.
- −The best compounded rates require prepayment: $1,050 upfront for 6 months, $1,900 for 12. Start at $249 month-to-month if you want to test fit first.
- −The intake is a 90-second quiz. Fast, but lighter screening than competitors with full medical intakes. Better suited to patients who already know GLP-1 basics.
- −TMates prescribes brand-name but does not dispense it, and is not affiliated with Novo Nordisk (Wegovy) or Eli Lilly (Zepbound). Your own pharmacy fills the Rx.
Our Verdict
Sesame Care edges out TMates with a score of 7.9/10 vs 7.8/10. If budget is your priority, Sesame Care starts at $99/mo compared to TMates's $158/mo. Choose Sesame Care if you want: users who want cheap fda-approved brand-name glp-1 access ($149-349/mo wegovy and zepbound via success by sesame), or insured patients who just need a prescriber. Choose TMates if you want: users who want commitment-discount pricing on compounded glp-1s ($158-$249/mo, medication included) or a $99/mo clinical path to brand wegovy or zepbound filled at their own pharmacy.
Still undecided? Editor's Featured Pick
Yucca Health
$146/mo · 7.7/10 · Compounded
If neither Sesame Care nor TMates feels like the right fit, our featured pick across all 52 GLP-1 telehealth providers is Yucca Health. It is not the highest-scored provider in our full rankings. We feature it for its low-friction value: a flat $146/mo that stays the same at every dose.
Read Full Reviews
Related comparisons
Other matchups readers comparing Sesame Care or TMates tend to look at next.
- Sesame Care vs Found$129/mo
- Sesame Care vs Hers$199/mo
- Sesame Care vs bmiMD$119/mo
- TMates vs Shed$199/mo
- TMates vs Henry Meds$199/mo
- TMates vs Sprout Health$199/mo
Not sure which one is right for you?
Answer a few quick questions and we'll match you to the best GLP-1 provider for your needs. Or keep exploring below.