Independent provider comparison
Updated September 21, 2026
Sesame Care vs TMates: Which GLP-1 provider is better?
A side-by-side look at total cost, medication format, care, commitment and the situations where each option makes more sense.
The decision
Which should you choose, Sesame Care or TMates?
Short answer: Sesame Care scores higher on our published rubric, 7.9/10 against 7.8/10. Published pricing is not a like-for-like monthly comparison: Sesame Care is published $99/mo; total not verified; TMates is from $158/mo.
Consider Sesame Care if
Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber.
Consider TMates if
Users who want commitment-discount pricing on compounded GLP-1s (semaglutide $158-$249/mo, tirzepatide $167-$297/mo, medication included) or a $99/mo clinical path to brand Wegovy or Zepbound filled at their own pharmacy.
Scores follow our published methodology. Partnership status does not change the score or the factual comparison.
Cost
First charge, renewal and commitment
Treatment
Medication, form and approval status
Care
Clinical review and ongoing support
Terms
Cancellation and material cautions
Sesame Care
#3 of 36Best for users who want cheap fda-approved brand-name glp-1 access ($149-349/mo wegovy and zepbound via success by sesame), or insured patients who just need a prescriber.
Visit Sesame Care
TMates
#6 of 36Best for users who want commitment-discount pricing on compounded glp-1s (semaglutide $158-$249/mo, tirzepatide $167-$297/mo, medication included) or a $99/mo clinical path to brand wegovy or zepbound filled at their own pharmacy.
Visit TMatesSide by side
Sesame Care vs TMates at a glance
Compare the price unit as well as the number. A medication-only price, prepaid monthly equivalent and complete recurring program are not the same thing.
| Feature | Sesame Care | TMates |
|---|---|---|
| Why each one | The broadest FDA-approved brand-name GLP-1 menu among low-cost telehealth options, Wegovy pen and pill, Zepbound, Ozempic, Mounjaro, Rybelsus, and Foundayo, coordinated through the Success by Sesame membership at $59/mo on a 12-month commitment plus medication. | Two-archetype platform: (1) compounded GLP-1s with medication included and steep multi-month commitment discounts; (2) cheap $99/mo clinical service for brand Wegovy/Zepbound where you fill the prescription at your own pharmacy. |
| Our Score | 7.9/10 | 7.8/10 |
| Headline Price | published $99/mo; total not verified | from $158/mo |
| Medication Type | Brand | Both |
| Insurance Accepted | Yes | Yes |
| Best For | Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber | Users who want commitment-discount pricing on compounded GLP-1s (semaglutide $158-$249/mo, tirzepatide $167-$297/mo, medication included) or a $99/mo clinical path to brand Wegovy or Zepbound filled at their own pharmacy |
| Watch out for | Sesame runs three separate routes under one brand: the Success by Sesame weight loss subscription, EverydayRx for diabetes, and one-off visits from $34. Check which one you are signing up for before you pay. | The $99/mo Wegovy or Zepbound tier buys the prescription and provider oversight only. TMates says it does not dispense or ship the drug, and no price for the medication itself appears on its product or category pages, so your own pharmacy bills you separately (checked 2026-09-03). |
| Ranking | #3 | #6 |
| Get started | Visit Sesame Care | Visit TMates |
Trade-offs
Strengths and cautions compared
Sesame Care
Pros
- +Success by Sesame is $59/mo on the 12-month commitment and includes provider visits, unlimited messaging and provider choice; lab work is covered only at Quest Diagnostics and not in AZ, HI, ND, NJ, NY, OK, RI, SD or WY, where lab fees are extra; medication is separate
- +Brand-name cash pricing is competitive, Wegovy pen $199 intro / $349 ongoing, Zepbound vial $299, Wegovy pill $149
- +Foundayo (Lilly's FDA-approved oral GLP-1) available as of April 2026 at $149/mo
1 more documented strengths
- +The pay-per-visit route is still there, with visits starting at $34, for users who just need a prescriber
Cons
- −Sesame runs three separate routes under one brand: the Success by Sesame weight loss subscription, EverydayRx for diabetes, and one-off visits from $34. Check which one you are signing up for before you pay.
- −The $59/mo Success by Sesame rate applies only on a 12-month commitment. The 3-month plan works out near $79/mo and the 6-month near $69/mo from the savings the FAQ publishes, and the no-commitment plan is $99 billed every 28 days, which is 13 charges a year.
- −There is no compounded option. Sesame states that compounded semaglutide is not currently available through it, so every route here is brand-name and the medication is billed on top of the program fee.
1 more documented cautions
- −A marketplace rather than a concierge, expect less hand-holding than dedicated subscription platforms
TMates
Pros
- +Clinical-service-only path to brand Wegovy and Zepbound at $99/mo, prescription goes to patient's pharmacy (you fill separately using insurance or cash)
- +Steep multi-month commitment discounts on compounded sema, $158/mo on 12-month plan ($1,900 upfront) vs $249/mo month-to-month
- +Same price at all dose levels for compounded, no cost escalation as you titrate up
1 more documented strengths
- +Phentermine available at $149/mo for patients who benefit from a different appetite-suppressant approach
Cons
- −The $99/mo Wegovy or Zepbound tier buys the prescription and provider oversight only. TMates says it does not dispense or ship the drug, and no price for the medication itself appears on its product or category pages, so your own pharmacy bills you separately (checked 2026-09-03).
- −The best compounded rates require prepayment: $1,050 upfront for 6 months, $1,900 for 12. Start at $249 month-to-month if you want to test fit first.
- −The intake is a 90-second quiz. Fast, but lighter screening than competitors with full medical intakes. Better suited to patients who already know GLP-1 basics.
1 more documented cautions
- −TMates prescribes brand-name but does not dispense it, and is not affiliated with Novo Nordisk (Wegovy) or Eli Lilly (Zepbound). Your own pharmacy fills the Rx.
Our Verdict
Sesame Care edges out TMates with a score of 7.9/10 vs 7.8/10. Published pricing is not a like-for-like monthly comparison: Sesame Care is published $99/mo; total not verified; TMates is from $158/mo. TMates offers both brand-name and compounded medications, giving you more flexibility.
Keep narrowing the decision
What should you compare next?
Use the unresolved part of this choice, not a generic related article. These guides own the broader medication, coverage or complete-cost question.
- Pill decisionCompare Wegovy pill prices and accessUse the dedicated guide for dose-specific costs, required memberships and which providers currently list the FDA-approved pill.Continue
- Coverage decisionCheck your GLP-1 insurance pathLook up plan-specific coverage questions before treating a cash price or an insurance route as your final out-of-pocket cost.Continue
- Cost decisionCompare complete recurring program costsSee which prices include medication, clinical care and shipping, and which headline amounts require another fee or commitment.Continue
Reviews and pricing sources
Related comparisons
More head-to-head comparisons involving Sesame Care and TMates.
Not comparing, just asking? Quick answers to the most-asked GLP-1 questions →
- Compare Sesame Care and AgelessRxfrom $199/mo + $50/mo clinical oversight
- Compare Sesame Care and SynergyRxfrom $199/mo
- Compare Sesame Care and Breeze Medsfrom $199/mo
- Compare TMates and Wellorithmfrom $147/mo
- Compare TMates and MEDGmfrom $169/mo
- Compare TMates and Eden Health GLP-1$99/mo month-to-month
Not sure which one is right for you?
Answer a few quick questions and we'll match you to the best GLP-1 provider for your needs. Or keep exploring below.
Still working out whether either one is above board? We check that separately: is Sesame Care legit, with the verification evidence behind each answer.
Our pick of these two: Sesame Care · 7.9/10