SynergyRx vs Willow: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

48 providers verified independently·Independent research·How we rank →

Willow beats SynergyRx overall, scoring 8.2/10 vs 7.6/10. SynergyRx is more affordable at $199/mo vs $299/mo. Choose SynergyRx for users who want predictable bundled pricing with 24/7 support. Choose Willow for users who want comprehensive clinical support with flexibili.

A side-by-side comparison of SynergyRx and Willow covering pricing, scores, medication types, insurance, and more to help you decide.

SynergyRx

#24 of 48

7.6/10

Bundled GLP-1 program with predictable pricing and round-the-clock support access for peace of mind.

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Higher Rated

Willow

#8 of 48

8.2/10

Personalized GLP-1 weight loss with ongoing clinical support. Compounded semaglutide and tirzepatide only — Willow explicitly does not prescribe brand-name Wegovy or Zepbound. Added oral compounded semaglutide tablets as a non-injectable option.

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Feature	SynergyRx	Willow
Our Score	7.6/10	8.2/10
Starting Price	$199/mo	$299/mo
Medication Type	Both	Compounded
Insurance Accepted	No	No
Best For	Users who want predictable bundled pricing with 24/7 support access	Users who want comprehensive clinical support with flexibility between injectable and oral compounded semaglutide routes
Ranking	#24	#8

Pros & Cons Compared

SynergyRx

Pros

+Oral dissolving tablets for BOTH semaglutide AND tirzepatide — one of the few platforms with needle-free tirzepatide
+Free expedited shipping included with all orders
+24/7 support with unlimited messaging — no per-visit fees for follow-up questions or dose adjustments
+Both compounded and brand-name options available (Ozempic, Wegovy, Mounjaro)

Cons

−Casper, WY registration address and limited independent reviews raise legitimacy questions
−Brand-name pricing ($499-947/mo) is very high compared to direct manufacturer programs like LillyDirect
−Company history, founding date, and ownership structure are not publicly disclosed

Willow

Pros

+Includes monthly provider check-ins and dose adjustments at no extra cost
+Offers both injectable AND oral compounded semaglutide — one of few platforms with a daily oral tablet option
+$299/mo all-in for compounded semaglutide with monthly provider support
+90%+ patient retention rate after 3 months per their published outcomes data

Cons

−Compounded-only — no brand-name Wegovy or Zepbound through the platform
−Tirzepatide pricing reaches $499-$524 at higher doses — starting dose is $399/mo
−Cash-pay only — no insurance billing, though they provide superbills for FSA/HSA
−Founded in 2024 — less track record than Ro or Hims, though growth has been fast

Our Verdict

Willow edges out SynergyRx with a score of 8.2/10 vs 7.6/10. If budget is your priority, SynergyRx starts at $199/mo compared to Willow's $299/mo. SynergyRx offers both brand-name and compounded medications, giving you more flexibility. Choose SynergyRx if you want: users who want predictable bundled pricing with 24/7 support access. Choose Willow if you want: users who want comprehensive clinical support with flexibility between injectable and oral compounded semaglutide routes.

Still undecided? Editor's #1 Overall Pick

Eden Health GLP-1

$249/mo · 8.9/10 · Both

If neither SynergyRx nor Willow feels like the right fit, our overall #1 pick across all 48 GLP-1 telehealth providers is Eden Health GLP-1 — strongest balance of clinical oversight, transparent pricing, and verified availability.

Visit Eden Health GLP-1→Read our full Eden Health GLP-1 review