TMates vs TrimRx: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher

48 providers verified independently·Independent research·How we rank →

TrimRx beats TMates overall, scoring 8.3/10 vs 7.8/10. TMates is more affordable at $158/mo vs $199/mo. Choose TMates for users who want flexible pricing across compounded glp-1s (me. Choose TrimRx for users who want affordable compounded glp-1s with transparent.

A side-by-side comparison of TMates and TrimRx covering pricing, scores, medication types, insurance, and more to help you decide.

TMates

#16 of 48

7.8/10

Telemedicine platform offering two distinct archetypes: compounded semaglutide and tirzepatide with medication included (commitment pricing $158-$249/mo), and a clinical-service-only path to brand-name Wegovy/Zepbound at $99/mo where the prescription is sent to the patient's pharmacy. Phentermine also available. 2026 expansion added brand-name FDA-approved options.

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Higher Rated

TrimRx

#7 of 48

8.3/10

Budget-friendly compounded GLP-1 provider with straightforward pricing and a focus on accessibility.

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Feature	TMates	TrimRx
Our Score	7.8/10	8.3/10
Starting Price	$158/mo	$199/mo
Medication Type	Both	Both
Insurance Accepted	Yes	No
Best For	Users who want flexible pricing across compounded GLP-1s (medication included, $158-$249/mo with commitment discounts) and a cheap clinical-service-only path to brand Wegovy or Zepbound ($99/mo, patient fills at own pharmacy)	Users who want affordable compounded GLP-1s with transparent, all-inclusive pricing
Ranking	#16	#7

Pros & Cons Compared

TMates

Pros

+Steep multi-month commitment discounts on compounded sema — $158/mo on 12-month plan ($1,900 upfront) vs $249/mo month-to-month
+Clinical-service-only path to brand Wegovy and Zepbound at $99/mo — prescription goes to patient's pharmacy (you fill separately using insurance or cash)
+Same price at all dose levels for compounded — no cost escalation as you titrate up
+Phentermine available at $149/mo for patients who benefit from a different appetite-suppressant approach

Cons

−Brand Wegovy/Zepbound $99/mo is CLINICAL SERVICE ONLY — medication cost is separate (paid at your pharmacy, which can be $1,000+/mo cash without insurance)
−Best compounded pricing requires 6-12 month prepayment (upfront $1,050-$1,900)
−90-second assessment quiz suggests convenience over clinical thoroughness compared to competitors with full medical intakes
−Not affiliated with Novo Nordisk (Wegovy) or Eli Lilly (Zepbound) — TMates prescribes but does not dispense brand-name

TrimRx

Pros

+$179/mo all-inclusive for compounded semaglutide — one of the lowest prices for a full-service program
+Onboarding takes under 15 minutes with same-day provider review for most applications
+Published patient reviews averaging 4.5+ stars across third-party platforms
+Free medication replacement if your shipment is lost or damaged in transit

Cons

−Compounded semaglutide only — no brand-name options and no tirzepatide (compounded or otherwise)
−No insurance billing, and no superbill provided for out-of-network reimbursement

Our Verdict

TrimRx edges out TMates with a score of 8.3/10 vs 7.8/10. If budget is your priority, TMates starts at $158/mo compared to TrimRx's $199/mo. TMates accepts insurance, which can significantly reduce your out-of-pocket costs. Choose TMates if you want: users who want flexible pricing across compounded glp-1s (medication included, $158-$249/mo with commitment discounts) and a cheap clinical-service-only path to brand wegovy or zepbound ($99/mo, patient fills at own pharmacy). Choose TrimRx if you want: users who want affordable compounded glp-1s with transparent, all-inclusive pricing.

Still undecided? Editor's #1 Overall Pick

Eden Health GLP-1

$249/mo · 8.9/10 · Both

If neither TMates nor TrimRx feels like the right fit, our overall #1 pick across all 48 GLP-1 telehealth providers is Eden Health GLP-1 — strongest balance of clinical oversight, transparent pricing, and verified availability.

Visit Eden Health GLP-1→Read our full Eden Health GLP-1 review