Enhance MD vs SkinnyRx: Which GLP-1 Provider Is Better?
By Iacob Pastina, Independent Researcher
Enhance MD beats SkinnyRx overall, scoring 7.8/10 vs 7.3/10. SkinnyRx is more affordable at $199/mo vs $212/mo. Choose Enhance MD for budget-conscious users interested in combination therapies. Choose SkinnyRx for users who want flexibility in compounded glp-1 medication fo.
A side-by-side comparison of Enhance MD and SkinnyRx covering pricing, scores, medication types, insurance, and more to help you decide.
Enhance MD
#18 of 47Affordable telehealth provider offering both compounded and brand-name GLP-1 medications with combination therapy options.
Visit Enhance MDSkinnyRx
#36 of 47Direct-to-consumer telehealth platform offering compounded GLP-1 medications across five formats — injectable and sublingual semaglutide, semaglutide tablets, and tirzepatide as either injectable or tablets. Operated by Lean Rx, Inc. (Sacramento, CA). Compounded only — does not prescribe brand-name Wegovy/Zepbound/Ozempic/Mounjaro. Cash-pay only with HSA/FSA accepted; does not bill insurance. 4,100+ Trustpilot reviews at 4.8 stars.
Visit SkinnyRx| Feature | Enhance MD | SkinnyRx |
|---|---|---|
| Our Score | 7.8/10 | 7.3/10 |
| Starting Price | $212/mo | $199/mo |
| Medication Type | Both | Compounded |
| Insurance Accepted | No | No |
| Best For | Budget-conscious users interested in combination therapies | Users who want flexibility in compounded GLP-1 medication format (injectable, sublingual, or tablet) at a mid-tier price point |
| Ranking | #18 | #36 |
Pros & Cons Compared
Enhance MD
Pros
- +$115/mo starting price with access to both brand-name and compounded — rare at this price point
- +Offers combination therapies (GLP-1 + B12, GLP-1 + NAD+) for patients wanting enhanced protocols
- +Quick asynchronous consultations — most patients approved within 24 hours without video calls
- +Flexible dosing: can start at lower doses than standard protocols for sensitive patients
Cons
- −Lighter clinical support than higher-priced platforms — check-ins are patient-initiated, not scheduled
- −No insurance billing and limited customer support hours (business days only, no weekends)
SkinnyRx
Pros
- +Five medication formats — the broadest compounded-GLP-1 menu in DTC telehealth, including the rare oral tirzepatide tablet that almost no competitor offers
- +$199/mo entry price for both injectable and sublingual semaglutide is competitive in the mid-tier compounded segment
- +Fast onboarding: 5–10 minute online questionnaire, physician review in 24–48 hours, medication delivered in 3–7 business days with temperature-controlled shipping
- +4,100+ Trustpilot reviews at 4.8 stars — among the strongest aggregate social-proof signals in the GLP-1 telehealth category
Cons
- −No brand-name FDA-approved options (Wegovy, Zepbound, Ozempic, Mounjaro) — compounded-only model limits patients who want or need an FDA-approved finished product
- −Limited public transparency: founders, executive team, medical director, and specific compounding-pharmacy partners are not named on the public site
- −Cash-pay only — does not bill commercial insurance, Medicare, or Medicaid (HSA/FSA payments accepted)
- −Independent reviews flag inconsistent customer-service responsiveness, which is a real concern for a medication that requires titration support and dose-adjustment dialogue
Our Verdict
Enhance MD edges out SkinnyRx with a score of 7.8/10 vs 7.3/10. If budget is your priority, SkinnyRx starts at $199/mo compared to Enhance MD's $212/mo. Enhance MD offers both brand-name and compounded medications, giving you more flexibility. Choose Enhance MD if you want: budget-conscious users interested in combination therapies. Choose SkinnyRx if you want: users who want flexibility in compounded glp-1 medication format (injectable, sublingual, or tablet) at a mid-tier price point.