Enhance MD vs SkinnyRx: Which GLP-1 Provider Is Better?
Short answer: Enhance MD scores higher on our rubric, 7.8/10 against 5.3/10. Full reasoning, pricing and the cases where the other one wins are below.
Enhance MD beats SkinnyRx overall, scoring 7.8/10 vs 5.3/10. Published pricing is not a like-for-like monthly comparison: Enhance MD is from $212/mo; SkinnyRx is $99 first month, rises after. Choose Enhance MD for cash-pay shoppers who want the monthly price to stay flat as the dose goes up, and who will do a lab draw and a video visit to get it. Choose SkinnyRx for users who want a choice of compounded glp-1 format, a weekly injection or a daily tablet taken under the tongue, at a low first month price.
A side-by-side look at Enhance MD and SkinnyRx to help you decide. We compare them on:
- •Starting price and billing period
- •Our overall score, out of 10
- •Medication type, brand-name or compounded
- •Whether they accept insurance
- •Who each one is best for
Enhance MD
#8 of 36Cash-pay telehealth program selling compounded semaglutide, compounded tirzepatide, a formulation containing both, and a low-dose microdosing tirzepatide plan. Every GLP-1 it sells is compounded and not FDA-approved; there is no brand-name option. The price is flat at every dose, $212/mo on the 12-month plan and $249/mo month to month (verified 2026-09-03).
Visit Enhance MDSkinnyRx
#28 of 36Direct-to-consumer telehealth platform operated by Lean Rx, Inc. (Sacramento, CA). Its Treatments menu carries four compounded GLP-1 formats, semaglutide and tirzepatide each as a once-weekly injection or a once-daily tablet taken under the tongue, plus two brand-name oral pills, the Wegovy Pill and the Foundayo Pill, both badged FDA-approved and both shown as Unavailable and offered through a SkinnyRx Membership. Every advertised price is a first month rate. Compounded medications are not sold in Alabama, Louisiana or Mississippi. Cash-pay only with HSA/FSA accepted; does not bill insurance. 4,100+ Trustpilot reviews at 4.8 stars.
Visit SkinnyRx| Feature | Enhance MD | SkinnyRx |
|---|---|---|
| Why each one | The most affordable platform offering both medication types plus unique combination therapies (GLP-1 + B12, GLP-1 + NAD+) that no other major provider offers at this price. | Both GLP-1 molecules in both administration routes: semaglutide and tirzepatide, each as a once-weekly injection or a once-daily tablet taken under the tongue. The tirzepatide tablet in particular is a format almost no other DTC platform offers, and the two brand-name oral pills it lists alongside them are currently shown as Unavailable. |
| Our Score | 7.8/10 | 5.3/10 |
| Headline Price | from $212/mo | $99 first month, rises after |
| Medication Type | Compounded | Both |
| Insurance Accepted | No | No |
| Best For | Cash-pay shoppers who want the monthly price to stay flat as the dose goes up, and who will do a lab draw and a video visit to get it | Users who want a choice of compounded GLP-1 format, a weekly injection or a daily tablet taken under the tongue, at a low first month price |
| Watch out for | The $212/mo headline is the 12-month plan, billed every 48 weeks. Paying month to month costs $249/mo on the GLP-1 Core pricing page (verified 2026-09-03) | Every advertised price is a first month rate and SkinnyRx does not publish what month two costs. Its terms say the renewal rate is described at checkout, and that discounts may be reversed if you cancel before the end of a promotional or committed term. |
| Ranking | #8 | #28 |
| Get started | Visit Enhance MD | Visit SkinnyRx |
Pros & Cons Compared
Enhance MD
Pros
- +Same price at every dose, so titrating up does not raise the monthly bill. GLP-1 Core is $212/mo on the 12-month plan and $249/mo month to month (verified 2026-09-03)
- +The monthly price covers lab work, the video visit with a provider, medication from a partner pharmacy and 2-day shipping, with no separate consultation fee
- +Support is staffed seven days a week, Monday to Friday 8:00 AM to 8:00 PM EDT and Saturday to Sunday 9:00 AM to 5:00 PM EDT, by phone and email
- +Four compounded GLP-1 options including a capped 1mg microdosing tirzepatide plan at $169/mo, plus a full refund of the initial payment if a provider finds you ineligible during onboarding
Cons
- −The $212/mo headline is the 12-month plan, billed every 48 weeks. Paying month to month costs $249/mo on the GLP-1 Core pricing page (verified 2026-09-03)
- −Compounded only. Every GLP-1 product page states the formulation is not FDA-approved and is compounded under federal Section 503A guidelines, and no brand-name product is sold
- −Not nationwide. The FAQ lists 40 states plus DC and leaves out Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, North Dakota, South Carolina and Tennessee
- −Cash pay with no same-day start: a Quest Diagnostics blood draw and a scheduled video visit both come before a prescription, and no insurance option is shown on the site's pricing, FAQ or terms pages (rendered check 2026-09-03)
SkinnyRx
Pros
- +Four compounded formats, both molecules as both a weekly injection and a daily tablet taken under the tongue, including the tirzepatide tablet that almost no competitor offers
- +$99 for the first month on both the compounded semaglutide and the compounded tirzepatide injection, quoted on each product page, among the lowest entry rates in the compounded segment
- +Fast onboarding: a short online intake, a prescription within 24 hours where no video visit is required, and free overnight shipping on all orders with tracking within 2 business days
- +4,100+ Trustpilot reviews at 4.8 stars, among the strongest aggregate social-proof signals in the GLP-1 telehealth category
Cons
- −Every advertised price is a first month rate and SkinnyRx does not publish what month two costs. Its terms say the renewal rate is described at checkout, and that discounts may be reversed if you cancel before the end of a promotional or committed term.
- −SkinnyRx names its medical director, Sajad Zalzala, M.D., and names AyaRx as the telemedicine partner behind its medical services, but it does not name the compounding pharmacy that fills prescriptions and it publishes no founders or executive team.
- −Cash-pay only, does not bill commercial insurance, Medicare, or Medicaid. HSA/FSA payments are accepted, which is the main way to soften the cost.
- −Independent reviews flag inconsistent customer-service responsiveness, a real consideration since titration support and dose adjustments run through chat
- −FDA warning letter #717989, issued February 20, 2026 to Lean Rx, Inc. dba SkinnyRx, cites misleading labels and website claims for compounded GLP-1s. It is a labeling/marketing record, not an unsafe-medication finding
Our Verdict
Enhance MD edges out SkinnyRx with a score of 7.8/10 vs 5.3/10. Published pricing is not a like-for-like monthly comparison: Enhance MD is from $212/mo; SkinnyRx is $99 first month, rises after. SkinnyRx offers both brand-name and compounded medications, giving you more flexibility.
Reviews and pricing sources
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Our pick of these two: Enhance MD · 7.8/10