from $297/mo at Direct Meds GLP-1
Confirm the full bill · checked Sep 3
Check price for Direct Meds GLP-1On Direct Meds GLP-1's site · partner link
Comparison · updated October 16, 2026
Direct Meds GLP-1 vs SkinnyRx: Direct Meds GLP-1 for compounded medication only, SkinnyRx for brand-name or compounded options
Direct Meds GLP-1 and SkinnyRx differ in what you pay and which medicines they list. Compounded medicines are not FDA-approved.
First month, ask the renewal price · checked Sep 26
Check price for SkinnyRxOn SkinnyRx's site · partner link
These two prices are different kinds of bill, so read the line under each price before you compare them.
Direct Meds GLP-1 and SkinnyRx pay us a commission when you join through our links. That never changes a score, an order or a fact on this page. How we make money
Which should you choose, Direct Meds GLP-1 or SkinnyRx?
Short answer: Choose SkinnyRx if you want brand-name medicine as an option. If that doesn't matter to you, compare their plans below.
Direct Meds GLP-1 is best for
Users who value published format-specific pricing and can independently monitor billing and cancellation.
Choose SkinnyRx if
- you want brand-name medicine as an option
The available assessments do not establish a score winner, so choose by the medicine, total cost and care you need.
By Iacob Pastina, Independent Researcher & Publisher
Reviewed & updated · Cites primary sources (FDA, NEJM, CMS) · Not medical advice
Direct Meds GLP-1 vs SkinnyRx side by side
| Direct Meds GLP-1 | SkinnyRx | |
|---|---|---|
| Price | from $297/mo | $99First month, ask the renewal price |
| Medicine | Compounded only | Brand-name and compounded |
| Needle-free option | BothYes, a pill or other oral form | |
| Insurance | BothNo insurance listed | |
| Consultation | BothIncluded | |
| Shipping | Free | Free (overnight on all orders) |
| Where it ships | 48 states plus Washington DC, not Mississippi or Louisiana | 47 for compounded medications (its terms exclude Alabama, Louisiana and Mississippi and bar residents of those states from ordering them); branded offerings may be available in all states |
| Trustpilot | 4.6 / 5 across 16,278 reviews | 4.8 / 5 across 4,100 reviews |
| BBB rating | Not Rated (not accredited; October 9, 2026) | Not tracked |
| Our score | 7.5/10 Good | 5/10 Mixed |
| Assessment limits | Checked Oct 16, 2026. | Checked Oct 16, 2026; a rating claim didn't match Trustpilot. |
What Direct Meds GLP-1 and SkinnyRx plans cost
Direct Meds GLP-1
Separate injection and sublingual-drop options, with provider review, nursing support and shipping included. Online intake does not establish better or worse clinical care than another program.
- Compounded Semaglutide (injection)$297Injectable compounded semaglutide with provider review, nursing support and shipping included
- Compounded Semaglutide (sublingual drops)$249Sublingual drop format, advertised from $249 a month with shipping in the program bundle. Confirm the selected supply, full payment and refill terms.
- Compounded Tirzepatide (injection)$399Injectable compounded tirzepatide
All 4 Direct Meds GLP-1 plans
- Compounded Tirzepatide (sublingual drops)$299Sublingual drop format with a recorded rate of $299 a month. Confirm the current price, selected supply, full payment and refill terms.
We checked Direct Meds GLP-1's prices on September 3, 2026.
SkinnyRx
A four-product compounded menu with separate injection and dissolving-tablet pages for semaglutide and tirzepatide. Compare the exact formulation, introductory bill and renewal terms; the different routes are not established as clinically equivalent.
- Compounded Semaglutide (injectable)$99Once-weekly injection, quoted at $99 for the first month on its product page. A microdose option is offered.
- Compounded Semaglutide (tablets)$149Oral dissolving tablet, quoted at $149 for the first month. Confirm the exact dispensing directions and later bill; merchant guidance differs on placement.
- Compounded Tirzepatide (injectable)$99Once-weekly tirzepatide injection, a GLP-1 and GIP dual agonist, quoted at $99 for the first month on its product page.
All 4 SkinnyRx plans
- Compounded Tirzepatide (tablets)$199Oral dissolving tablet, quoted at $199 for the first month. Confirm the exact dispensing directions and later bill; this is not an FDA-approved oral tirzepatide product.
How SkinnyRx bills
$99 is a first month rate quoted on the compounded semaglutide and tirzepatide injection product pages. SkinnyRx does not publish a month two price; its terms say the renewal rate is described during checkout.
We checked SkinnyRx's prices on September 26, 2026.
What to watch for with Direct Meds GLP-1 and SkinnyRx
Direct Meds GLP-1
- Compounded medications only, no brand-name Wegovy, Zepbound, or Ozempic on the menu
- Injectable compounded semaglutide is $297 a month and the sublingual drops are $249 a month on the product page, so the cheaper in-house format saves $48, and both sit above the lowest cash-pay entry prices in this comparison
Direct Meds GLP-1's strengths, cautions and terms
Strengths
- The published $297/mo compounded semaglutide injection tier includes medication, consultations, shipping, and pharmacy fees
- Format-specific prices are published on the site, which makes the advertised medication and service bundle easier to compare
- Its executive team identifies Dr. Justin Hohl as chief medical officer
- Ongoing nursing access and digital follow-ups are described in the program bundle
More to watch for
- The marketing page says no subscriptions, but the terms cover automatic 30-day renewals for subscription products. Confirm which terms apply and the 48-hour cancellation cutoff
- Medicines listed
- Semaglutide (compounded injectable)
- Semaglutide (sublingual drops, $249/mo)
- Tirzepatide (compounded injectable)
- Tirzepatide (sublingual drops, $299/mo)
- NAD+ (non-GLP-1 wellness)
- Sermorelin (non-GLP-1 peptide)
- Insurance
- No insurance support listed
- Consultation
- Included
- Shipping
- Free
- States
- 48 states plus Washington DC, not Mississippi or Louisiana
- Cancellation
- For subscription products, turn off auto-refill at least 48 hours before the next processing date; terms specify 30-day billing with 5-7 days' advance notice. An order cancellation can be attempted within 24 hours only if the provider network has not received it. Received medication is non-refundable. Limited return exceptions apply, with a $35 disposal fee; report issues within 48 hours of receipt.
SkinnyRx
- Every advertised price is a first month rate and SkinnyRx does not publish what month two costs. Its terms say the renewal rate is described at checkout, and that discounts may be reversed if you cancel before the end of a promotional or committed term.
- SkinnyRx names its medical director, Sajad Zalzala, M.D., and names AyaRx as the telemedicine partner behind its medical services, but it does not name the compounding pharmacy that fills prescriptions and it publishes no founders or executive team.
SkinnyRx's strengths, cautions and terms
Strengths
- Four product-specific options to discuss with a clinician: semaglutide or tirzepatide, each as an injection or a dissolving tablet
- $99 for the first month on both the compounded semaglutide and the compounded tirzepatide injection, quoted on each product page, among the lowest entry rates in the compounded segment
- Fast onboarding: a short online intake, a prescription within 24 hours where no video visit is required, and free overnight shipping on all orders with tracking within 2 business days
- A public Trustpilot profile provides service feedback to read alongside the FDA record and the written billing terms; those reviews do not establish tablet effectiveness
More to watch for
- Cash-pay only, does not bill commercial insurance, Medicare, or Medicaid. HSA/FSA payments are accepted, which is the main way to soften the cost.
- Independent reviews flag inconsistent customer-service responsiveness, a real consideration since titration support and dose adjustments run through chat
- FDA warning letter #717989, issued February 20, 2026 to Lean Rx, Inc. dba SkinnyRx, cites misleading labels and website claims for compounded GLP-1s. It is a labeling/marketing record, not an unsafe-medication finding
- Medicines listed
- Semaglutide (compounded, injectable)
- Wegovy Pill (brand-name oral semaglutide, badged FDA-approved on its product page but shown as Unavailable and offered via SkinnyRx Membership, no price published, verified 2026-09-03)
- Foundayo Pill (brand-name orforglipron, badged FDA-approved on its product page but shown as Unavailable and offered via SkinnyRx Membership, no price published, verified 2026-09-03)
- Semaglutide (compounded, oral dissolving tablets; confirm placement with the dispensing pharmacy)
- Tirzepatide (compounded, injectable)
- Tirzepatide (compounded, oral dissolving tablets; confirm placement with the dispensing pharmacy)
- Insurance
- No insurance support listed
- Consultation
- Included
- Shipping
- Free (overnight on all orders)
- States
- 47 for compounded medications (its terms exclude Alabama, Louisiana and Mississippi and bar residents of those states from ordering them); branded offerings may be available in all states
- Cancellation
- The September 22 terms allow renewal processing up to five days before the next period and require cancellation at least five days before the applicable renewal-processing date. They include non-refundable fees, return-before-refund conditions and possible reversal of promotional discounts. Product FAQs use simpler cancellation/refund wording. Ask support for the exact deadline, refund eligibility and any return requirement in writing before paying; canceling is not a guaranteed refund.
Compounded medicines are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality before they are sold. Read the FDA's explanation of the risks.
Direct Meds GLP-1 vs SkinnyRx: common questions
Is Direct Meds GLP-1 or SkinnyRx cheaper?
At least one headline price is a starting, introductory, prepaid or partial figure, so neither is simply cheaper.
- Direct Meds GLP-1from $297/mostarting price
- SkinnyRx$99first month, ask the renewal price
Which is better, Direct Meds GLP-1 or SkinnyRx?
Neither wins outright on our scores, so the better one is the one that fits your medicine, budget and care needs.
Direct Meds GLP-1 lists compounded medication only, and SkinnyRx lists brand-name and compounded medication.
Do Direct Meds GLP-1 and SkinnyRx offer brand-name medication?
Direct Meds GLP-1 lists compounded medication only, and SkinnyRx lists brand-name and compounded medication.
Compounded medications are not FDA-approved. Your prescriber decides which medicine suits you.
Do Direct Meds GLP-1 and SkinnyRx take insurance?
Neither Direct Meds GLP-1 nor SkinnyRx lists insurance support.
Where these facts come from
Direct Meds GLP-1:prices checked September 3, 2026, score evidence assessed October 16, 2026.Read our Direct Meds GLP-1 review
SkinnyRx:prices checked September 26, 2026, score evidence assessed October 16, 2026.Read our SkinnyRx review
We score on a published methodology, and partnership never changes a score or a fact here.
What should you compare next?
- Compare Wegovy pill prices and accessUse the dedicated guide for dose-specific costs, required memberships and which providers currently list the FDA-approved pill.
- Compare complete recurring program costsSee which prices include medication, clinical care and shipping, and which headline amounts require another fee or commitment.
- Compare semaglutide providers and pricesMove from this head-to-head to the broader semaglutide market without confusing compounded products with FDA-approved brands.
Before you sign up, read our trust checks: is Direct Meds GLP-1 legit and is SkinnyRx legit.
Direct Meds GLP-1 reviewSkinnyRx reviewAll comparisonsFind your match