Sesame Care vs SkinnyRx: Which GLP-1 Provider Is Better?
Short answer: Sesame Care scores higher on our rubric, 7.9/10 against 5.3/10. Full reasoning, pricing and the cases where the other one wins are below.
Sesame Care beats SkinnyRx overall, scoring 7.9/10 vs 5.3/10. Published pricing is not a like-for-like monthly comparison: Sesame Care is published $99/mo; total not verified; SkinnyRx is $99 first month, rises after. Choose Sesame Care for users who want cheap fda-approved brand-name glp-1 access ($149-349/mo wegovy and zepbound via success by sesame), or insured patients who just need a prescriber. Choose SkinnyRx for users who want a choice of compounded glp-1 format, a weekly injection or a daily tablet taken under the tongue, at a low first month price.
A side-by-side look at Sesame Care and SkinnyRx to help you decide. We compare them on:
- •Starting price and billing period
- •Our overall score, out of 10
- •Medication type, brand-name or compounded
- •Whether they accept insurance
- •Who each one is best for
Sesame Care
#3 of 36Telehealth marketplace with two routes to a GLP-1 prescription: one-off video visits that start at $34 on the homepage, and the Success by Sesame subscription, which the weight loss program page prices at $59/mo on a 12-month commitment or $99 billed every 28 days with no commitment. It coordinates FDA-approved brand-name medication only, including Foundayo (orforglipron), the Wegovy pen and pill, and Zepbound. Medication is billed separately.
Visit Sesame CareSkinnyRx
#28 of 36Direct-to-consumer telehealth platform operated by Lean Rx, Inc. (Sacramento, CA). Its Treatments menu carries four compounded GLP-1 formats, semaglutide and tirzepatide each as a once-weekly injection or a once-daily tablet taken under the tongue, plus two brand-name oral pills, the Wegovy Pill and the Foundayo Pill, both badged FDA-approved and both shown as Unavailable and offered through a SkinnyRx Membership. Every advertised price is a first month rate. Compounded medications are not sold in Alabama, Louisiana or Mississippi. Cash-pay only with HSA/FSA accepted; does not bill insurance. 4,100+ Trustpilot reviews at 4.8 stars.
Visit SkinnyRx| Feature | Sesame Care | SkinnyRx |
|---|---|---|
| Why each one | The broadest FDA-approved brand-name GLP-1 menu among low-cost telehealth options, Wegovy pen and pill, Zepbound, Ozempic, Mounjaro, Rybelsus, and Foundayo, coordinated through the Success by Sesame membership at $59/mo on a 12-month commitment plus medication. | Both GLP-1 molecules in both administration routes: semaglutide and tirzepatide, each as a once-weekly injection or a once-daily tablet taken under the tongue. The tirzepatide tablet in particular is a format almost no other DTC platform offers, and the two brand-name oral pills it lists alongside them are currently shown as Unavailable. |
| Our Score | 7.9/10 | 5.3/10 |
| Headline Price | published $99/mo; total not verified | $99 first month, rises after |
| Medication Type | Brand | Both |
| Insurance Accepted | Yes | No |
| Best For | Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber | Users who want a choice of compounded GLP-1 format, a weekly injection or a daily tablet taken under the tongue, at a low first month price |
| Watch out for | Sesame runs three separate routes under one brand: the Success by Sesame weight loss subscription, EverydayRx for diabetes, and one-off visits from $34. Check which one you are signing up for before you pay. | Every advertised price is a first month rate and SkinnyRx does not publish what month two costs. Its terms say the renewal rate is described at checkout, and that discounts may be reversed if you cancel before the end of a promotional or committed term. |
| Ranking | #3 | #28 |
| Get started | Visit Sesame Care | Visit SkinnyRx |
Pros & Cons Compared
Sesame Care
Pros
- +Success by Sesame is $59/mo on the 12-month commitment and includes provider visits, unlimited messaging and provider choice; lab work is covered only at Quest Diagnostics and not in AZ, HI, ND, NJ, NY, OK, RI, SD or WY, where lab fees are extra; medication is separate
- +Brand-name cash pricing is competitive, Wegovy pen $199 intro / $349 ongoing, Zepbound vial $299, Wegovy pill $149
- +Foundayo (Lilly's FDA-approved oral GLP-1) available as of April 2026 at $149/mo
- +The pay-per-visit route is still there, with visits starting at $34, for users who just need a prescriber
Cons
- −Sesame runs three separate routes under one brand: the Success by Sesame weight loss subscription, EverydayRx for diabetes, and one-off visits from $34. Check which one you are signing up for before you pay.
- −The $59/mo Success by Sesame rate applies only on a 12-month commitment. The 3-month plan works out near $79/mo and the 6-month near $69/mo from the savings the FAQ publishes, and the no-commitment plan is $99 billed every 28 days, which is 13 charges a year.
- −There is no compounded option. Sesame states that compounded semaglutide is not currently available through it, so every route here is brand-name and the medication is billed on top of the program fee.
- −A marketplace rather than a concierge, expect less hand-holding than dedicated subscription platforms
SkinnyRx
Pros
- +Four compounded formats, both molecules as both a weekly injection and a daily tablet taken under the tongue, including the tirzepatide tablet that almost no competitor offers
- +$99 for the first month on both the compounded semaglutide and the compounded tirzepatide injection, quoted on each product page, among the lowest entry rates in the compounded segment
- +Fast onboarding: a short online intake, a prescription within 24 hours where no video visit is required, and free overnight shipping on all orders with tracking within 2 business days
- +4,100+ Trustpilot reviews at 4.8 stars, among the strongest aggregate social-proof signals in the GLP-1 telehealth category
Cons
- −Every advertised price is a first month rate and SkinnyRx does not publish what month two costs. Its terms say the renewal rate is described at checkout, and that discounts may be reversed if you cancel before the end of a promotional or committed term.
- −SkinnyRx names its medical director, Sajad Zalzala, M.D., and names AyaRx as the telemedicine partner behind its medical services, but it does not name the compounding pharmacy that fills prescriptions and it publishes no founders or executive team.
- −Cash-pay only, does not bill commercial insurance, Medicare, or Medicaid. HSA/FSA payments are accepted, which is the main way to soften the cost.
- −Independent reviews flag inconsistent customer-service responsiveness, a real consideration since titration support and dose adjustments run through chat
- −FDA warning letter #717989, issued February 20, 2026 to Lean Rx, Inc. dba SkinnyRx, cites misleading labels and website claims for compounded GLP-1s. It is a labeling/marketing record, not an unsafe-medication finding
Our Verdict
Sesame Care edges out SkinnyRx with a score of 7.9/10 vs 5.3/10. Published pricing is not a like-for-like monthly comparison: Sesame Care is published $99/mo; total not verified; SkinnyRx is $99 first month, rises after. Sesame Care accepts insurance, which can significantly reduce your out-of-pocket costs. SkinnyRx offers both brand-name and compounded medications, giving you more flexibility.
Reviews and pricing sources
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Our pick of these two: Sesame Care · 7.9/10