Sesame Care vs SkinnyRx: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher & Publisher

Reviewed & updated August 14, 2026 · Cites primary sources (FDA, NEJM, CMS) · Not medical advice

54 providers verified independently·Independent research·How we rank →

Visit Sesame Care - our pick of these two →or find your match

Sesame Care beats SkinnyRx overall, scoring 7.9/10 vs 5.3/10. Published pricing is not a like-for-like monthly comparison: Sesame Care is published $99/mo; total not verified; SkinnyRx is from $199/mo. Choose Sesame Care for users who want cheap fda-approved brand-name glp-1 access ($. Choose SkinnyRx for users who want flexibility in compounded glp-1 medication fo.

A side-by-side look at Sesame Care and SkinnyRx to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Higher Rated

Sesame Care

#5 of 54

7.9/10

Telehealth marketplace offering both a low-cost consultation model ($25/visit) and the new Success by Sesame membership program ($59/mo on 3/6/12-month plans), which coordinates access to FDA-approved brand-name GLP-1 medications including Foundayo (orforglipron), Wegovy pen and pill, and Zepbound. Medication is billed separately.

Visit Sesame Care

SkinnyRx

#48 of 54

5.3/10

Direct-to-consumer telehealth platform offering compounded GLP-1 medications across five formats, injectable and sublingual semaglutide, semaglutide tablets, and tirzepatide as either injectable or tablets. Operated by Lean Rx, Inc. (Sacramento, CA). Compounded only, does not prescribe brand-name Wegovy/Zepbound/Ozempic/Mounjaro. Cash-pay only with HSA/FSA accepted; does not bill insurance. 4,100+ Trustpilot reviews at 4.8 stars.

Visit SkinnyRx

Feature	Sesame Care	SkinnyRx
Why each one	The broadest FDA-approved brand-name GLP-1 menu among low-cost telehealth options, Wegovy pen and pill, Zepbound, Ozempic, Mounjaro, Rybelsus, and Foundayo, coordinated through the new Success by Sesame membership at $59/mo plus medication.	The broadest compounded-GLP-1 menu in DTC telehealth, five medication formats including the uncommon sublingual semaglutide and even rarer oral tirzepatide tablets. Most competitors offer one or two formats; SkinnyRx covers every administration route a compounded patient might prefer.
Our Score	7.9/10	5.3/10
Headline Price	published $99/mo; total not verified	from $199/mo
Medication Type	Both	Compounded
Insurance Accepted	Yes	No
Best For	Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber	Users who want flexibility in compounded GLP-1 medication format (injectable, sublingual, or tablet) at a mid-tier price point
Watch out for	Two distinct products (pay-per-visit vs the Success membership) sit side by side, so decide which you're buying before checkout	No brand-name FDA-approved options (Wegovy, Zepbound, Ozempic, Mounjaro), so patients who want or need an FDA-approved finished product should buy elsewhere
Ranking	#5	#48
Get started	Visit Sesame Care	Visit SkinnyRx

Pros & Cons Compared

Sesame Care

Pros

+Success by Sesame program launched 2026, $59/mo on a 3/6/12-month plan, includes labs, unlimited messaging, and provider choice; medication is separate
+Brand-name cash pricing is competitive, Wegovy pen $199 intro / $349 ongoing, Zepbound vial $299, Wegovy pill $149
+Foundayo (Lilly's FDA-approved oral GLP-1) available as of April 2026 at $149/mo
+Original pay-per-visit model still available at $25/consultation for users who just need a prescriber

Cons

−Two distinct products (pay-per-visit vs the Success membership) sit side by side, so decide which you're buying before checkout
−The $59/mo Success by Sesame rate requires a 3-month minimum commitment; month-to-month is available at $99/mo if you don't want to commit
−Compounded meds are de-emphasized in the current marketing, the platform now leads with FDA-approved brand-name paths
−A marketplace rather than a concierge, expect less hand-holding than dedicated subscription platforms

SkinnyRx

Pros

+Five medication formats, the broadest compounded-GLP-1 menu in DTC telehealth, including the rare oral tirzepatide tablet that almost no competitor offers
+$199/mo entry price for both injectable and sublingual semaglutide is competitive in the mid-tier compounded segment
+Fast onboarding: 5-10 minute online questionnaire, physician review in 24-48 hours, medication delivered in 3-7 business days with temperature-controlled shipping
+4,100+ Trustpilot reviews at 4.8 stars, among the strongest aggregate social-proof signals in the GLP-1 telehealth category

Cons

−No brand-name FDA-approved options (Wegovy, Zepbound, Ozempic, Mounjaro), so patients who want or need an FDA-approved finished product should buy elsewhere
−Light public disclosure: founders, executive team, medical director, and specific compounding-pharmacy partners are not named on the public site, ask support before enrolling if provenance matters to you
−Cash-pay only, does not bill commercial insurance, Medicare, or Medicaid. HSA/FSA payments are accepted, which is the main way to soften the cost.
−Independent reviews flag inconsistent customer-service responsiveness, a real consideration since titration support and dose adjustments run through chat
−FDA warning letter #717989, issued February 20, 2026 to Lean Rx, Inc. dba SkinnyRx, cites misleading labels and website claims for compounded GLP-1s. It is a labeling/marketing record, not an unsafe-medication finding

Our Verdict

Sesame Care edges out SkinnyRx with a score of 7.9/10 vs 5.3/10. Published pricing is not a like-for-like monthly comparison: Sesame Care is published $99/mo; total not verified; SkinnyRx is from $199/mo. Sesame Care accepts insurance, which can significantly reduce your out-of-pocket costs. Sesame Care offers both brand-name and compounded medications, giving you more flexibility. Choose Sesame Care if you want: users who want cheap fda-approved brand-name glp-1 access ($149-349/mo wegovy and zepbound via success by sesame), or insured patients who just need a prescriber. Choose SkinnyRx if you want: users who want flexibility in compounded glp-1 medication format (injectable, sublingual, or tablet) at a mid-tier price point.