Enhance MD vs Sesame Care: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher & Publisher

Reviewed & updated August 14, 2026 · Cites primary sources (FDA, NEJM, CMS) · Not medical advice

54 providers verified independently·Independent research·How we rank →

Short answer: Sesame Care scores higher on our rubric, 7.9/10 against 7.8/10. Full reasoning, pricing and the cases where the other one wins are below.

Visit Sesame Care - our pick of these two →or find your match

Sesame Care beats Enhance MD overall, scoring 7.9/10 vs 7.8/10. Published pricing is not a like-for-like monthly comparison: Enhance MD is from $212/mo; Sesame Care is published $99/mo; total not verified. Choose Enhance MD for budget-conscious users interested in combination therapies. Choose Sesame Care for users who want cheap fda-approved brand-name glp-1 access ($149-349/mo wegovy and zepbound via success by sesame), or insured patients who just need a prescriber.

A side-by-side look at Enhance MD and Sesame Care to help you decide. We compare them on:

•Starting price per month
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Enhance MD

#13 of 54

7.8/10

Affordable telehealth provider offering both compounded and brand-name GLP-1 medications with combination therapy options.

Visit Enhance MD

Higher Rated

Sesame Care

#5 of 54

7.9/10

Telehealth marketplace offering both a low-cost consultation model ($25/visit) and the new Success by Sesame membership program ($59/mo on 3/6/12-month plans), which coordinates access to FDA-approved brand-name GLP-1 medications including Foundayo (orforglipron), Wegovy pen and pill, and Zepbound. Medication is billed separately.

Visit Sesame Care

Feature	Enhance MD	Sesame Care
Why each one	The most affordable platform offering both medication types plus unique combination therapies (GLP-1 + B12, GLP-1 + NAD+) that no other major provider offers at this price.	The broadest FDA-approved brand-name GLP-1 menu among low-cost telehealth options, Wegovy pen and pill, Zepbound, Ozempic, Mounjaro, Rybelsus, and Foundayo, coordinated through the new Success by Sesame membership at $59/mo plus medication.
Our Score	7.8/10	7.9/10
Headline Price	from $212/mo	published $99/mo; total not verified
Medication Type	Both	Both
Insurance Accepted	No	Yes
Best For	Budget-conscious users interested in combination therapies	Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber
Watch out for	Check-ins are patient-initiated rather than scheduled; portal requests are usually answered within 24 hours, but you drive the cadence	Two distinct products (pay-per-visit vs the Success membership) sit side by side, so decide which you're buying before checkout
Ranking	#13	#5
Get started	Visit Enhance MD	Visit Sesame Care

Pros & Cons Compared

Enhance MD

Pros

+GLP-1 from $49 your first month, then $212/mo, with access to both brand-name and compounded; wafers as low as $84/mo on the 6-month plan
+Offers combination therapies (GLP-1 + B12, GLP-1 + NAD+) for patients wanting enhanced protocols
+Quick asynchronous consultations, most patients approved within 24 hours without video calls
+Flexible dosing: can start at lower doses than standard protocols for sensitive patients

Cons

−Check-ins are patient-initiated rather than scheduled; portal requests are usually answered within 24 hours, but you drive the cadence
−No insurance billing, and customer support runs business days only, no weekends

Sesame Care

Pros

+Success by Sesame program launched 2026, $59/mo on a 3/6/12-month plan, includes labs, unlimited messaging, and provider choice; medication is separate
+Brand-name cash pricing is competitive, Wegovy pen $199 intro / $349 ongoing, Zepbound vial $299, Wegovy pill $149
+Foundayo (Lilly's FDA-approved oral GLP-1) available as of April 2026 at $149/mo
+Original pay-per-visit model still available at $25/consultation for users who just need a prescriber

Cons

−Two distinct products (pay-per-visit vs the Success membership) sit side by side, so decide which you're buying before checkout
−The $59/mo Success by Sesame rate requires a 3-month minimum commitment; month-to-month is available at $99/mo if you don't want to commit
−Compounded meds are de-emphasized in the current marketing, the platform now leads with FDA-approved brand-name paths
−A marketplace rather than a concierge, expect less hand-holding than dedicated subscription platforms

Our Verdict

Sesame Care edges out Enhance MD with a score of 7.9/10 vs 7.8/10. Published pricing is not a like-for-like monthly comparison: Enhance MD is from $212/mo; Sesame Care is published $99/mo; total not verified. Sesame Care accepts insurance, which can significantly reduce your out-of-pocket costs.