Independent provider comparison
Updated September 21, 2026
Enhance MD vs Sesame Care: Which GLP-1 provider is better?
A side-by-side look at total cost, medication format, care, commitment and the situations where each option makes more sense.
The decision
Which should you choose, Enhance MD or Sesame Care?
Short answer: Sesame Care scores higher on our published rubric, 7.9/10 against 7.8/10. Published pricing is not a like-for-like monthly comparison: Enhance MD is from $212/mo; Sesame Care is published $99/mo; total not verified.
Consider Enhance MD if
Cash-pay shoppers who want the monthly price to stay flat as the dose goes up, and who will do a lab draw and a video visit to get it.
Consider Sesame Care if
Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber.
Scores follow our published methodology. Partnership status does not change the score or the factual comparison.
Cost
First charge, renewal and commitment
Treatment
Medication, form and approval status
Care
Clinical review and ongoing support
Terms
Cancellation and material cautions
Enhance MD
#8 of 36Best for cash-pay shoppers who want the monthly price to stay flat as the dose goes up, and who will do a lab draw and a video visit to get it.
Visit Enhance MD
Sesame Care
#3 of 36Best for users who want cheap fda-approved brand-name glp-1 access ($149-349/mo wegovy and zepbound via success by sesame), or insured patients who just need a prescriber.
Visit Sesame CareSide by side
Enhance MD vs Sesame Care at a glance
Compare the price unit as well as the number. A medication-only price, prepaid monthly equivalent and complete recurring program are not the same thing.
| Feature | Enhance MD | Sesame Care |
|---|---|---|
| Why each one | The most affordable platform offering both medication types plus unique combination therapies (GLP-1 + B12, GLP-1 + NAD+) that no other major provider offers at this price. | The broadest FDA-approved brand-name GLP-1 menu among low-cost telehealth options, Wegovy pen and pill, Zepbound, Ozempic, Mounjaro, Rybelsus, and Foundayo, coordinated through the Success by Sesame membership at $59/mo on a 12-month commitment plus medication. |
| Our Score | 7.8/10 | 7.9/10 |
| Headline Price | from $212/mo | published $99/mo; total not verified |
| Medication Type | Compounded | Brand |
| Insurance Accepted | No | Yes |
| Best For | Cash-pay shoppers who want the monthly price to stay flat as the dose goes up, and who will do a lab draw and a video visit to get it | Users who want cheap FDA-approved brand-name GLP-1 access ($149-349/mo Wegovy and Zepbound via Success by Sesame), or insured patients who just need a prescriber |
| Watch out for | The $212/mo headline is the 12-month plan, billed every 48 weeks. Paying month to month costs $249/mo on the GLP-1 Core pricing page (verified 2026-09-03) | Sesame runs three separate routes under one brand: the Success by Sesame weight loss subscription, EverydayRx for diabetes, and one-off visits from $34. Check which one you are signing up for before you pay. |
| Ranking | #8 | #3 |
| Get started | Visit Enhance MD | Visit Sesame Care |
Trade-offs
Strengths and cautions compared
Enhance MD
Pros
- +Same price at every dose, so titrating up does not raise the monthly bill. GLP-1 Core is $212/mo on the 12-month plan and $249/mo month to month (verified 2026-09-03)
- +The monthly price covers lab work, the video visit with a provider, medication from a partner pharmacy and 2-day shipping, with no separate consultation fee
- +Support is staffed seven days a week, Monday to Friday 8:00 AM to 8:00 PM EDT and Saturday to Sunday 9:00 AM to 5:00 PM EDT, by phone and email
1 more documented strengths
- +Four compounded GLP-1 options including a capped 1mg microdosing tirzepatide plan at $169/mo, plus a full refund of the initial payment if a provider finds you ineligible during onboarding
Cons
- −The $212/mo headline is the 12-month plan, billed every 48 weeks. Paying month to month costs $249/mo on the GLP-1 Core pricing page (verified 2026-09-03)
- −Compounded only. Every GLP-1 product page states the formulation is not FDA-approved and is compounded under federal Section 503A guidelines, and no brand-name product is sold
- −Not nationwide. The FAQ lists 40 states plus DC and leaves out Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, North Dakota, South Carolina and Tennessee
1 more documented cautions
- −Cash pay with no same-day start: a Quest Diagnostics blood draw and a scheduled video visit both come before a prescription, and no insurance option is shown on the site's pricing, FAQ or terms pages (rendered check 2026-09-03)
Sesame Care
Pros
- +Success by Sesame is $59/mo on the 12-month commitment and includes provider visits, unlimited messaging and provider choice; lab work is covered only at Quest Diagnostics and not in AZ, HI, ND, NJ, NY, OK, RI, SD or WY, where lab fees are extra; medication is separate
- +Brand-name cash pricing is competitive, Wegovy pen $199 intro / $349 ongoing, Zepbound vial $299, Wegovy pill $149
- +Foundayo (Lilly's FDA-approved oral GLP-1) available as of April 2026 at $149/mo
1 more documented strengths
- +The pay-per-visit route is still there, with visits starting at $34, for users who just need a prescriber
Cons
- −Sesame runs three separate routes under one brand: the Success by Sesame weight loss subscription, EverydayRx for diabetes, and one-off visits from $34. Check which one you are signing up for before you pay.
- −The $59/mo Success by Sesame rate applies only on a 12-month commitment. The 3-month plan works out near $79/mo and the 6-month near $69/mo from the savings the FAQ publishes, and the no-commitment plan is $99 billed every 28 days, which is 13 charges a year.
- −There is no compounded option. Sesame states that compounded semaglutide is not currently available through it, so every route here is brand-name and the medication is billed on top of the program fee.
1 more documented cautions
- −A marketplace rather than a concierge, expect less hand-holding than dedicated subscription platforms
Our Verdict
Sesame Care edges out Enhance MD with a score of 7.9/10 vs 7.8/10. Published pricing is not a like-for-like monthly comparison: Enhance MD is from $212/mo; Sesame Care is published $99/mo; total not verified. Sesame Care accepts insurance, which can significantly reduce your out-of-pocket costs.
Keep narrowing the decision
What should you compare next?
Use the unresolved part of this choice, not a generic related article. These guides own the broader medication, coverage or complete-cost question.
- Pill decisionCompare Wegovy pill prices and accessUse the dedicated guide for dose-specific costs, required memberships and which providers currently list the FDA-approved pill.Continue
- Coverage decisionCheck your GLP-1 insurance pathLook up plan-specific coverage questions before treating a cash price or an insurance route as your final out-of-pocket cost.Continue
- Cost decisionCompare complete recurring program costsSee which prices include medication, clinical care and shipping, and which headline amounts require another fee or commitment.Continue
Reviews and pricing sources
Related comparisons
More head-to-head comparisons involving Enhance MD and Sesame Care.
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- Compare Sesame Care and MEDVi$179 first month, then $299/mo
- Compare Sesame Care and bmiMDfrom $159/mo
- Compare Sesame Care and Direct Meds GLP-1from $297/mo
Not sure which one is right for you?
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Still working out whether either one is above board? We check that separately: is Enhance MD legit and is Sesame Care legit, with the verification evidence behind each answer.
Our pick of these two: Sesame Care · 7.9/10