MangoRx vs SkinnyRx: Which GLP-1 Provider Is Better?

By Iacob Pastina, Independent Researcher & Publisher

Reviewed & updated September 15, 2026 · Cites primary sources (FDA, NEJM, CMS) · Not medical advice

36 providers verified independently·Independent research·How we rank →

Short answer: MangoRx scores higher on our rubric, 7.5/10 against 5.3/10. Full reasoning, pricing and the cases where the other one wins are below.

Visit MangoRx - our pick of these two →or find your match

MangoRx beats SkinnyRx overall, scoring 7.5/10 vs 5.3/10. Published pricing is not a like-for-like monthly comparison: MangoRx is from $299/mo; SkinnyRx is $99 first month, rises after. Choose MangoRx for needle-phobic users who want oral-only glp-1 tablets from a publicly traded company. Choose SkinnyRx for users who want a choice of compounded glp-1 format, a weekly injection or a daily tablet taken under the tongue, at a low first month price.

A side-by-side look at MangoRx and SkinnyRx to help you decide. We compare them on:

•Starting price and billing period
•Our overall score, out of 10
•Medication type, brand-name or compounded
•Whether they accept insurance
•Who each one is best for

Higher Rated

MangoRx

#12 of 36

7.5/10

Men's telehealth platform built around erectile function, testosterone and hair treatments, with one compounded GLP-1 tablet, Slim, as its entire weight loss line.

Visit MangoRx

SkinnyRx

#28 of 36

5.3/10

Direct-to-consumer telehealth platform operated by Lean Rx, Inc. (Sacramento, CA). Its Treatments menu carries four compounded GLP-1 formats, semaglutide and tirzepatide each as a once-weekly injection or a once-daily tablet taken under the tongue, plus two brand-name oral pills, the Wegovy Pill and the Foundayo Pill, both badged FDA-approved and both shown as Unavailable and offered through a SkinnyRx Membership. Every advertised price is a first month rate. Compounded medications are not sold in Alabama, Louisiana or Mississippi. Cash-pay only with HSA/FSA accepted; does not bill insurance. 4,100+ Trustpilot reviews at 4.8 stars.

Visit SkinnyRx

Feature	MangoRx	SkinnyRx
Why each one	Oral dissolving tablets exclusively (zero injections) from a publicly traded company (NASDAQ: MGRX) with SEC-level financial transparency.	Both GLP-1 molecules in both administration routes: semaglutide and tirzepatide, each as a once-weekly injection or a once-daily tablet taken under the tongue. The tirzepatide tablet in particular is a format almost no other DTC platform offers, and the two brand-name oral pills it lists alongside them are currently shown as Unavailable.
Our Score	7.5/10	5.3/10
Headline Price	from $299/mo	$99 first month, rises after
Medication Type	Compounded	Both
Insurance Accepted	No	No
Best For	Needle-phobic users who want oral-only GLP-1 tablets from a publicly traded company	Users who want a choice of compounded GLP-1 format, a weekly injection or a daily tablet taken under the tongue, at a low first month price
Watch out for	Oral semaglutide at $299/mo runs 2-3x injectable alternatives ($99-149/mo). The premium only makes sense if needles are a hard no for you.	Every advertised price is a first month rate and SkinnyRx does not publish what month two costs. Its terms say the renewal rate is described at checkout, and that discounts may be reversed if you cancel before the end of a promotional or committed term.
Ranking	#12	#28
Get started	Visit MangoRx	Visit SkinnyRx

Pros & Cons Compared

MangoRx

Pros

+Oral dissolving tablets exclusively, zero injections for any GLP-1 option
+Publicly traded on NASDAQ (MGRX), SEC-required financial transparency that private competitors can't match
+Semaglutide tablet includes Vitamin B6 to help reduce nausea during treatment
+Intake is 100% online with no insurance needed, and the provider visit costs nothing when it ends in a prescription

Cons

−Oral semaglutide at $299/mo runs 2-3x injectable alternatives ($99-149/mo). The premium only makes sense if needles are a hard no for you.
−Early-stage public company with limited revenue; the same SEC filings that provide transparency also show the financial uncertainty reflected in the stock.
−Oral tablets are the only format, with no injectable option if you want higher bioavailability. If you may switch to injections later, pick a platform that carries both.

SkinnyRx

Pros

+Four compounded formats, both molecules as both a weekly injection and a daily tablet taken under the tongue, including the tirzepatide tablet that almost no competitor offers
+$99 for the first month on both the compounded semaglutide and the compounded tirzepatide injection, quoted on each product page, among the lowest entry rates in the compounded segment
+Fast onboarding: a short online intake, a prescription within 24 hours where no video visit is required, and free overnight shipping on all orders with tracking within 2 business days
+4,100+ Trustpilot reviews at 4.8 stars, among the strongest aggregate social-proof signals in the GLP-1 telehealth category

Cons

−Every advertised price is a first month rate and SkinnyRx does not publish what month two costs. Its terms say the renewal rate is described at checkout, and that discounts may be reversed if you cancel before the end of a promotional or committed term.
−SkinnyRx names its medical director, Sajad Zalzala, M.D., and names AyaRx as the telemedicine partner behind its medical services, but it does not name the compounding pharmacy that fills prescriptions and it publishes no founders or executive team.
−Cash-pay only, does not bill commercial insurance, Medicare, or Medicaid. HSA/FSA payments are accepted, which is the main way to soften the cost.
−Independent reviews flag inconsistent customer-service responsiveness, a real consideration since titration support and dose adjustments run through chat
−FDA warning letter #717989, issued February 20, 2026 to Lean Rx, Inc. dba SkinnyRx, cites misleading labels and website claims for compounded GLP-1s. It is a labeling/marketing record, not an unsafe-medication finding

Our Verdict

MangoRx edges out SkinnyRx with a score of 7.5/10 vs 5.3/10. Published pricing is not a like-for-like monthly comparison: MangoRx is from $299/mo; SkinnyRx is $99 first month, rises after. SkinnyRx offers both brand-name and compounded medications, giving you more flexibility.