Compounded semaglutide · billed monthly · checked Oct 28
Check price for PlexusDxOn PlexusDx's site · partner link
Comparison · updated October 28, 2026
Compare PlexusDx and TrimRx by the exact medication, form and payment term first.
Compounded semaglutide · billed monthly · checked Oct 28
Check price for PlexusDxOn PlexusDx's site · partner link
12-month plan · confirm the full bill · checked Oct 28
Check price for TrimRxOn TrimRx's site · partner link
These two prices are different kinds of bill, so read the line under each price before you compare them.
PlexusDx and TrimRx pay us a commission through our referral links. We checked the direct public offers and written terms on October 28, 2026. We did not buy treatment or use either service as patients. Separate customer-review evidence retains its own dates. How we make money
TrimRX does not practice medicine or prescribe medications. Compounded medications are not FDA-approved and are not evaluated by the FDA for safety or efficacy. Results vary by individual and are not guaranteed. See https://trimrx.com/safety-information for additional information.
PlexusDx lists monthly semaglutide at $149 and tirzepatide at $189, plus lower monthly equivalents with stated prepaid totals. TrimRx's selected price-lock offer lists GLP-1 at $174 month to month and GLP-1 + GIP at $279; its longer-plan monthly equivalents do not establish the amount due upfront. PlexusDx makes the full prepaid commitment clearer. TrimRx's current terms describe a separate 28-day refund-request route for unused prepaid treatment attributable to future unfilled orders. Neither a posted price nor this policy comparison establishes which treatment is medically right for you.
Four medication/form choices with stated prepaid bills
PlexusDx publishes injection and oral-tablet options for both semaglutide and tirzepatide, with actual payment totals for each term.
Longer plans are prepaid. Confirm clinical eligibility and the cancellation stage before committing the full amount.
A written refund-request route for unused prepaid treatment
TrimRx's terms allow a separate refund request for the unused prepaid portion attributable to future unfilled orders within 28 days of the applicable payment.
Cancellation alone does not create a refund. A prescription already sent to the pharmacy continues to fulfillment; confirm the selected plan's full bill.
Sources: PlexusDx semaglutide plans · PlexusDx tirzepatide plans · TrimRx selected price-lock offer · TrimRx current cancellation and refund terms
| PlexusDx | TrimRx | |
|---|---|---|
| Price | $149/moMonth-to-month, from $99 on a plan | from $149/mo12-month plan rate; confirm full payment and renewal |
| Medicine | BothCompounded medication (selected plans) | |
| Needle-free option | Yes, a pill or other oral form | Not confirmed in the checked offer |
| Insurance | Self-pay; PlexusDx does not bill health insurance | No insurance listed |
| Consultation | Included: independent provider assessment and clinically required phone or video consultation | Included |
| Shipping | Included | Free |
| Where it ships | Not confirmed | TrimRx does not publish a served-state count or a state list |
| Trustpilot | Not tracked | 3.8 / 5 across 5,410 reviews |
| BBB rating | Not tracked | F (not accredited) |
| Our score | 8.3/10 Very good | 4.7/10 Limited |
| Assessment limits | Checked Oct 28, 2026; some details not published. | Checked Oct 16, 2026; a rating claim didn't match Trustpilot. |
The same published term ladder applies to both forms of each medicine, with dose-stable pricing within that medicine and plan.
Semaglutide is $149 month-to-month. Its $99 monthly equivalent requires $1,188 paid upfront for 12 months. Tirzepatide is $189 monthly or $129 per month equivalent with $1,548 annual prepayment. Three- and six-month plans are also prepaid. Dose changes do not increase the price within the same medicine and plan; switching medicines changes the applicable price. Optional add-ons, outside testing and applicable taxes are additional.
We checked PlexusDx's prices on October 28, 2026.
Four compounded products through one intake, injectable and oral, plus a shipping policy that grants a refund if nothing ships within 14 days. Neither resolves the price conflict between its offer page and its terms, nor the fulfillment complaint record.
Advertised monthly rate on the 12-month GLP-1 price-lock plan; month-to-month is $174. Confirm the full payment and price-lock conditions. Generic package terms still list $199 first order then $299 follow-up for GLP-1, and $349 then $399 for GLP-1 + GIP; ask which written schedule applies. Total under review
We checked TrimRx's prices on October 28, 2026.
PlexusDx semaglutide injection and oral dissolving tablets each cost $149 month to month. Its three-, six- and twelve-month terms are $129, $109 and $99 per month equivalent, with $387, $654 and $1,188 paid upfront. Tirzepatide injection and oral tablets each cost $189 monthly, or $169, $149 and $129 per month equivalent with $507, $894 and $1,548 upfront. Prepaid plans renew for the selected term under the terms. Optional add-ons, outside testing and applicable taxes can add cost.
TrimRx's selected GLP-1 ladder is $174 monthly, then $166, $158 and $149 per month on the three-, six- and twelve-month plans. Its GLP-1 + GIP ladder is $279 monthly, then $266, $258 and $249 per month for those terms. The month-to-month option is explicit; the longer plans' charging frequency and full amount due upfront were not independently confirmed. Get that written bill before choosing a term.
TrimRx's general package terms separately list GLP-1 at $199 initially and $299 for follow-up, and GLP-1 + GIP at $349 initially and $399 for follow-up. Those are a different schedule, not an automatic renewal prediction for the selected price-lock offer. Confirm which written schedule applies; do not treat a price-lock headline as an unconditional lifetime guarantee.
The separate PlexusDx microdose protocol does not set the price of standard semaglutide or tirzepatide treatment. Compare a like-for-like prescription and term; the available figures do not establish TrimRx's annual upfront bill or a guaranteed annual saving.
Sources:PlexusDx standard semaglutide term prices· PlexusDx standard tirzepatide term prices· PlexusDx prepaid renewal and inclusions· TrimRx current selected-plan ladder· TrimRx general package schedule· PlexusDx complete pricing guide· TrimRx pricing and offer conditions
PlexusDx explicitly lists four choices: compounded semaglutide injection, semaglutide oral dissolving tablets, tirzepatide injection and tirzepatide oral dissolving tablets. Its same-molecule link opens both forms, so select the intended form and term on the medicine page. Product illustrations identify the merchant's option and may differ from the dispensed packaging.
The checked TrimRx offer labels its plans GLP-1 and GLP-1 + GIP. That category label alone does not establish an oral product at the quoted price. Confirm the prescribed ingredient, formulation, dose and dispensing pharmacy before treating either quote as a match. Separate branded-medication services in the terms are outside these compounded-plan prices.
Compounded medicines are not FDA-approved finished products. PlexusDx's oral dissolving tablets are not FDA-approved Wegovy or Rybelsus tablets, and a shared molecule name does not establish interchangeable absorption, dosing or outcomes. A formulation preference is a question for the prescriber, not a reason to assume equivalent treatment.
Sources:PlexusDx semaglutide injection product· PlexusDx semaglutide oral product· PlexusDx tirzepatide injection product· PlexusDx tirzepatide oral product· TrimRx selected medication categories· TrimRx compounded and branded-service distinction· FDA: risks of compounded drugs· Approved pills and compounded oral formulations
At PlexusDx, withdrawal before clinical approval costs $0. After approval but before pharmacy transmission, a timely cancellation can receive a full refund. After transmission, a change of mind does not create a refund right for that prescription. Stop the next renewal in the patient portal before the charge is processed; email or support requests need at least three business days.
Canceling a prepaid PlexusDx plan stops the next term rather than automatically refunding the current one. Its terms provide exceptions for unused, not-yet-dispensed prepaid months after medical discontinuation or qualifying legal or operational nonfulfillment. Confirm the applicable stage and keep written confirmation of any request.
TrimRx allows cancellation through the account or support. Before pharmacy transmission, the order is canceled and any applicable refund follows its policy. After transmission, that order continues to fulfillment and cancellation affects future unfilled orders. For a prepaid multi-month plan, separately request a refund within 28 days of the applicable payment for the unused portion attributable to future unfilled orders. After that window, the terms generally exclude that unused-portion refund, subject to the stated exceptions and applicable law. A cancellation is not itself a refund request.
Sources:PlexusDx cancellation, renewal and refund terms· TrimRx current refund eligibility and request requirements
Both platforms require an independent clinician to decide whether a prescription is appropriate. PlexusDx names Lone Star Virtual Health as its independent clinical group and identifies Vials RX as a pharmacy partner; your assigned clinician and pharmacy depend on the assessment and prescription. TrimRx describes independent affiliated physician groups and participating pharmacies. Neither platform's marketing is an individual clinical approval.
PlexusDx serves adults 18 and older subject to clinical and state availability, and its terms exclude Medicaid enrollees even when self-paying. TrimRx's selected offer says eligible U.S. states; the reviewed material does not establish a Medicaid rule to carry over from PlexusDx or an individual state's availability. Confirm your own eligibility with each provider before paying or switching.
Both selected offers are self-pay. Insurance is not required at TrimRx, while PlexusDx says it does not bill health insurance. Payment-card or HSA/FSA acceptance does not settle your reimbursement eligibility. If your goal is an insured branded prescription, compare that access route separately from these compounded offers.
Sources:PlexusDx independent care and eligibility terms· PlexusDx named clinical group and pharmacy partner· TrimRx eligible-state and self-pay offer FAQs· TrimRx independent clinical and pharmacy services
Choose PlexusDx when its four stated medication/form choices and complete prepaid totals answer your main shopping questions, and you accept the commitment for that term. Consider TrimRx when its selected monthly offer or its written unused-prepaid refund-request route fits your priorities, after confirming the actual payment schedule and prescription. The refund policy is a decision condition, not a guarantee that every prepaid month can be recovered.
Ask both for the prescribed product and form, amount due now, next payment date and amount, clinician contact route, dispensing pharmacy and cancellation status. If you are already being treated, ask your clinician how to manage a transition; a previous prescription does not guarantee the same dose, acceptance or delivery date.
Sources:PlexusDx care, formulation and eligibility review· PlexusDx complete payment ladder· TrimRx review and current offer context· TrimRx pricing and written terms· PlexusDx current terms· TrimRx current terms
Strengths
More to watch for
Strengths
More to watch for
Compounded medicines are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality before they are sold. Read the FDA's explanation of the risks.
PlexusDx lists monthly semaglutide at $149 and tirzepatide at $189.
The prescription stage matters at both.
No. The separate microdose protocol does not set standard semaglutide or tirzepatide prices.
No. PlexusDx's compounded oral dissolving tablets are different finished products from FDA-approved branded tablets.
PlexusDx's terms exclude Medicaid enrollees even when self-paying.
PlexusDx:prices checked October 28, 2026, score evidence assessed October 28, 2026.Read our PlexusDx review
TrimRx:prices checked October 28, 2026, score evidence assessed October 16, 2026.Read our TrimRx review
We score on a published methodology, and partnership never changes a score or a fact here.
Both PlexusDx and TrimRx start above the cheapest complete recurring program we track. Across all 40 providers in our index, the lowest price that includes the medicine, consultation and shipping is Eden Health GLP-1 at $99/mo, checked August 28, 2026. This is a price fact, not a treatment recommendation. Compare every program by its complete price
Before you sign up, read our trust check: is TrimRx legit.