$212/4 weeks equivalent at Enhance MD
48-week prepay · checked Aug 28
Check price for Enhance MDOn Enhance MD's site · partner link
Comparison · updated October 16, 2026
Enhance MD vs TMates: Enhance MD for compounded medication only, TMates for brand-name or compounded options
Enhance MD and TMates differ in what you pay, which medicines they list and their insurance terms. Compounded medicines are not FDA-approved.
Compounded semaglutide · 12-month plan · $1,900 up front · checked Sep 3
Check price for TMatesOn TMates' site · partner link
These two prices are different kinds of bill, so read the line under each price before you compare them.
Enhance MD and TMates pay us a commission when you join through our links. That never changes a score, an order or a fact on this page. How we make money
Which should you choose, Enhance MD or TMates?
Short answer: Choose TMates if you want brand-name medicine as an option. If that doesn't matter to you, compare their plans below.
Enhance MD is best for
Cash-pay shoppers who want the monthly price to stay flat as the dose goes up, and who will do a lab draw and a video visit to get it.
Choose TMates if
- you want brand-name medicine as an option
- you want a pill or another option without needles
- you want to use insurance
The available assessments do not establish a score winner, so choose by the medicine, total cost and care you need.
By Iacob Pastina, Independent Researcher & Publisher
Reviewed & updated · Cites primary sources (FDA, NEJM, CMS) · Not medical advice
Enhance MD vs TMates side by side
| Enhance MD | TMates | |
|---|---|---|
| Price | $212/4 weeks equivalentPrepaid 48-week plan; confirm the full upfront charge | from $158/mo |
| Medicine | Compounded only | Brand-name and compounded |
| Needle-free option | Not listed | Yes, a pill or other oral form |
| Insurance | No insurance listed | Accepts insurance |
| Consultation | BothIncluded | |
| Shipping | Free | Free (for compounded; brand-name filled at patient's pharmacy) |
| Where it ships | 40 states plus DC: AK, AZ, CA, CO, CT, DC, DE, FL, IA, ID, IL, IN, KS, KY, MA, MD, ME, MI, MN, MT, NC, NE, NH, NJ, NM, NV, NY, OH, OK, OR, PA, RI, SD, TX, UT, VA, VT, WA, WI, WV, WY | Most states |
| Trustpilot | 4.0 / 5 across 162 reviews | Not tracked |
| BBB rating | A+ (not accredited) | B (not accredited) |
| Our score | 9.4/10 Excellent | 6/10 Fair |
| Assessment limits | Checked Oct 16, 2026; some details not published. | Checked Oct 16, 2026; few independent reviews yet. |
What Enhance MD and TMates plans cost
Enhance MD
A compounded GLP-1 program with published lab work and a scheduled video visit before prescribing. Core and Advanced are separate molecule options; Elite combines semaglutide and tirzepatide in one formulation. Four-week billing and prepaid 12-, 24- and 48-week plans are not calendar-month or calendar-year prices.
- Microdose Tirzepatide$169/4 weeks1 mg a week of compounded tirzepatide, capped rather than increased. $169 per four-week equivalent on the 12-month plan billed every 48 weeks, $179 on the 6-month plan billed every 24 weeks and $189 on the 3-month plan billed every 12 weeks. Medication ships every 12 weeks. The page showed no price for the 1-month option.
- Compounded Semaglutide (12-month plan)$212/4 weeksAdvertised four-week equivalent; prepaid every 48 weeks, not a calendar year
- Compounded Semaglutide (6-month plan)$224/4 weeksAdvertised four-week equivalent; prepaid every 24 weeks, not calendar months
All 11 Enhance MD plans
- Compounded Semaglutide (3-month plan)$237/4 weeksAdvertised four-week equivalent; prepaid every 12 weeks, not calendar months
- Compounded Semaglutide (month-to-month)$249/4 weeksBilled every 4 weeks
- Compounded Tirzepatide (12-month)$280/4 weeks$280 advertised four-week-equivalent rate on the 12-month plan, billed every 48 weeks; confirm the full upfront total before paying.
- Compounded Tirzepatide (6-month)$296/4 weeks$296 advertised four-week-equivalent rate on the 6-month plan, billed every 24 weeks; confirm the full upfront total before paying.
- Compounded Tirzepatide (3-month)$313/4 weeks$313 advertised four-week-equivalent rate on the 3-month plan, billed every 12 weeks; confirm the full upfront total before paying.
- Compounded Tirzepatide (month-to-month)$329/4 weeks$329 billed every 4 weeks on the shortest plan, before any eligible first-order discount.
- Elite Bundle (sema + tirz)$322A compounded formulation containing semaglutide and tirzepatide together; historical $189 introductory price requires confirmation of the current plan and charge
- NAD+ Therapy (subcutaneous)$169NAD+ injection therapy, separate product line, not a GLP-1
How Enhance MD bills
$212 advertised four-week equivalent on the prepaid 48-week plan, not a calendar-year subscription; shortest plan is $249 billed every 4 weeks
We checked Enhance MD's prices on August 28, 2026.
TMates
Two-archetype platform: (1) compounded GLP-1s with medication included and steep multi-month commitment discounts; (2) cheap $99/mo clinical service for brand Wegovy/Zepbound where you fill the prescription at your own pharmacy.
- Compounded Semaglutide (month-to-month)$249$249/mo month-to-month with medication and free shipping included, all doses at same price
- Compounded Semaglutide (3-month plan)$217$217/mo on 3-month commitment ($650 upfront, save 13%)
- Compounded Semaglutide (6-month plan)$175$175/mo on 6-month commitment ($1,050 upfront, save 30%)
All 11 TMates plans
- Compounded Semaglutide (12-month plan)$158$158/mo on 12-month commitment ($1,900 upfront, save 37%), lowest effective rate
- Compounded Tirzepatide (month-to-month)$297$297/mo month-to-month with medication and free shipping included, all doses at same price
- Compounded Tirzepatide (3-month plan)$267$267/mo on 3-month commitment ($800 upfront, save 10%)
- Compounded Tirzepatide (6-month plan)$217$217/mo on 6-month commitment ($1,299 upfront, save 27%)
- Compounded Tirzepatide (12-month plan)$167$167/mo on 12-month commitment ($1,999 upfront, save 44%), lowest effective rate
- Phentermine (oral)$149$149/mo, non-GLP-1 appetite suppressant. The page is badged Clinical Service Only and says the price includes clinical evaluation and prescription management, while the body copy says a licensed pharmacy fills the prescription and ships it to your home, so confirm whether the medication is included before you pay (checked 2026-09-03)
- Wegovy (brand clinical service only)$99$99/mo for the prescription + provider oversight. Medication cost is separate, you fill the Rx at your own pharmacy.
- Zepbound (brand clinical service only)$99$99/mo for the prescription + provider oversight. Medication cost is separate, you fill the Rx at your own pharmacy.
We checked TMates' prices on September 3, 2026.
What to watch for with Enhance MD and TMates
Enhance MD
- The $212 headline is a four-week equivalent on a prepaid 48-week plan, not a calendar-year price. The shortest plan costs $249 every four weeks on the GLP-1 Core pricing page (verified 2026-09-03)
- Compounded only. Every GLP-1 product page states the formulation is not FDA-approved and is compounded under federal Section 503A guidelines, and no brand-name product is sold
Enhance MD's strengths, cautions and terms
Strengths
- Same price at every dose, so titrating up does not raise the monthly bill. GLP-1 Core is $212 per four-week equivalent on the prepaid 48-week plan and $249 every four weeks on the shortest plan (verified 2026-09-03)
- The monthly price covers lab work, the video visit with a provider, medication from a partner pharmacy and 2-day shipping, with no separate consultation fee
- Support is staffed seven days a week, Monday to Friday 8:00 AM to 8:00 PM EDT and Saturday to Sunday 9:00 AM to 5:00 PM EDT, by phone and email
- Four compounded GLP-1 options including a capped 1 mg microdosing tirzepatide plan from $169 per four weeks on the 48-week plan, plus a full refund of the initial payment if a provider finds you ineligible during onboarding
More to watch for
- Not nationwide. The FAQ lists 40 states plus DC and leaves out Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, North Dakota, South Carolina and Tennessee
- Cash pay with no same-day start: a Quest Diagnostics blood draw and a scheduled video visit both come before a prescription, and no insurance option is shown on the site's pricing, FAQ or terms pages (rendered check 2026-09-03)
- Medicines listed
- Semaglutide (compounded, sold as GLP-1 Core)
- Tirzepatide (compounded, sold as GLP-1 Advanced)
- Semaglutide and tirzepatide in one formulation (compounded, sold as GLP-1 Elite)
- Tirzepatide, 1mg microdosing plan (compounded)
- NAD+ injections (separate anti-aging product, not a GLP-1)
- NAD+ wafers (separate anti-aging product, not a GLP-1)
- Insurance
- No insurance support listed
- Consultation
- Included
- Shipping
- Free
- States
- 40 states plus DC: AK, AZ, CA, CO, CT, DC, DE, FL, IA, ID, IL, IN, KS, KY, MA, MD, ME, MI, MN, MT, NC, NE, NH, NJ, NM, NV, NY, OH, OK, OR, PA, RI, SD, TX, UT, VA, VT, WA, WI, WV, WY. Not available in AL, AR, GA, HI, LA, MO, MS, ND, SC, TN. The FAQ says the company is licensed in all 50 states but that it is launching in the listed states only (verified 2026-09-03)
- Cancellation
- The FAQ says you can pause or cancel your subscription at any time by contacting support, and that membership otherwise renews every 28 days. The 3, 6 and 12-month plans bill every 12, 24 and 48 weeks rather than monthly. Prescription products cannot be returned, and the only refund promised is 100% of the initial payment if a provider finds you ineligible during onboarding (verified 2026-09-03)
TMates
- The $99/mo Wegovy or Zepbound tier buys the prescription and provider oversight only. TMates says it does not dispense or ship the drug, and no price for the medication itself appears on its product or category pages, so your own pharmacy bills you separately (checked 2026-09-03).
- The best compounded rates require prepayment: $1,050 upfront for 6 months, $1,900 for 12. Start at $249 month-to-month if you want to test fit first.
TMates' strengths, cautions and terms
Strengths
- Clinical-service-only path to brand Wegovy and Zepbound at $99/mo, prescription goes to patient's pharmacy (you fill separately using insurance or cash)
- Steep multi-month commitment discounts on compounded sema, $158/mo on 12-month plan ($1,900 upfront) vs $249/mo month-to-month
- Same price at all dose levels for compounded, no cost escalation as you titrate up
- Phentermine available at $149/mo for patients who benefit from a different appetite-suppressant approach
More to watch for
- TMates prescribes brand-name but does not dispense it, and is not affiliated with Novo Nordisk (Wegovy) or Eli Lilly (Zepbound). Your own pharmacy fills the Rx.
- Medicines listed
- Semaglutide (compounded, injectable or oral)
- Tirzepatide (compounded injectable; the product page also shows an Oral format, but every dosing instruction on it describes a weekly injection)
- Phentermine (oral)
- Wegovy (brand-name clinical service only, prescription, not dispensing)
- Zepbound (brand-name clinical service only, prescription, not dispensing)
- Insurance
- Lists insurance support. Confirm coverage for your plan.
- Consultation
- Included
- Shipping
- Free (for compounded; brand-name filled at patient's pharmacy)
- States
- Most states. TMates advertises all 50 states on its homepage and 50+ states on its about page, while its semaglutide page says it ships to most states based on medical eligibility (checked 2026-09-03)
- Cancellation
- Product pages say cancel anytime. The terms give a full refund only before the medical review, or after it if you do not qualify. Once a prescription is written and sent to a pharmacy there is no refund, and a denied refund request leaves any payment plan in force (checked 2026-09-03)
Compounded medicines are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality before they are sold. Read the FDA's explanation of the risks.
Enhance MD vs TMates: common questions
Is Enhance MD or TMates cheaper?
At least one headline price is a starting, introductory, prepaid or partial figure, so neither is simply cheaper.
- Enhance MD$212/4 weeks equivalentprepaid 48-week plan; confirm the full upfront charge
- TMatesfrom $158/mostarting price
Which is better, Enhance MD or TMates?
Neither wins outright on our scores, so the better one is the one that fits your medicine, budget and care needs.
Enhance MD lists compounded medication only, and TMates lists brand-name and compounded medication. TMates lists insurance support, and Enhance MD does not.
Do Enhance MD and TMates offer brand-name medication?
Enhance MD lists compounded medication only, and TMates lists brand-name and compounded medication.
Compounded medications are not FDA-approved. Your prescriber decides which medicine suits you.
Do Enhance MD and TMates take insurance?
TMates lists insurance support, and Enhance MD does not.
Confirm coverage for your exact plan and prescription before you pay.
Where these facts come from
Enhance MD:prices checked August 28, 2026, score evidence assessed October 16, 2026.Read our Enhance MD review
TMates:prices checked September 3, 2026, score evidence assessed October 16, 2026.Read our TMates review
We score on a published methodology, and partnership never changes a score or a fact here.
What should you compare next?
- Compare Wegovy pill prices and accessUse the dedicated guide for dose-specific costs, required memberships and which providers currently list the FDA-approved pill.
- Check your GLP-1 insurance pathLook up plan-specific coverage questions before treating a cash price or an insurance route as your final out-of-pocket cost.
- Compare complete recurring program costsSee which prices include medication, clinical care and shipping, and which headline amounts require another fee or commitment.
Both Enhance MD and TMates start above the cheapest complete recurring program we track. Across all 38 providers in our index, the lowest price that includes the medicine, consultation and shipping is Eden Health GLP-1 at $99/mo, checked August 28, 2026. This is a price fact, not a treatment recommendation. Compare every program by its complete price
Before you sign up, read our trust check: is Enhance MD legit.
Enhance MD reviewTMates reviewAll comparisonsFind your match