Enhance MD vs TMates: Which GLP-1 Provider Is Better?
Short answer: Enhance MD and TMates tie at 7.8/10 on our rubric, so the decision comes down to price and format rather than overall quality. Full reasoning, pricing and the cases where the other one wins are below.
Enhance MD and TMates are tied at 7.8/10. Published pricing is not a like-for-like monthly comparison: Enhance MD is from $212/mo; TMates is from $158/mo. Choose Enhance MD for budget-conscious users interested in combination therapies. Choose TMates for users who want commitment-discount pricing on compounded glp-1s ($158-$249/mo, medication included) or a $99/mo clinical path to brand wegovy or zepbound filled at their own pharmacy.
A side-by-side look at Enhance MD and TMates to help you decide. We compare them on:
- •Starting price per month
- •Our overall score, out of 10
- •Medication type, brand-name or compounded
- •Whether they accept insurance
- •Who each one is best for
Enhance MD
#13 of 54Affordable telehealth provider offering both compounded and brand-name GLP-1 medications with combination therapy options.
Visit Enhance MDTMates
#11 of 54Telemedicine platform offering two distinct archetypes: compounded semaglutide and tirzepatide with medication included (commitment pricing $158-$249/mo), and a clinical-service-only path to brand-name Wegovy/Zepbound at $99/mo where the prescription is sent to the patient's pharmacy. Phentermine also available. 2026 expansion added brand-name FDA-approved options.
Visit TMates| Feature | Enhance MD | TMates |
|---|---|---|
| Why each one | The most affordable platform offering both medication types plus unique combination therapies (GLP-1 + B12, GLP-1 + NAD+) that no other major provider offers at this price. | Two-archetype platform: (1) compounded GLP-1s with medication included and steep multi-month commitment discounts; (2) cheap $99/mo clinical service for brand Wegovy/Zepbound where you fill the prescription at your own pharmacy. |
| Our Score | 7.8/10 | 7.8/10 |
| Headline Price | from $212/mo | from $158/mo |
| Medication Type | Both | Both |
| Insurance Accepted | No | Yes |
| Best For | Budget-conscious users interested in combination therapies | Users who want commitment-discount pricing on compounded GLP-1s ($158-$249/mo, medication included) or a $99/mo clinical path to brand Wegovy or Zepbound filled at their own pharmacy |
| Watch out for | Check-ins are patient-initiated rather than scheduled; portal requests are usually answered within 24 hours, but you drive the cadence | The $99/mo Wegovy/Zepbound tier is the clinical service only. Medication is billed separately at your pharmacy (can be $1,000+/mo cash without insurance). Choose this tier when your insurance covers the drug itself. |
| Ranking | #13 | #11 |
| Get started | Visit Enhance MD | Visit TMates |
Pros & Cons Compared
Enhance MD
Pros
- +GLP-1 from $49 your first month, then $212/mo, with access to both brand-name and compounded; wafers as low as $84/mo on the 6-month plan
- +Offers combination therapies (GLP-1 + B12, GLP-1 + NAD+) for patients wanting enhanced protocols
- +Quick asynchronous consultations, most patients approved within 24 hours without video calls
- +Flexible dosing: can start at lower doses than standard protocols for sensitive patients
Cons
- −Check-ins are patient-initiated rather than scheduled; portal requests are usually answered within 24 hours, but you drive the cadence
- −No insurance billing, and customer support runs business days only, no weekends
TMates
Pros
- +Clinical-service-only path to brand Wegovy and Zepbound at $99/mo, prescription goes to patient's pharmacy (you fill separately using insurance or cash)
- +Steep multi-month commitment discounts on compounded sema, $158/mo on 12-month plan ($1,900 upfront) vs $249/mo month-to-month
- +Same price at all dose levels for compounded, no cost escalation as you titrate up
- +Phentermine available at $149/mo for patients who benefit from a different appetite-suppressant approach
Cons
- −The $99/mo Wegovy/Zepbound tier is the clinical service only. Medication is billed separately at your pharmacy (can be $1,000+/mo cash without insurance). Choose this tier when your insurance covers the drug itself.
- −The best compounded rates require prepayment: $1,050 upfront for 6 months, $1,900 for 12. Start at $249 month-to-month if you want to test fit first.
- −The intake is a 90-second quiz. Fast, but lighter screening than competitors with full medical intakes. Better suited to patients who already know GLP-1 basics.
- −TMates prescribes brand-name but does not dispense it, and is not affiliated with Novo Nordisk (Wegovy) or Eli Lilly (Zepbound). Your own pharmacy fills the Rx.
Our Verdict
Enhance MD and TMates are closely matched with identical scores of 7.8/10. Published pricing is not a like-for-like monthly comparison: Enhance MD is from $212/mo; TMates is from $158/mo. TMates accepts insurance, which can significantly reduce your out-of-pocket costs.
Read Full Reviews
Related comparisons
More head-to-head comparisons involving Enhance MD and TMates.
- Enhance MD vs Zealthyfrom $286/mo
- Enhance MD vs Lemonaid Healthpublished $129/mo; total not verified
- Enhance MD vs MEDVi$179 first month, then $299/mo
- TMates vs Eden Health GLP-1from $249/mo
- TMates vs Zealthyfrom $286/mo
- TMates vs Noom Med$79 first month, then $199/mo
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